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List of works by Michael Duffy

A High Parasite Density Environment Induces Transcriptional Changes and Cell Death in Plasmodium falciparum Blood Stages

scientific article published on 27 December 2017

A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression

scientific article

A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies

scientific article published on 19 May 2016

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria

scientific article published on 28 December 2005

Activation and clustering of a Plasmodium falciparum var gene are affected by subtelomeric sequences

scientific article

Antigenic Variation in Plasmodium falciparum

scientific article published on January 2015

Broad analysis reveals a consistent pattern of var gene transcription in Plasmodium falciparum repeatedly selected for a defined adhesion phenotype

scientific article published in May 2005

Characterization of VAR2CSA-deficient Plasmodium falciparum-infected erythrocytes selected for adhesion to the BeWo placental cell line

scientific article published on 26 March 2008

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

scientific article published on 11 July 2019

Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa

scientific article

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

scientific article published on 01 November 2019

Developments in drug design strategies for bromodomain protein inhibitors to target Plasmodium falciparum parasites

scientific article published on 23 December 2019

Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

scientific article

Ectopic recombination of a malaria var gene during mitosis associated with an altered var switch rate.

scientific article published on 21 April 2009

Epigenetic regulation of the Plasmodium falciparum genome

scientific article published on 10 December 2013

Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women

scientific article

Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation

scientific article published on 30 August 2006

Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter

scientific article

H2A.Z and H2B.Z double-variant nucleosomes define intergenic regions and dynamically occupy var gene promoters in the malaria parasite Plasmodium falciparum

scientific article published on 4 February 2013

Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum

scientific article published in April 2005

Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences

scientific article published on 23 November 2020

Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections

scientific article

Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion.

scientific article published on May 2001

Patterns of protective associations differ for antibodies to P.falciparum-infected erythrocytes and merozoites in immunity against malaria in children.

scientific article

PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division

scientific article (publication date: 19 January 2012)

Plasmodium falciparum malaria elicits inflammatory responses that dysregulate placental amino acid transport

scientific article

Polyacrylamide Gel-Electrophoresis Separation of Whole-Cell Proteins ⬇️

scientific article published on 01 January 1998

Population genomics of virulence genes of Plasmodium falciparum in clinical isolates from Uganda

scientific article published on 18 September 2017

Regulation of antigenic variation in Plasmodium falciparum: censoring freedom of expression?

scientific article published on March 2003

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum

scientific article (publication date: 14 April 2009)

Structural basis for binding of Plasmodium falciparum erythrocyte membrane protein 1 to chondroitin sulfate and placental tissue and the influence of protein polymorphisms on binding specificity

scientific article published on 11 June 2007

Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity

scientific article

Targets of protective antibodies to malaria during pregnancy

scientific article

Temporal expression and localization patterns of variant surface antigens in clinical Plasmodium falciparum isolates during erythrocyte schizogony

scientific article

The Plasmodium falciparum transcriptome in severe malaria reveals altered expression of genes involved in important processes including surface antigen-encoding var genes

scientific article published on 12 March 2018

The role of bromodomain proteins in regulating gene expression

scientific article published on 29 May 2012

The role of chromatin in Plasmodium gene expression

scientific article published on 28 March 2012

Transcribed var genes associated with placental malaria in Malawian women.

scientific article

Transcription and coregulation of multigene families in Plasmodium falciparum

scientific article published on 9 March 2007

Transcription of multiple var genes by individual, trophozoite-stage Plasmodium falciparum cells expressing a chondroitin sulphate A binding phenotype

scientific article published in March 2002

VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum

scientific article published on 7 April 2006

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