List of works - Eddy Sotelo

1,5-dimethyl-6H-pyridazino[4,5-b]carbazole, a 3-aza bioisoster of the antitumor alkaloid olivacine

scientific article published in November 2002

1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor

scientific article

2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies

scientific article published on 17 November 2007

3,4-Dihydropyrimidin-2(1<i>H</i>)-ones as Antagonists of the Human A<sub>2B</sub> Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition

scientific article published on 29 December 2020

5-amino-6-phenyl-1,6-dihydropyridazin-3(2H)-one

scientific article

8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B.

scientific article

A novel quantitative multiplex real-time RT-PCR for the simultaneous detection and differentiation of West Nile virus lineages 1 and 2, and of Usutu virus ⬇️

scientific article published on March 7, 2013

Click chemistry approach to assembly proline mimetic libraries containing 1,4-substituted 1,2,3-triazoles

scientific article published on 30 April 2008

Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke

scientific article published on 22 August 2018

Computer-aided design of GPCR ligands

scientific article published on January 2015

Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases

scientific article published on 30 December 2017

Convergent assembly of structurally diverse quinazolines

scientific article published on 03 November 2010

Copper-catalyzed Huisgen 1,3-dipolar cycloaddition under oxidative conditions: polymer-assisted assembly of 4-acyl-1-substituted-1,2,3-triazoles

scientific article published on 14 June 2013

Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Abeta1-40 aggregation in vitro

scientific article published on 25 March 2008

Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor

scientific article

Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity

scientific article

Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors

scientific article published on 7 September 2017

Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane- 4,6-diones as platelet aggregation inhibitors

scientific article published on 01 August 2012

Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists

scientific article

Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes

scientific article published on 09 February 2016

Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists

scientific article

Drug structural features affect drug delivery from hyperbranched polyesteramide hot melt extrudates

scientific article published on 18 February 2016

Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists

scientific article published on 9 August 2017

Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

scientific article published on 3 April 2017

Expanding the chemical diversity of azinone libraries by a consecutive alkylation/palladium-catalyzed functionalization strategy

scientific article published on 01 July 2005

Free-Energy Calculations for Bioisosteric Modifications of A3 Adenosine Receptor Antagonists

scientific article published on 16 July 2019

Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones

scientific article published on 20 January 2015

Multicomponent Assembly of the Kinesin Spindle Protein Inhibitor CPUYJ039 and Analogues as Antimitotic Agents.

scientific article

Multicomponent assembly of diverse pyrazin-2(1H)-one chemotypes

scientific article

Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells

scientific article published on 14 August 2006

Personality traits in patients with cluster headache: a comparison with migraine patients.

scientific article published on 15 March 2016

Pyrazin-2(1H)-ones as a novel class of selective A3 adenosine receptor antagonists

scientific article

Pyridazine derivatives 32: Stille-based approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones

scientific article published in April 2003

Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones

scientific article

Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors

scientific article

Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones

scientific article published on 01 December 2002

Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones

scientific article published in January 2004

Pyridazines. Part 37: Facile solution phase combinatorial synthesis of highly substituted pyridazin-3-ones

scientific article published on 01 January 2004

Pyridazines. Part XXIX: synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions.

scientific article

Pyridazines. XIII. Synthesis of 6-aryl-5-oxygenated substituted-3(2H)-pyridazinones and evaluation as platelet aggregation inhibitors

scientific article published on 01 July 1997

Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists

scientific article published on 27 December 2010

Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold

scientific article

Silica-supported aluminum chloride-assisted solution phase synthesis of pyridazinone-based antiplatelet agents

scientific article published on 09 November 2010

Special Issue: Adenosine Receptors.

scientific article

Straightforward entry to libraries of diversely substituted azinones by a consecutive aza-Michael/palladium-catalyzed functionalization strategy

scientific article published in May 2006

Straightforward three-component palladium-catalysed synthesis of pyridazin-3(2H)-one libraries

scientific article published in January 2006

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms

scientific article published in December 2017

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors

scientific article published on 10 November 2017

Structure-Based Rational Design of Adenosine Receptor Ligands

scientific article

Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction

scientific article

Supported p-toluenesulfonic acid as a highly robust and eco-friendly isocyanide scavenger

scientific article published on 10 November 2010

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

scientific article

Synthesis of 1-substituted-6-methyluracils

scientific article published in September 2003

Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines

scientific article published on 24 January 2008

Synthetic applications of polystyrene-supported 1,1,3,3-tetramethylguanidine

scientific article

Three-component assembly of structurally diverse 2-aminopyrimidine-5-carbonitriles.

scientific article

Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition

scientific article published on 04 October 2019

Ugi-based approaches to quinoxaline libraries.

scientific article

List of works by Eddy Sotelo

1,5-dimethyl-6H-pyridazino[4,5-b]carbazole, a 3-aza bioisoster of the antitumor alkaloid olivacine

1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor

2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies

3,4-Dihydropyrimidin-2(1<i>H</i>)-ones as Antagonists of the Human A<sub>2B</sub> Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition

5-amino-6-phenyl-1,6-dihydropyridazin-3(2H)-one

8-Substituted-9-deazaxanthines as adenosine receptor ligands: design, synthesis and structure-affinity relationships at A2B.

A novel quantitative multiplex real-time RT-PCR for the simultaneous detection and differentiation of West Nile virus lineages 1 and 2, and of Usutu virus ⬇️

Click chemistry approach to assembly proline mimetic libraries containing 1,4-substituted 1,2,3-triazoles

Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke

Computer-aided design of GPCR ligands

Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases

Convergent assembly of structurally diverse quinazolines

Copper-catalyzed Huisgen 1,3-dipolar cycloaddition under oxidative conditions: polymer-assisted assembly of 4-acyl-1-substituted-1,2,3-triazoles

Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Abeta1-40 aggregation in vitro

Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor

Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity

Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors

Discovery and preliminary SAR of 5-arylidene-2,2-dimethyl-1,3-dioxane- 4,6-diones as platelet aggregation inhibitors

Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists

Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes

Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists

Drug structural features affect drug delivery from hyperbranched polyesteramide hot melt extrudates

Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists

Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

Expanding the chemical diversity of azinone libraries by a consecutive alkylation/palladium-catalyzed functionalization strategy

Free-Energy Calculations for Bioisosteric Modifications of A3 Adenosine Receptor Antagonists

Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones

Multicomponent Assembly of the Kinesin Spindle Protein Inhibitor CPUYJ039 and Analogues as Antimitotic Agents.

Multicomponent assembly of diverse pyrazin-2(1H)-one chemotypes

Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells

Personality traits in patients with cluster headache: a comparison with migraine patients.

Pyrazin-2(1H)-ones as a novel class of selective A3 adenosine receptor antagonists

Pyridazine derivatives 32: Stille-based approaches in the synthesis of 5-substituted-6-phenyl-3(2H)-pyridazinones

Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones

Pyridazines. Part 28: 5-alkylidene-6-phenyl-3(2H)-pyridazinones, a new family of platelet aggregation inhibitors

Pyridazines. Part 31: synthesis and antiplatelet activity of 4,5-disubstituted-6-phenyl-3(2H)-pyridazinones

Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones

Pyridazines. Part 37: Facile solution phase combinatorial synthesis of highly substituted pyridazin-3-ones

Pyridazines. Part XXIX: synthesis and platelet aggregation inhibition activity of 5-substituted-6-phenyl-3(2H)-pyridazinones. Novel aspects of their biological actions.

Pyridazines. XIII. Synthesis of 6-aryl-5-oxygenated substituted-3(2H)-pyridazinones and evaluation as platelet aggregation inhibitors

Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists

Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold

Silica-supported aluminum chloride-assisted solution phase synthesis of pyridazinone-based antiplatelet agents

Special Issue: Adenosine Receptors.

Straightforward entry to libraries of diversely substituted azinones by a consecutive aza-Michael/palladium-catalyzed functionalization strategy

Straightforward three-component palladium-catalysed synthesis of pyridazin-3(2H)-one libraries

Structural Mapping of Adenosine Receptor Mutations: Ligand Binding and Signaling Mechanisms

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors

Structure-Based Rational Design of Adenosine Receptor Ligands

Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction

Supported p-toluenesulfonic acid as a highly robust and eco-friendly isocyanide scavenger

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid.

Synthesis of 1-substituted-6-methyluracils

Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines

Synthetic applications of polystyrene-supported 1,1,3,3-tetramethylguanidine

Three-component assembly of structurally diverse 2-aminopyrimidine-5-carbonitriles.

Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidence of Stereospecific Recognition

Ugi-based approaches to quinoxaline libraries.