Search filters

List of works by Toshihiro Sugiyama

A multi-organ loss of tissue phenotype in COPD: involvement of the functional muscle–bone unit

article published in 2018

Adaptation of Bone to Mechanical Strain

scientific article published on 11 December 2017

Adaptation of bone to mechanical loads

scientific article published in The Lancet

Age-related fragility fracture: insights from the natural homeostatic system in the skeleton

article

Age-related impairment of bones' adaptive response to loading in mice is associated with sex-related deficiencies in osteoblasts but no change in osteocytes

scientific article

An evidence-based perspective on vitamin D and the growing skeleton

article

An evidence-based perspective on warfarin and the growing skeleton

article

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces i

article

Association of proton pump inhibitors with fracture risk in patients with rheumatoid arthritis

scientific article published on 31 May 2019

Bariatric Surgery, Physical Activity, and Fracture Risk

scientific article published on 05 November 2018

Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition

scientific article

Both falling and bone fragility should be targeted to prevent hip fracture in older adults

Calcium, proton pump inhibitors, and fracture risk

article

Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K.

scientific article published in January 2001

Changes in bone biochemical markers after high-dose cerivastatin treatment in a woman with osteogenesis imperfecta

scientific article published in January 2001

Chronic kidney disease and fracture risk: a mechanistic insight

scientific article published on 01 July 2019

Cortical stability of the femoral neck and hip fracture risk

scientific article published in The Lancet

Dexamethasone induces human spinal ligament derived cells toward osteogenic differentiation

scientific article

Edoxaban Versus Warfarin

Effects of High-Dose Vitamin D Supplementation on Bone Fragility

scientific article published on 02 November 2020

Effects of bisphosphonate treatment on bone repair under immunosuppression using cyclosporine A in adult rats

Effects of cerivastatin on vascularized allogenic bone transplantation in rats treated with cyclosporine A.

scientific article published on 18 October 2002

Effects of cessation of immunosuppression on skeleton reconstructed by vascularized bone allograft in rats

scientific article published on 01 March 2004

Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the "mechanostat" theory

scientific article

Effects of vitamin D analog, 22-oxa-1,25-dihydroxyvitamin D(3), on bone reconstruction by vascularized bone allograft

scientific article published in February 2002

Estrogen Receptors Critically Regulate Bones’ Adaptive Responses to Loading

article

Estrogen receptor α mediates proliferation of osteoblastic cells stimulated by estrogen and mechanical strain, but their acute down-regulation of the Wnt antagonist Sost is mediated by estrogen receptor β.

scientific article published on 29 January 2013

Exercise for the skeleton in postmenopausal women: fundamental rules of mechanical strain-related stimulus

Folate and vitamin B12 for hip fracture prevention after stroke

scientific article published in August 2005

Fracture risk after bariatric surgery: a possible involvement of physical activity

Full 24-month treatment course with daily teriparatide: a mechanistic insight

article by Toshihiro Sugiyama et al published 6 May 2016 in Osteoporosis International

Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones

scientific article

Gestational vitamin D and childhood bone health.

scientific article

Growth and bone mineral density in a child with X-linked hypophosphatemic rickets: Early response to treatment

scientific article published on 01 January 1999

Hip fracture risk in patients with atrial fibrillation receiving oral anticoagulants

scientific article published on 07 May 2020

Hyperleptinemia in Female Patients with Ossification of Spinal Ligaments

article published in 2000

Hypertrophy of Vascularized Bone Isograft in Rats Treated with Cyclosporine A

scientific article published in 2003

IGF-I-Deficient Mice: Role in Skeletal Adaptation to Load

Improvement of periarticular osteoporosis in postmenopausal women with rheumatoid arthritis by β-alanyl- l -histidinato zinc: a pilot study

scientific article published on 01 January 2000

Improvement of skeletal fragility by teriparatide in adult osteoporosis patients: a novel mechanostat-based hypothesis for bone quality

scientific article

Improving Hip Fragility by Nitrates: A Mechanistic Insight

Infliximab and the bone in Crohn's disease

Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol

scientific article published in February 2001

Involvement of bone morphogenic protein‐2 (BMP‐2) in the pathological ossification process of the spinal ligament

scientific article published on 01 October 2001

Involvement of interleukin-6 and prostaglandin E2 in periarticular osteoporosis of postmenopausal women with rheumatoid arthritis

scientific article

Letter by Sugiyama Regarding Article, "Screening and Treatment for Osteoporosis After Stroke: Results From the Ontario Stroke Registry"

scientific article published on 13 September 2019

Letter to the Editor: "Comparison of Teriparatide and Denosumab in Patients Switching from Long-Term Bisphosphonate Use"

scientific article published on 01 December 2019

Letter to the Editor: "Exercise Mitigates Bone Loss in Women With Severe Obesity After Roux-en-Y Gastric Bypass: A Randomized Controlled Trial"

scientific article published on 01 March 2020

Letter to the Editor: "Further Nonvertebral Fracture Reduction Beyond 3 Years for Up to 10 Years of Denosumab Treatment"

scientific article published on 01 December 2019

Letter to the Editor: "Pharmacological Management of Osteoporosis in Postmenopausal Women: An Endocrine Society Clinical Practice Guideline"

scientific article published on 01 November 2019

Letter to the Editor: A Possible Mechanism of Denosumab Treatment for Fracture Prevention

Letter to the Editor: Association Between Body Mass Index and Hip Fragility in Older Adults

Letter to the Editor: Bone Health and Denosumab Treatment in Autoimmune Liver Diseases: A Possible Involvement of Physical Activity

scientific article published on 05 March 2020

Letter to the Editor: Bone Health in Nonalcoholic Fatty Liver Disease: A Mechanistic Insight

scientific article published on 01 November 2019

Letter to the Editor: Combination Treatment With Teriparatide and Denosumab in Osteoporosis

Letter to the Editor: Skeletal Fragility Following Bariatric Surgery: A Mechanistic Insight

Letter to the Editor: Strontium Ranelate in the Treatment of Osteoporosis: A Possible Mechanism

scholarly article by Toshihiro Sugiyama et al published May 2016 in The Journal of Clinical Endocrinology and Metabolism

Letter to the Editor: Vitamin D Deficiency and Fractures in Children: A Mechanistic Point of View

Letter to the Editor: “Effects of Long-Term Denosumab on Bone Histomorphometry and Mineralization in Women With Postmenopausal Osteoporosis”

scholarly article by Toshihiro Sugiyama published 15 May 2018 in The Journal of Clinical Endocrinology and Metabolism

Letter: association between proton pump inhibitor use and fracture risk - causality or confounding?

Letter: bone fracture risk among older long-term users of proton pump inhibitors

scientific article published on 01 July 2020

Letter: proton pump inhibitor use and fracture risk

scientific article published in February 2018

Male mice housed in groups engage in frequent fighting and show a lower response to additional bone loading than females or individually housed males that do not fight

scientific article published on 26 January 2013

Maternal vitamin D status during pregnancy and bone-mineral content in offspring

scientific article published in The Lancet

Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1-34) on trabecular and cortical bone in mice

scientific article published in May 2008

Mechanical loading-related bone gain is enhanced by tamoxifen but unaffected by fulvestrant in female mice

scientific article

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

scientific article published on 15 May 2011

Menatetrenone plus alfacalcidol treatment for bone problems in eight children with skeletal unloading

scientific article published on 01 January 2000

Not only vitamin D but also statin may be a good choice in the management of patients undergoing transplantation

scientific article published on 01 February 2004

Observational studies investigating hip fracture risk: a fundamental methodological issue?

Optimal dosing of zoledronate to prevent fractures: improving risk-benefit balance

scientific article published on 29 April 2019

Oral anticoagulation and hip fracture risk: a common misconception?

Osteoporosis Therapy: Bone Modeling during Growth and Aging

scientific article published on 09 March 2017

Osteoporosis therapy: a novel insight from natural homeostatic system in the skeleton

scientific article published on 07 October 2014

Osteoporotic Fractures Associated With Dabigatran vs Warfarin

scientific article

Physical activity and bone health: understanding mechanical strain-related stimuli

article

Poor Vitamin K Status in Chronic Kidney Disease: An Indirect Indicator of Hip Fragility

scientific article published on 03 July 2019

Possible Involvements of Vitamin K in Bone Quality

scientific article published on 01 January 2007

Possible different roles of exercise in preventing vertebral and hip fractures

article published in 2016

Possible involvement of vitamin D receptor gene polymorphism in male patients with ossification of spinal ligaments

scientific article

Proton Pump Inhibitor Therapy and Fracture Risk: Discrepancy of Results Between Observational and Interventional Studies

scientific article published on 23 January 2020

Proton Pump Inhibitor Use and Fracture Risk: An Update of Drug Safety Communication Needed?

scientific article published on 01 February 2019

Proton Pump Inhibitors and Hip Strength

Proton pump inhibitors and fracture: they impair bone quality and increase fall risk?

Quantitative ultrasound, skeletal quality, and fracture risk

scientific article published in March 2004

RE: "Vitamin D and fracture risk in Early childhood: a case-control study".

scientific article published on 6 February 2018

Regulation of bone mass: Local control or systemic influence or both?

Response to Lai "Proton Pump Inhibitors and Fracture Risk"

scientific article published on 01 October 2019

Risedronate does not reduce mechanical loading-related increases in cortical and trabecular bone mass in mice

scientific article

Role of endocrine and paracrine factors in the adaptation of bone to mechanical loading

scientific article published on June 2011

Romosozumab and blosozumab: alternative drugs of mechanical strain-related stimulus toward a cure for osteoporosis

scientific article published on 21 April 2015

Screening for Vitamin D Deficiency

Sequential treatment with intermittent low-dose human parathyroid hormone (1-34) and bisphosphonate enhances large-size skeletal reconstruction by vascularized bone transplantation

scientific article published in August 2007

Skeletal Adaptation to Mechanical Strain: A Key Role in Osteoporosis

article published in 2016

Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats

scientific article published in September 2003

Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

scientific article

Spontaneous fractures and quality of life in cerebral palsy

scientific article published in The Lancet

The Use of Vitamin K May Be a Good Choice for Microgravity-Induced Bone Disorder

article published in 2001

The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice

scientific article published on 14 February 2012

The mouse fibula as a suitable bone for the study of functional adaptation to mechanical loading

scientific article published on 14 January 2009

Towards a Consensus on Vitamin D Supplementation and Bone Health

scientific article published on 07 February 2019

Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women

Understanding bone fragility: theoretical explanation to non-physician health professionals

scientific article published on 19 June 2020

Understanding the Current Evidence on Proton Pump Inhibitor Use and Bone Health

scientific article published on 15 May 2019

Vibration and Components of Bone Strength

article

Vitamin D and Calcium Supplementation to Prevent Fractures in Adults

Vitamin D and bone health: interpreting observational studies

scientific article published on 17 July 2017

Vitamin D and bone health: key involvement of physical activity

article

Vitamin D and skeletal health during growth: the functional muscle-bone unit

article

Vitamin D status and bone health in obesity: another mechanistic point of view

article

Vitamin D status and bone health: a possible inverse association

scientific article published on 11 January 2019

Vitamin D supplementation and fracture risk in adults: a new insight

Vitamin K Plus Vitamin D Treatment of Bone Problems in a Child with Skeletal Unloading

Warfarin use and fracture risk: an evidence-based mechanistic insight

article

Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli

scholarly article by Toshihiro Sugiyama et al published 1 July 2007 in Journal of Endocrinology

Paulina is supported by:

About Paulina

Help