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List of works by Naofumi Mukaida

A novel regulatory mechanism of Pim-3 kinase stability and its involvement in pancreatic cancer progression.

scientific article published on 28 October 2013

Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression

scientific article

Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.

scientific article published in March 2005

Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice

scientific article published on 01 January 2011

Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice.

scientific article

Accelerated hepatocellular carcinoma development in mice expressing the Pim-3 transgene selectively in the liver

scientific article published on 18 January 2010

Ag and IL-2 immune complexes efficiently expand Ag-specific Treg cells that migrate in response to chemokines and reduce localized immune responses.

scientific article published on 13 January 2014

Alveolar Macrophages Drive Hepatocellular Carcinoma Lung Metastasis by Generating Leukotriene B4.

scientific article

Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC Chemokine ligand 3/macrophage inflammatory protein-1alpha.

scientific article published on 27 July 2010

Attenuated liver tumor formation in the absence of CCR2 with a concomitant reduction in the accumulation of hepatic stellate cells, macrophages and neovascularization.

scientific article

Blockade of CCR2 ameliorates progressive fibrosis in kidney.

scientific article

Blockade of a chemokine, CCL2, reduces chronic colitis-associated carcinogenesis in mice.

scientific article

Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation.

scientific article published on 22 June 2016

Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis

scientific article

CCL2-Mediated Reversal of Impaired Skin Wound Healing in Diabetic Mice by Normalization of Neovascularization and Collagen Accumulation

scientific article published on 24 June 2019

CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations

scientific article published on 06 April 2013

CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status

scientific article

Cancer Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor Is Dispensable for the Progression of 4T1 Murine Breast Cancer ⬇️

scientific article published on 16 December 2019

Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

scientific article published on 07 December 2018

Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis.

scientific article published on 24 October 2012

Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice.

scientific article

Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia.

scientific article

Chemokines in cancer development and progression and their potential as targeting molecules for cancer treatment

scientific article published on 22 May 2014

Chemokines in chronic myeloid leukemia

scientific article published in January 2016

Chemokines in tumor development and progression.

scientific article published on 21 October 2011

Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma: clinical safety

scientific article published on 01 February 2007

Contribution of the TNF-α (Tumor Necrosis Factor-α)-TNF-Rp55 (Tumor Necrosis Factor Receptor p55) Axis in the Resolution of Venous Thrombus

scientific article published on 01 November 2018

Correction: mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells

scientific article published in 2011

Critical role of TNF-α-induced macrophage VEGF and iNOS production in the experimental corneal neovascularization.

scientific article published on 14 June 2012

Crucial contribution of thymic Sirp alpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner

scientific article published on 12 August 2009

Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice

scientific article published on 20 February 2014

Crucial involvement of tumor-associated neutrophils in the regulation of chronic colitis-associated carcinogenesis in mice

scientific article

Cytoplasmic DNA accumulation preferentially triggers cell death of myeloid leukemia cells by interacting with intracellular DNA sensing pathway

scientific article published on 26 March 2021

DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization

scientific article published on 21 July 2016

Design and synthesis of an in vivo-efficacious PIM3 kinase inhibitor as a candidate anti-pancreatic cancer agent.

scientific article published on 31 October 2015

Dexamethasone impairs pulmonary defence againstPseudomonas aeruginosathrough suppressing iNOS gene expression and peroxynitrite production in mice ⬇️

scientific article published on November 1, 2001

Displays of paternal mouse pup retrieval following communicative interaction with maternal mates ⬇️

scientific article published on January 1, 2013

ERβ and PEA3 co-activate IL-8 expression and promote the invasion of breast cancer cells.

scientific article published on March 2011

Efficient generation of highly immunocompetent dendritic cells from peripheral blood of patients with hepatitis C virus-related hepatocellular carcinoma.

scientific article published on 2 June 2014

Emergence of Cancer-Associated Fibroblasts as an Indispensable Cellular Player in Bone Metastasis Process

scientific article published on 09 October 2020

Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma.

scientific article

Enhanced airway inflammation and decreased subepithelial fibrosis in interleukin 6-deficient mice following chronic exposure to aerosolized antigen.

scientific article

Enhanced anti-tumor effects of herpes simplex virus thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant protein-1 in hepatocellular carcinoma ⬇️

scientific article published on October 1, 2001

Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist

scientific article

Enhancement of tumor-specific T-cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma

article

Erratum to 'Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression' [Antiviral Research (2017) 15-19]

scientific article published on 01 March 2018

Essential contribution of Ets-1 to constitutive Pim-3 expression in human pancreatic cancer cells.

scientific article

Essential contribution of a chemokine, CCL3, and its receptor, CCR1, to hepatocellular carcinoma progression

scientific article

Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis

scientific article published on 01 September 2008

Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration

scientific article published on 4 December 2017

Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration.

scientific article published on March 2007

Exacerbation of granuloma formation in IL-1 receptor antagonist-deficient mice with impaired dendritic cell maturation associated with Th2 cytokine production.

scientific article published in March 2005

Fas ligand induces cell-autonomous NF-kappaB activation and interleukin-8 production by a mechanism distinct from that of tumor necrosis factor-alpha.

scientific article published on 26 August 2004

Fibroblasts, an inconspicuous but essential player in colon cancer development and progression

scientific article

Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney

scientific article published on 31 March 2011

Gemcitabine induces cell senescence in human pancreatic cancer cell lines

scientific article published on 13 June 2016

Gemcitabine-induced CXCL8 expression counteracts its actions by inducing tumor neovascularization.

scientific article

Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis.

scientific article published in April 2004

High-dose cyclophosphamide induces specific tumor immunity with concomitant recruitment of LAMP1/CD107a-expressing CD4-positive T cells into tumor sites

scientific article

Human cytomegalovirus replication supported by virus-induced activation of CCL2-CCR2 interactions

scientific article published on 26 September 2014

IFN-inducible protein 10 (CXCL10) regulates tubular cell proliferation in renal ischemia-reperfusion injury

scientific article published on 03 June 2008

IL-1beta induces IL-8 in bronchial cells via NF-kappaB and NF-IL6 transcription factors and can be suppressed by glucocorticoids.

scientific article published on 17 March 2005

IL17RB expression might predict prognosis and benefit from gemcitabine in patients with resectable pancreatic cancer

scientific article published on 17 September 2019

Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity.

scientific article published on 7 November 2011

Implication of "Down syndrome cell adhesion molecule" in the hippocampal neurogenesis of ischemic monkeys

scientific article published in January 2006

Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.

scientific article published on 21 February 2013

Inhibition of human cytomegalovirus replication by tricin is associated with depressed CCL2 expression

scientific article published on 28 September 2017

Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression.

scientific article published on October 2006

Interferon-γ is protective in cisplatin-induced renal injury by enhancing autophagic flux

scientific article published on 11 July 2012

Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells.

scientific article published on August 2004

Intrahepatic interleukin-8 production during disease progression of chronic hepatitis C

scientific article published on 19 January 2007

Involvement of a Transcription factor, Nfe2, in Breast Cancer Metastasis to Bone

scientific article published on 16 October 2020

Involvement of prokineticin 2-expressing neutrophil infiltration in 5-fluorouracil-induced aggravation of breast cancer metastasis to lung.

scientific article published on 11 April 2018

Lung Macrophages: Multifunctional Regulator Cells for Metastatic Cells ⬇️

journal article from 'International Journal of Molecular Sciences' published in 2019

Lysophosphatidic acid receptor LPAR6 supports the tumorigenicity of hepatocellular carcinoma

scientific article

MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice

scientific article

MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia

scientific article published on 28 October 2013

MRP-1 expression levels determine strain-specific susceptibility to sodium arsenic-induced renal injury between C57BL/6 and BALB/c mice

scientific article published in February 2005

Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells

scientific article

Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma ⬇️

scientific article published on March 9, 2012

Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancer.

scientific article published on 8 February 2012

MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine.

scientific article

Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas

scientific article

Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas.

scientific article published on April 2003

Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment

scientific article published on November 2005

Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpα+ dendritic cells: a murine model.

scientific article

Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury.

scientific article

PPARalpha activation abolishes LDL-stimulated IL-8 production via AP-1 deactivation in human aortic smooth muscle cells.

scientific article published in May 2004

Pathophysiological roles of Pim-3 kinase in pancreatic cancer development and progression.

scientific article

Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing ⬇️

scientific article published on January 3, 2012

Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis

scientific article published on 31 August 2004

Prevention of CaCl2-induced aortic inflammation and subsequent aneurysm formation by the CCL3-CCR5 axis

scientific article published on 25 November 2020

Prevention of intrahepatic metastasis of liver cancer by suicide gene therapy and chemokine ligand 2/monocyte chemoattractant protein-1 delivery in mice

scientific article published on December 2010

Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice

scientific article published in PLoS ONE

Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization

scientific article published on 19 November 2010

Protective Roles of Interferon-γ in Cardiac Hypertrophy Induced by Sustained Pressure Overload.

scientific article published on 19 March 2018

Protective roles of CX3CR1-mediated signals in toxin A-induced enteritis through the induction of heme oxygenase-1 expression.

scientific article published on 3 December 2010

Protective roles of the fractalkine/CX3CL1-CX3CR1 interactions in alkali-induced corneal neovascularization through enhanced antiangiogenic factor expression

scientific journal article

Protein kinase R, IkappaB kinase-beta and NF-kappaB are required for human rhinovirus induced pro-inflammatory cytokine production in bronchial epithelial cells

scientific article published on 20 September 2006

Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis

scientific article

Publisher Correction: Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

scientific article published on 16 April 2020

RETRACTED: Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells

scientific article

Redistributions of macrophages expressing the macrophage galactose-type C-type lectin (MGL) during antigen-induced chronic granulation tissue formation.

scientific article published on 31 March 2005

Reduced acetaminophen-induced liver injury in mice by genetic disruption of IL-1 receptor antagonist.

scientific article

Regulation of stimulus-induced interleukin-8 gene transcription in human adrenocortical carcinoma cells - Role of AP-1 and NF-κB

scientific article published on 18 October 2019

Resveratrol stimulation induces interleukin-8 gene transcription via NF-κB

scientific article published on 06 July 2018

Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

scientific article published on 12 June 2019

Retraction: Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells

scientific article published in 2011

Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production

scientific article published on 01 December 2004

Role of macrophage inflammatory protein (MIP)-1α/CCL3 in leukemogenesis.

scientific article published on 15 July 2014

Roles of Pim‐3, a novel survival kinase, in tumorigenesis ⬇️

scientific article published on May 23, 2011

Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cells.

scientific article published on August 2010

Splicing inhibition induces gene expression through canonical NF-κB pathway and extracellular signal-related kinase activation

scientific article published on 20 February 2014

Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55

scientific article published on 01 December 2004

Stimulation of transient receptor potential M3 (TRPM3) channels increases interleukin-8 gene promoter activity involving AP-1 and extracellular signal-regulated protein kinase.

scientific article published on 2 October 2017

Suppressed rate of carcinogenesis and decreases in tumour volume and lung metastasis in CXCL14/BRAK transgenic mice

scientific article

TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.

scientific article published on 26 August 2013

The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation

scientific article

Tumor Necrosis Factor (TNF) and Chemokines in Colitis-Associated Cancer

scientific article published on 27 June 2011

Two-Faced Roles of Tumor-Associated Neutrophils in Cancer Development and Progression ⬇️

scientific article published on 14 May 2020

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra

scientific article published on 14 October 2019

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