List of works - Lionel Bretillon

24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma ⬇️

scientific article published on April 21, 2011

A dietary combination of omega-3 and omega-6 polyunsaturated fatty acids is more efficient than single supplementations in the prevention of retinal damage induced by elevation of intraocular pressure in rats.

scientific article

A mouse model of in vivo chemical inhibition of retinal calcium-independent phospholipase A2 (iPLA2) ⬇️

scientific article published on December 21, 2012

ALDH1A3 mutations cause recessive anophthalmia and microphthalmia

scientific article published on 9 January 2013

Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland

scientific article published on 02 April 2009

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

scientific article

ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina

scientific article

Apprehending ganglioside diversity: a comprehensive methodological approach

scientific article

Beneficial effects of myocardial postconditioning are associated with reduced oxidative stress in a senescent mouse model

scientific article published in June 2008

Branched-chain fatty acids, increased in tears of blepharitis patients, are not toxic for conjunctival cells

scientific article

Cellular and Molecular Connections between Autophagy and Inflammation

scientific article

Changes in meibomian fatty acids and clinical signs in patients with meibomian gland dysfunction after minocycline treatment

scientific article published on 29 May 2008

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

scientific article published in October 2003

Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol.

scientific article published on 30 May 2017

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

scientific article

Comparative study of serine-plasmalogens in human retina and optic nerve: identification of atypical species with odd carbon chains.

scientific article published on 19 January 2012

Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells.

scientific article

Conversion of 18:3 delta 9cis, 12cis, 15trans in rat liver microsomes

scientific article published on 01 July 1997

Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression

scientific article

Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver

scientific article published on 01 November 1998

Dietary cyclic fatty acids derived from linolenic acid do not exhibit intrinsic toxicity in the rat during gestation.

scientific article published on October 2008

Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels

scientific article published on 26 February 2009

Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats ⬇️

scientific article published on April 1, 2011

Differences in meibomian fatty acid composition in patients with meibomian gland dysfunction and aqueous-deficient dry eye

article

Differential effect of maternal diet supplementation with alpha-Linolenic adcid or n-3 long-chain polyunsaturated fatty acids on glial cell phosphatidylethanolamine and phosphatidylserine fatty acid profile in neonate rat brains

scientific article

Early adaptive response of the retina to a pro-diabetogenic diet: Impairment of cone response and gene expression changes in high-fructose fed rats

scientific article published on 23 April 2015

Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro

scientific article published on 01 September 1999

Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model.

scientific article published on 5 May 2009

Erythrocyte phospholipid and polyunsaturated fatty acid composition in diabetic retinopathy

scientific article

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

scientific article published on 30 November 2020

Fatp1 deficiency affects retinal light response and dark adaptation, and induces age-related alterations.

scientific article

Fatty acid isomers in lipid metabolism.

scientific article published in January 2004

Functional and structural effect of intravitreal indocyanine green, triamcinolone acetonide, trypan blue, and brilliant blue g on rat retina

scientific article published in September 2010

Ganglioside Profiling of the Human Retina: Comparison with Other Ocular Structures, Brain and Plasma Reveals Tissue Specificities

scientific article

Identification and quantification of phosphatidylcholines containing very-long-chain polyunsaturated fatty acid in bovine and human retina using liquid chromatography/tandem mass spectrometry

scientific article published on 14 October 2010

Implantation of the Auditory Nerve via the Middle Ear Cavity in Rats with Partial Hearing Preservation

scientific article published on 25 March 2016

In situ hybridization of dihydroxyacetone phosphate acyltransferase, the regulating enzyme involved in plasmalogen biosynthesis

scientific article published in May 2005

In vitro desaturation or elongation of monotrans isomers of linoleic acid by rat liver microsomes

scientific article published on 01 August 1998

In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina

scientific article published in February 2014

In vivo oxidation of [9-14C] cyclic fatty acids derived from linolenic acid in the rat

scientific article published on 01 March 2006

In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat.

scientific article

Incorporation of lutein and docosahexaenoic acid from dietary microalgae into the retina in quail

scientific article published on 06 February 2015

Influence of rosuvastatin on the NAD(P)H oxidase activity in the retina and electroretinographic response of spontaneously hypertensive rats.

scientific article published on 18 June 2007

Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma

scientific article published on 09 June 2020

Involvement of plasmalogens in post-natal retinal vascular development

scientific article

Isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men.

scientific article published in June 2001

Lack of Dietary Polyunsaturated Fatty Acids Causes Synapse Dysfunction in the Drosophila Visual System.

scientific article published on 26 August 2015

Lipid and fatty acid profile of the retina, retinal pigment epithelium/choroid, and the lacrimal gland, and associations with adipose tissue fatty acids in human subjects

scientific article

Lipid composition of the human eye: are red blood cells a good mirror of retinal and optic nerve fatty acids?

scientific article

Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat

scientific article

Metabolites of conjugated isomers of alpha-linolenic acid (CLnA) in the rat.

scientific article published in March 2005

Might analysis, synthesis and metabolism of CLA contribute to explain the biological effects of CLA?

scientific article

Modulation of brain PUFA content in different experimental models of mice

scientific article published on 30 September 2016

No consequences of dietary n-3 polyunsaturated fatty acid deficiency on the severity of scopolamine-induced dry eye.

scientific article published on 16 December 2010

No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study

scientific article

Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation.

scientific article

Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.

scientific article

Ocular surface assessment in soft contact lens wearers; the contribution of tear osmolarity among other tests

scientific article

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

scientific article (publication date: 13 November 2001)

Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium

scientific article

Oxidation-Induced Increase In Photoreactivity of Bovine Retinal Lipid Extract.

scientific article

Oxidative metabolism of [1-14C] mono-trans isomers of linoleic and alpha-linolenic acids in the rat.

scientific article published in February 1998

Oxysterols Induced Inflammation and Oxidation in Primary Porcine Retinal Pigment Epithelial Cells

scientific article published on 01 March 2007

Oxysterols: Influence on plasma membrane rafts microdomains and development of ocular diseases

scientific article

Pantethine Alters Lipid Composition and Cholesterol Content of Membrane Rafts, With Down-Regulation of CXCL12-Induced T Cell Migration

scientific article

Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding

scientific article published on 15 December 2014

Peroxisome proliferator-activated receptor alpha is not the exclusive mediator of the effects of dietary cyclic FA in mice

scientific article published in September 2003

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

scientific article published in October 2000

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

article

Plasmalogens in the retina: In situ hybridization of dihydroxyacetone phosphate acyltransferase (DHAP-AT) – the first enzyme involved in their biosynthesis – and comparative study of retinal and retinal pigment epithelial lipid composition

article

Plasmatic Ganglioside Profile and Age-Related Macular Degeneration: A Case-Control Study

scientific article published on 2 April 2016

Polyunsaturated fatty acids induce modification in the lipid composition and the prostaglandin production of the conjunctival epithelium cells

scientific article

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

scientific article

Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells

scientific article

Red blood cell plasmalogens and docosahexaenoic acid are independently reduced in primary open-angle glaucoma

scientific article published on 21 July 2009

Retinas of the diurnal rodent Arvicanthis ansorgei are highly resistant to experimentally induced stress and degeneration

scientific article published on 7 November 2011

Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice.

scientific article

Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration

scientific article published on 09 October 2012

Steady‐state levels of retinal 24S‐hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat ⬇️

scientific article published on September 23, 2012

The Montrachet Study: study design, methodology and analysis of visual acuity and refractive errors in an elderly population

scientific article published on 15 October 2015

The hedgehog receptor patched is involved in cholesterol transport

scientific article

The ins and outs of cholesterol in the vertebrate retina.

scientific article

The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid

scientific article published on 23 September 2006

Time course of ocular surface and lacrimal gland changes in a new scopolamine-induced dry eye model

scientific article

List of works by Lionel Bretillon

24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma ⬇️

A dietary combination of omega-3 and omega-6 polyunsaturated fatty acids is more efficient than single supplementations in the prevention of retinal damage induced by elevation of intraocular pressure in rats.

A mouse model of in vivo chemical inhibition of retinal calcium-independent phospholipase A2 (iPLA2) ⬇️

ALDH1A3 mutations cause recessive anophthalmia and microphthalmia

Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland

Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.

ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina

Apprehending ganglioside diversity: a comprehensive methodological approach

Beneficial effects of myocardial postconditioning are associated with reduced oxidative stress in a senescent mouse model

Branched-chain fatty acids, increased in tears of blepharitis patients, are not toxic for conjunctival cells

Cellular and Molecular Connections between Autophagy and Inflammation

Changes in meibomian fatty acids and clinical signs in patients with meibomian gland dysfunction after minocycline treatment

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Cholesterol metabolism and glaucoma: Modulation of Muller cell membrane organization by 24S-hydroxycholesterol.

Cholesterol-24S-hydroxylase (CYP46A1) is specifically expressed in neurons of the neural retina

Comparative study of serine-plasmalogens in human retina and optic nerve: identification of atypical species with odd carbon chains.

Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells.

Conversion of 18:3 delta 9cis, 12cis, 15trans in rat liver microsomes

Decreasing dietary linoleic acid promotes long chain omega-3 fatty acid incorporation into rat retina and modifies gene expression

Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver

Dietary cyclic fatty acids derived from linolenic acid do not exhibit intrinsic toxicity in the rat during gestation.

Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels

Dietary polyunsaturated fatty acids reduce retinal stress induced by an elevation of intraocular pressure in rats ⬇️

Differences in meibomian fatty acid composition in patients with meibomian gland dysfunction and aqueous-deficient dry eye

Differential effect of maternal diet supplementation with alpha-Linolenic adcid or n-3 long-chain polyunsaturated fatty acids on glial cell phosphatidylethanolamine and phosphatidylserine fatty acid profile in neonate rat brains

Early adaptive response of the retina to a pro-diabetogenic diet: Impairment of cone response and gene expression changes in high-fructose fed rats

Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro

Efficacy of a 2-month dietary supplementation with polyunsaturated fatty acids in dry eye induced by scopolamine in a rat model.

Erythrocyte phospholipid and polyunsaturated fatty acid composition in diabetic retinopathy

Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

Fatp1 deficiency affects retinal light response and dark adaptation, and induces age-related alterations.

Fatty acid isomers in lipid metabolism.

Functional and structural effect of intravitreal indocyanine green, triamcinolone acetonide, trypan blue, and brilliant blue g on rat retina

Ganglioside Profiling of the Human Retina: Comparison with Other Ocular Structures, Brain and Plasma Reveals Tissue Specificities

Identification and quantification of phosphatidylcholines containing very-long-chain polyunsaturated fatty acid in bovine and human retina using liquid chromatography/tandem mass spectrometry

Implantation of the Auditory Nerve via the Middle Ear Cavity in Rats with Partial Hearing Preservation

In situ hybridization of dihydroxyacetone phosphate acyltransferase, the regulating enzyme involved in plasmalogen biosynthesis

In vitro desaturation or elongation of monotrans isomers of linoleic acid by rat liver microsomes

In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina

In vivo oxidation of [9-14C] cyclic fatty acids derived from linolenic acid in the rat

In vivo oxidation of carboxyl-labelled cyclic fatty acids formed from linoleic and linolenic acids in the rat.

Incorporation of lutein and docosahexaenoic acid from dietary microalgae into the retina in quail

Influence of rosuvastatin on the NAD(P)H oxidase activity in the retina and electroretinographic response of spontaneously hypertensive rats.

Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma

Involvement of plasmalogens in post-natal retinal vascular development

Isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men.

Lack of Dietary Polyunsaturated Fatty Acids Causes Synapse Dysfunction in the Drosophila Visual System.

Lipid and fatty acid profile of the retina, retinal pigment epithelium/choroid, and the lacrimal gland, and associations with adipose tissue fatty acids in human subjects

Lipid composition of the human eye: are red blood cells a good mirror of retinal and optic nerve fatty acids?

Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat

Metabolites of conjugated isomers of alpha-linolenic acid (CLnA) in the rat.

Might analysis, synthesis and metabolism of CLA contribute to explain the biological effects of CLA?

Modulation of brain PUFA content in different experimental models of mice

No consequences of dietary n-3 polyunsaturated fatty acid deficiency on the severity of scopolamine-induced dry eye.

No effect of dietary trans isomers of alpha-linolenic acid on platelet aggregation and haemostatic factors in european healthy men. The TRANSLinE study

Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation.

Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions.

Ocular surface assessment in soft contact lens wearers; the contribution of tear osmolarity among other tests

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Ophthalmic epidemiology in Europe: the "European Eye Epidemiology" (E3) consortium

Oxidation-Induced Increase In Photoreactivity of Bovine Retinal Lipid Extract.

Oxidative metabolism of [1-14C] mono-trans isomers of linoleic and alpha-linolenic acids in the rat.

Oxysterols Induced Inflammation and Oxidation in Primary Porcine Retinal Pigment Epithelial Cells

Oxysterols: Influence on plasma membrane rafts microdomains and development of ocular diseases

Pantethine Alters Lipid Composition and Cholesterol Content of Membrane Rafts, With Down-Regulation of CXCL12-Induced T Cell Migration

Perinatal high-fat diet increases hippocampal vulnerability to the adverse effects of subsequent high-fat feeding

Peroxisome proliferator-activated receptor alpha is not the exclusive mediator of the effects of dietary cyclic FA in mice

Plasma levels of 24S-hydroxycholesterol in patients with neurological diseases

Plasma levels of 24S-hydroxycholesterol reflect the balance between cerebral production and hepatic metabolism and are inversely related to body surface

Plasmalogens in the retina: In situ hybridization of dihydroxyacetone phosphate acyltransferase (DHAP-AT) – the first enzyme involved in their biosynthesis – and comparative study of retinal and retinal pigment epithelial lipid composition

Plasmatic Ganglioside Profile and Age-Related Macular Degeneration: A Case-Control Study

Polyunsaturated fatty acids induce modification in the lipid composition and the prostaglandin production of the conjunctival epithelium cells

Primary open-angle glaucoma: association with cholesterol 24S-hydroxylase (CYP46A1) gene polymorphism and plasma 24-hydroxycholesterol levels

Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells

Red blood cell plasmalogens and docosahexaenoic acid are independently reduced in primary open-angle glaucoma

Retinas of the diurnal rodent Arvicanthis ansorgei are highly resistant to experimentally induced stress and degeneration

Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice.

Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration

Steady‐state levels of retinal 24S‐hydroxycholesterol are maintained by glial cells intervention after elevation of intraocular pressure in the rat ⬇️