Search filters

List of works by Christopher G. Parsons

3-Nitropropionic acid toxicity in hippocampus: protection through N-methyl-D-aspartate receptor antagonism

scientific article published in January 2006

A Novel Series of 2-Carboxytetrahydroquinolines Provides New Insights into the Eastern Region of Glycine Site NMDA Antagonists

scientific article published on 01 August 2000

Agonist concentration dependency of blocking kinetics but not equilibrium block of N-methyl-D-aspartate receptors by memantine

scientific article

Alpha2-adrenoreceptor activation inhibits LTP and LTD in the basolateral amygdala: involvement of Gi/o-protein-mediated modulation of Ca2+-channels and inwardly rectifying K+-channels in LTD.

scientific article published in April 2003

Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization

scientific article published in January 1999

Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents--preclinical studies.

scientific article published on July 1997

Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor.

scientific article published on November 2003

Antipsychotic drugs antagonize human serotonin type 3 receptor currents in a noncompetitive manner.

scientific article published on September 2004

Anxiolytic activity of glycine-B antagonists and partial agonists--no relation to intrinsic activity in the patch clamp.

scientific article published in October 1997

Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats

scientific article published in April 2003

Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function.

scientific article published in December 2012

At which 'sigma' site are the spinal actions of ketamine mediated?

scientific article published in March 1988

Blocking kinetics of memantine on NR1a/2A receptors recorded in inside-out and outside-out patches from Xenopus oocytes.

scientific article

Brain concentrations of mGluR5 negative allosteric modulator MTEP in relation to receptor occupancy--Comparison to MPEP.

scientific article

Brain distribution of an uncompetitive NMDA receptor antagonist; comparison to its in vitro potency in electrophysiological studies

scientific article

Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist: patch clamp studies in cultured striatal, hippocampal, cortical and superior colliculus neurones

scientific article

Chronic memantine does not block 3-nitropropionic acid-delayed ischaemic tolerance in rat hippocampal slices ex vivo

scientific article published in January 2004

Chronic treatment with the uncompetitive NMDA receptor antagonist memantine influences the polyamine and glycine binding sites of the NMDA receptor complex in aged rats.

scientific article published in January 1995

Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methyl-endioxyl-5H-2,3-benzodiaze pine (GYKI 52466).

scientific article published in May 1994

Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine

scientific article

Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo

scientific article published on October 1995

Different binding affinities of NMDA receptor channel blockers in various brain regions—Indication of NMDA receptor heterogeneity

scientific article published on 01 May 1995

Differential effects of NMDA-receptor antagonists on long-term potentiation and hypoxic/hypoglycaemic excitotoxicity in hippocampal slices

scientific article (publication date: 14 February 2000)

Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain

scientific article

Effects of the uncompetitive NMDA receptor antagonist memantine on hippocampal long-term potentiation, short-term exploratory modulation and spatial memory in awake, freely moving rats

scientific article

Electrophysiological study, biodistribution in mice, and preliminary PET evaluation in a rhesus monkey of 1-amino-3-[18F]fluoromethyl-5-methyl-adamantane (18F-MEM): a potential radioligand for mapping the NMDA-receptor complex

scientific article published in May 1998

Expression of early hippocampal CA1 LTP does not lead to changes in AMPA-EPSC kinetics or sensitivity to cyclothiazide

scientific article

Expression of polyglutamine-expanded huntingtin induces tyrosine phosphorylation of N-methyl-D-aspartate receptors

scientific article

Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication.

scientific article

GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats

scientific article

GlycineB antagonists as potential therapeutic agents. Previous hopes and present reality

scientific article published in January 1998

GlycineB recognition site of NMDA receptors and its antagonists

scientific article published on 01 January 1998

Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole Scaffold

In vivo evidence for functional NMDA receptor blockade by memantine in rat hippocampal neurons.

scientific article published on 7 September 2010

Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors.

scientific article

Interactions of GYKI 52466 and NBQX with cyclothiazide at AMPA receptors: experiments with outside-out patches and EPSCs in hippocampal neurones

scientific article published in October 1998

Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantine

scientific article

Lipid raft integrity affects GABAA receptor, but not NMDA receptor modulation by psychopharmacological compounds

scientific article published on 10 December 2012

MRZ-99030 - A novel modulator of Aβ aggregation: I - Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD).

scientific article

Memantine and the amino-alkyl-cyclohexane MRZ 2/579 are moderate affinity uncompetitive NMDA receptor antagonists--in vitro characterisation.

scientific article

Memantine does not show intracellular block of the NMDA receptor channel

scientific article published on 4 April 2008

Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data

scientific article

Memantine restores long term potentiation impaired by tonic N-methyl-D-aspartate (NMDA) receptor activation following reduction of Mg2+ in hippocampal slices

scientific article published in September 1999

Memantine selectively depresses NMDA receptor-mediated responses of ratspinal neurones in vivo.

scientific article published in January 1994

Middle cerebral artery occlusion produces secondary, remote impairment in hippocampal plasticity of rats – involvement of N-methyl-d-aspartate receptors?

scientific article published on 01 March 2000

Modulation of NMDA receptors by glycine ? introduction to some basic aspects and recent developments

scientific article published on 01 January 1998

Modulation of fast excitatory synaptic transmission by cyclothiazide and GYKI 52466 in the rat hippocampus

scientific article published in July 1994

Mrz 2/579, a fast kinetic NMDA channel blocker, reduces the development of morphine tolerance in awake rats

scientific article

N-methyl-D-aspartate receptors mediate endogenous opioid release in enteric neurons after abdominal surgery

scientific article published in June 2005

NMDA receptors as targets for drug action in neuropathic pain.

scientific article published in October 2001

NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives

scientific article

Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo.

scientific article

Neuroprotective potential of ionotropic glutamate receptor antagonists.

scientific article

New allosteric modulators of metabotropic glutamate receptor 5 (mGluR5) found by ligand-based virtual screening

scientific article published in April 2005

Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies

article

Patch clamp combined with voltage/concentration clamp to determine the kinetics and voltage dependency of N-methyl-D-aspartate (NMDA) receptor open channel blockers

scientific article published on January 2014

Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan).

scientific article published in December 1993

Peripheral opioid receptors mediating antinociception in inflammation. Activation by endogenous opioids and role of the pituitary-adrenal axis.

scientific article published in April 1990

Peripherally acting NMDA receptor/glycineB site receptor antagonists inhibit morphine tolerance

scientific article

Pharmacodynamics of memantine: an update

scientific article

Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia

scientific article published on 16 December 2010

Positive and negative modulation of group I metabotropic glutamate receptors

scientific article

Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine

scientific article published on September 2006

Preclinical to phase II amyloid beta (Aβ) peptide modulators under investigation for Alzheimer's disease

scientific article published on 31 March 2017

Predicting compound selectivity by self-organizing maps: cross-activities of metabotropic glutamate receptor antagonists.

scientific article published in October 2006

Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists

Protection against post-ischaemic neuronal loss in gerbil hippocampal CA1 by glycine b and AMPA antagonists

scientific article published on 01 January 1997

Rationale for combining glutamatergic and cholinergic approaches in the symptomatic treatment of Alzheimer's disease

scientific article

Searching for drug scaffolds with 3D pharmacophores and neural network ensembles.

scientific article published in January 2007

Synergism of virtual screening and medicinal chemistry: identification and optimization of allosteric antagonists of metabotropic glutamate receptor 1.

scientific article published on 23 June 2009

Synthesis and structureâ affinity relationships of 1,3,5-alkylsubstituted cyclohexylamines binding at NMDA receptor PCP site

scientific article published on 01 June 2000

Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists

scientific article published on 06 August 2011

The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner

scientific article

The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801.

scientific article

The fraction of activated N-methyl-D-aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzole

scientific article published on 21 May 2008

The in vivo relevance of the varied channel-blocking properties of uncompetitive NMDA antagonists: tests on spinal neurones

scientific article published in July 2001

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

scientific article published on 12 February 2011

Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP.

scientific article published in July 1997

Virtual Screening for Selective Allosteric mGluR1 Antagonists and Structure–Activity Relationship Investigations for Coumarine Derivatives

scientific article published on 01 December 2007

Zinc changes AMPA receptor properties: Results of binding studies and patch clamp recordings

scientific article published on 01 April 1996

mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy

scientific article published on 24 March 2006

Paulina is supported by:

About Paulina

Help