List of works - Paul Robson

A core Klf circuitry regulates self-renewal of embryonic stem cells

scientific article published on 10 February 2008

A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.

scientific article published on June 2013

A path to translation: How 3D patient tumor avatars enable next generation precision oncology

scientific article published on 12 December 2022

Author Correction: Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

scientific article published in Nature Communications

BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures.

scientific article published on 31 October 2013

BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.

scientific article

Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape

scientific article

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

scientific article published on 25 March 2019

Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

scientific article published on 29 October 2020

Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

scientific article

Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells

scientific journal article

Conversion of Sox17 into a pluripotency reprogramming factor by reengineering its association with Oct4 on DNA

scientific article published on 01 June 2011

Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers

scientific article published on 16 November 2020

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

scientific article published on 13 June 2019

DNA-dependent Oct4-Sox2 interaction and diffusion properties characteristic of the pluripotent cell state revealed by fluorescence spectroscopy.

scientific article published in November 2012

Deciphering developmental processes from single-cell transcriptomes

scientific article published in May 2014

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.

scientific article published on 20 August 2015

Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through Fgf4/Fgfr2 signalling in preimplantation mouse embryos

scientific article published on 27 February 2018

Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells

scientific article

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.

scientific article published on February 2010

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

scientific article published on 5 January 2012

High throughput gene expression analysis identifies reliable expression markers of human corneal endothelial cells.

scientific article published on 02 July 2013

Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

scientific article published on 27 June 2016

Identification and characterization of a serpin with differential expression during the life cycle of the sea lamprey

scientific article published in June 1998

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.

scientific article

Inner cell mass-specific expression of a cell adhesion molecule (PECAM-1/CD31) in the mouse blastocyst

scientific article published in June 2001

Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer

scientific article

Mapping systemic lupus erythematosus heterogeneity at the single-cell level

scientific article published on 03 August 2020

Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance ⬇️

scientific article published on 01 March 2019

Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells

scientific article published on 7 March 2007

Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst

scientific article

Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm

scientific article published on 8 March 2013

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.

scientific article

Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures.

scientific article published on August 2005

Partial clone of the gene for AS protein of the lampreyPetromyzon marinus, a member of the albumin supergene family whose expression is restricted to the larval and metamorphic phases of the life cycle ⬇️

scientific article published on October 15, 1998

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

scientific article published on 21 January 2021

Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

scientific journal article

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

scientific article

Regulation of the murine Nfatc1 gene by NFATc2.

scientific article

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst

scientific article

Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo

scientific article published on October 2008

Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

scientific article

Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.

scientific article published on 18 September 2008

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

scientific article published on 01 May 2021

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

scientific article

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.

scientific article

Self-aggregation characteristics of recombinantly expressed human elastin polypeptides

scientific article published in November 2001

Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

scientific article published in Nature Communications

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart.

scientific article published in January 2018

Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer

scientific article published on 01 November 2018

Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer

scientific article published on 17 February 2020

Single-cell mRNA profiling identifies progenitor subclasses in neurospheres.

scientific article published on 10 September 2012

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

scientific article published on 30 September 2021

Single-cell multimodal profiling reveals cellular epigenetic heterogeneity.

scientific article published on 15 August 2016

Single-cell transcriptional analysis to uncover regulatory circuits driving cell fate decisions in early mouse development

scientific article published on 20 November 2014

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes.

scientific article

Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

scientific article published on 11 March 2019

Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro.

scientific article published on 26 July 2004

The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

scientific article published on 11 March 2014

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

scientific journal article

The importance of study design for detecting differentially abundant features in high-throughput experiments.

scientific article

The maturing of the human embryonic stem cell transcriptome profile.

scientific article

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation

scientific article published on 7 December 2017

The unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebrates.

scientific article published in May 2001

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

scientific article published on 23 January 2020

Tumor-derived circulating endothelial cell clusters in colorectal cancer

scientific article

Unraveling the human embryonic stem cell phosphoproteome

scientific article published in August 2009

List of works by Paul Robson

A core Klf circuitry regulates self-renewal of embryonic stem cells

A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.

A path to translation: How 3D patient tumor avatars enable next generation precision oncology

Author Correction: Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

BCL-XL mediates the strong selective advantage of a 20q11.21 amplification commonly found in human embryonic stem cell cultures.

BMP signalling regulates the pre-implantation development of extra-embryonic cell lineages in the mouse embryo.

Bifurcation analysis of single-cell gene expression data reveals epigenetic landscape

Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

Cellular taxonomy and spatial organization of the murine ventral posterior hypothalamus

Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal

Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells

Conversion of Sox17 into a pluripotency reprogramming factor by reengineering its association with Oct4 on DNA

Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

DNA-dependent Oct4-Sox2 interaction and diffusion properties characteristic of the pluripotent cell state revealed by fluorescence spectroscopy.

Deciphering developmental processes from single-cell transcriptomes

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.

Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through Fgf4/Fgfr2 signalling in preimplantation mouse embryos

Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells

Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2.

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis.

High throughput gene expression analysis identifies reliable expression markers of human corneal endothelial cells.

Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

Identification and characterization of a serpin with differential expression during the life cycle of the sea lamprey

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.

Inner cell mass-specific expression of a cell adhesion molecule (PECAM-1/CD31) in the mouse blastocyst

Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancer

Mapping systemic lupus erythematosus heterogeneity at the single-cell level

Mapping the Global Chromatin Connectivity Network for Sox2 Function in Neural Stem Cell Maintenance ⬇️

Oct4 and Sox2 directly regulate expression of another pluripotency transcription factor, Zfp206, in embryonic stem cells

Oct4 cell-autonomously promotes primitive endoderm development in the mouse blastocyst

Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.

Osteogenic differentiation within intact human embryoid bodies result in a marked increase in osteocalcin secretion after 12 days of in vitro culture, and formation of morphologically distinct nodule-like structures.

Partial clone of the gene for AS protein of the lampreyPetromyzon marinus, a member of the albumin supergene family whose expression is restricted to the larval and metamorphic phases of the life cycle ⬇️

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

Regulation of the murine Nfatc1 gene by NFATc2.

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst

Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo

Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.

Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells.

Self-aggregation characteristics of recombinantly expressed human elastin polypeptides

Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart.

Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One-Carbon, Polyamine, and Purine Synthesis in Breast Cancer

Single-cell analyses reveal increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer

Single-cell mRNA profiling identifies progenitor subclasses in neurospheres.

Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response

Single-cell multimodal profiling reveals cellular epigenetic heterogeneity.

Single-cell transcriptional analysis to uncover regulatory circuits driving cell fate decisions in early mouse development

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes.

Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

Strategies for directing the differentiation of stem cells into the osteogenic lineage in vitro.

The Brm-HDAC3-Erm repressor complex suppresses dedifferentiation in Drosophila type II neuroblast lineages

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

The importance of study design for detecting differentially abundant features in high-throughput experiments.

The maturing of the human embryonic stem cell transcriptome profile.

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation

The unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebrates.

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Tumor-derived circulating endothelial cell clusters in colorectal cancer

Unraveling the human embryonic stem cell phosphoproteome