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List of works by Iñaki Comas

A novel strategy based on genomics and specific PCR reveals how a multidrug-resistant Mycobacterium tuberculosis strain became prevalent in Equatorial Guinea 15 years after its emergence.

scientific article published on 13 October 2016

A role for systems epidemiology in tuberculosis research

scientific article

A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis

scientific article published on 28 December 2017

An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis

scientific article published on 24 November 2021

Antibiotic resistance prediction for Mycobacterium tuberculosis from genome sequence data with Mykrobe

scientific article published on 02 December 2019

Application of machine learning techniques to tuberculosis drug resistance analysis

scholarly article by Samaneh Kouchaki et al published 21 November 2018 in Bioinformatics

Author Correction: Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase

scientific article published on 21 February 2020

Characterization of Polymorphisms Associated with Multidrug-Resistant Tuberculosis by Whole Genomic Sequencing: A Preliminary Report from Mexico

scientific article published on 23 December 2019

China's tuberculosis epidemic stems from historical expansion of four strains of Mycobacterium tuberculosis

article

Comment on: characterization of the embB gene in Mycobacterium tuberculosis isolates from Barcelona and rapid detection of main mutations related to ethambutol resistance using a low-density DNA array

scientific article published on 20 April 2014

Complete Analysis of the Epidemiological Scenario around a SARS-CoV-2 Reinfection: Previous Infection Events and Subsequent Transmission

scientific article published on 08 September 2021

Contaminant DNA in bacterial sequencing experiments is a major source of false genetic variability

scientific article published on 02 March 2020

Cryptic Resistance Mutations Associated With Misdiagnoses of Multidrug-Resistant Tuberculosis

scientific article published on 01 June 2019

Development and application of affordable SNP typing approaches to genotype Mycobacterium tuberculosis complex strains in low and high burden countries

scientific article published on 25 October 2019

Draft Genome Sequence of Mycobacterium brumae ATCC 51384.

scientific article published on 28 April 2016

Draft Genome Sequences of Mycobacterium setense Type Strain DSM-45070 and the Nonpathogenic Strain Manresensis, Isolated from the Bank of the Cardener River in Manresa, Catalonia, Spain

scientific article

Emergence and spread of a SARS-CoV-2 variant through Europe in the summer of 2020

scientific article published on 27 November 2020

Evaluation of customised lineage-specific sets of MIRU-VNTR loci for genotyping Mycobacterium tuberculosis complex isolates in Ghana

scientific article

Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure.

scientific article published on 28 February 2013

Evolution of snake venom disintegrins by positive Darwinian selection

scientific article

Evolutionary Dissection of the Dot/Icm System Based on Comparative Genomics of 58 Legionella Species

scientific article published on 01 September 2019

Evolutionary and Phenotypic Characterization of Two Spike Mutations in European Lineage 20E of SARS-CoV-2

scientific article published on 16 November 2021

Evolutionary trajectories of beta-lactamase CTX-M-1 cluster enzymes: predicting antibiotic resistance

scientific article

Fast and low-cost decentralized surveillance of transmission of tuberculosis based on strain-specific PCRs tailored from whole genome sequencing data: a pilot study.

scientific article

From phylogenetics to phylogenomics: the evolutionary relationships of insect endosymbiotic gamma-Proteobacteria as a test case.

scientific article published in February 2007

Gene evolutionary trajectories in <i>Mycobacterium tuberculosis</i> reveal temporal signs of selection

scientific article published on 22 April 2022

Gene expression models based on a reference laboratory strain are bad predictors of Mycobacterium tuberculosis complex transcriptional diversity

article

Gene expression models based on a reference laboratory strain are poor predictors of Mycobacterium tuberculosis complex transcriptional diversity.

scientific article published on 28 February 2018

Genetic diversity within Mycobacterium tuberculosis complex impacts on the accuracy of genotypic pyrazinamide drug-susceptibility assay

scientific article

Genome-wide Mapping of Transcriptional Start Sites Defines an Extensive Leaderless Transcriptome in Mycobacterium tuberculosis

scholarly article by Teresa Cortes et al published January 2014 in Cell Reports

Genome-wide mapping of transcriptional start sites defines an extensive leaderless transcriptome in Mycobacterium tuberculosis

scientific article

Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex

scientific article published on 05 September 2019

Genomic Analysis of Bacterial Outbreaks

Genomic Epidemiology of Tuberculosis

scientific article published in January 2017

Genomic analyses of Mycobacterium tuberculosis from human lung resections reveal a high frequency of polyclonal infections

scientific article published on 11 May 2021

Genomic determinants of speciation and spread of the Mycobacterium tuberculosis complex

scientific article published on 12 June 2019

Genomic determinants of sympatric speciation of theMycobacterium tuberculosiscomplex across evolutionary timescales

Genotyping of genetically monomorphic bacteria: DNA sequencing in Mycobacterium tuberculosis highlights the limitations of current methodologies.

scientific article

Glucocorticoid-dependent transcription in skin requires epidermal expression of the glucocorticoid receptor and is modulated by the mineralocorticoid receptor

scientific article published on 03 November 2020

High-resolution mapping of tuberculosis transmission: Whole genome sequencing and phylogenetic modelling of a cohort from Valencia Region, Spain

scientific article published on 31 October 2019

Horizontal gene transfer in the molecular evolution of mannose PTS transporters.

scientific article published in August 2005

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved

scientific article

Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages

scientific article

In-Depth Characterization and Functional Analysis of Clonal Variants in a Mycobacterium tuberculosis Strain Prone to Microevolution.

scientific article

Influence of Gut Microbiota on Progression to Tuberculosis Generated by High Fat Diet-Induced Obesity in C3HeB/FeJ Mice

scientific article published on 18 October 2019

Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase

scientific article published in Scientific Reports

Large genomics datasets shed light on the evolution of the Mycobacterium tuberculosis complex

scientific article published on 26 February 2019

Legionella effectors reflect strength in diversity

scientific article published in January 2016

Long-range transcriptional control of an operon necessary for virulence-critical ESX-1 secretion in Mycobacterium tuberculosis

scientific article

Mapping of genotype-phenotype diversity among clinical isolates of mycobacterium tuberculosis by sequence-based transcriptional profiling

scientific article published on January 2013

Molecular epidemiology studies on the immigrant population in Spain

scientific article published on November 2014

Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia.

scientific article published on March 2013

Mycobacterium tuberculosis Acquires Limited Genetic Diversity in Prolonged Infections, Reactivations and Transmissions Involving Multiple Hosts

scientific article published in January 2017

Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1β production

scientific article published on 23 April 2020

Mycobacterium tuberculosis clinical isolates carry mutational signatures of host immune environments

scientific article published on 29 May 2020

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages

scientific article published on 31 October 2016

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

scientific article

Next generation sequencing for the diagnostics and epidemiology of tuberculosis

scientific article published on July 2016

Novel Mycobacterium tuberculosis complex isolate from a wild chimpanzee

scientific article published on June 2013

Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans

scientific article (publication date: October 2013)

Overlapping of Independent SARS-CoV-2 Nosocomial Transmissions in a Complex Outbreak

scientific article published on 04 August 2021

Persistent Infection by a Mycobacterium tuberculosis Strain That Was Theorized To Have Advantageous Properties, as It Was Responsible for a Massive Outbreak

scientific article

Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis.

scientific article

Phylogenetic signal and functional categories in Proteobacteria genomes

scientific article

Population Genomics of Mycobacterium tuberculosis in Ethiopia Contradicts the Virgin Soil Hypothesis for Human Tuberculosis in Sub-Saharan Africa.

scientific article

Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis

scientific article (publication date: 23 October 2014)

Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing

scientific article published on 26 September 2018

Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection

publication published on 01 September 2021

Quantifying nonvertical inheritance in the evolution of Legionella pneumophila.

scientific article published on 20 October 2010

Recombination drives genome evolution in outbreak-related Legionella pneumophila isolates.

scientific article

Recurrences of multidrug-resistant tuberculosis: strains involved, within-host diversity, and fine-tuned allocation of reinfections

scientific article published on 07 January 2021

SARS-CoV-2 Outbreak on a Spanish Mink Farm: Epidemiological, Molecular, and Pathological Studies

scientific article published on 01 January 2021

Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

scientific article published on 17 February 2020

Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis

scientific article

Simplified Model to Survey Tuberculosis Transmission in Countries Without Systematic Molecular Epidemiology Programs

article

Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese

scientific article published on 15 June 2015

Specificity and mutagenesis bias of the mycobacterial alternative mismatch repair analyzed by mutation accumulation studies

scientific article published on 12 February 2020

SplitStrains, a tool to identify and separate mixed <i>Mycobacterium tuberculosis</i> infections from WGS data

scientific article published on 01 June 2021

Subtle genotypic changes can be observed soon after diagnosis in Mycobacterium tuberculosis infection

scientific article published on 16 May 2016

Systematic Genomic and Clinical Analysis of Severe Acute Respiratory Syndrome Coronavirus 2 Reinfections and Recurrences Involving the Same Strain

scientific article published on 29 November 2021

TB Transmission: Closing the Gaps

scientific article published on 30 July 2018

The Evolution of Antibiotic Resistance

scholarly article published 2011

The Evolutionary Origin of Xanthomonadales Genomes and the Nature of the Horizontal Gene Transfer Process

article

The Future of TB Resistance Diagnosis: The Essentials on Whole Genome Sequencing and Rapid Testing Methods

scientific article published on 20 February 2019

The Sputum Microbiome in Pulmonary Tuberculosis and Its Association With Disease Manifestations: A Cross-Sectional Study

scientific article published on 20 August 2021

The Troika Host-Pathogen-Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes.

scientific article published in January 2017

The effect size of type 2 diabetes mellitus on tuberculosis drug resistance and adverse treatment outcomes.

scientific article published on 24 January 2017

The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

scientific article published on 30 September 2021

The genome of Mycobacterium africanum West African 2 reveals a lineage-specific locus and genome erosion common to the M. tuberculosis complex

scientific article published on 28 February 2012

The past and future of tuberculosis research

scientific article

Towards next generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics

Towards next-generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics

scientific article published on 01 February 2020

Tuberculosis in Liberia: high multidrug-resistance burden, transmission and diversity modelled by multiple importation events

scientific article published on 01 January 2020

Two new rapid SNP-typing methods for classifying mycobacterium tuberculosis complex into the main phylogenetic lineages

scientific article (publication date: 2012)

Ultrafast Assessment of the Presence of a High-Risk Mycobacterium tuberculosis Strain in a Population

scientific article published on 30 December 2015

Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context.

scientific article

Urgent Implementation in a Hospital Setting of a Strategy To Rule Out Secondary Cases Caused by Imported Extensively Drug-Resistant Mycobacterium tuberculosis Strains at Diagnosis.

scientific article published on 28 September 2016

Use of next generation sequencing technologies for the diagnosis and epidemiology of infectious diseases

scientific article published on 01 January 2020

Validating viral quasispecies with digital organisms: a re-examination of the critical mutation rate

scientific article

Whole genome sequencing analysis of intrapatient microevolution in Mycobacterium tuberculosis: potential impact on the inference of tuberculosis transmission.

scientific article

Whole genome sequencing of Mycobacterium tuberculosis: current standards and open issues

scientific article published on 01 September 2019

Whole genome sequencing-based analysis of tuberculosis (TB) in migrants: rapid tools for cross-border surveillance and to distinguish between recent transmission in the host country and new importations

article

Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico

scientific article published on 05 June 2019

Whole-genome sequence analysis of the Mycobacterium avium complex and proposal of the transfer of Mycobacterium yongonense to Mycobacterium intracellulare subsp. yongonense subsp. nov.

scientific article published on 23 April 2018

Whole-genome sequencing of rifampicin-resistant Mycobacterium tuberculosis strains identifies compensatory mutations in RNA polymerase genes.

scientific article published on 18 December 2011

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