List of works - Takashi Saito

14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer's Disease Mouse Models

scientific article published in 2022

A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity

scientific article published on 28 February 2002

A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase.

scientific article published on December 2006

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

scientific article published on 05 November 2019

APP mouse models for Alzheimer's disease preclinical studies

scientific article published on August 2017

Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease

scientific article published on 01 April 2019

Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism

scientific article

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

scientific article published on 17 May 2019

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

scientific article published on 20 June 2019

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease

scientific article published on 20 March 2019

An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease

scientific article published on 01 June 2019

An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody

scientific article published on 3 April 2017

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

scientific article published on 30 August 2019

AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation

scientific article published on 16 May 2019

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration

scientific article published on 01 July 2019

Aβ secretion and plaque formation depend on autophagy

scientific article

Biology of splicing in Alzheimer's disease research

scientific article published on 17 October 2019

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.

scientific article published on 14 October 2015

Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form

scientific article

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.

scientific article published on September 2016

Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease

scientific article published on 04 August 2021

Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase

scientific article published on 05 July 2012

Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.

scientific article published in March 2018

Cognitive deficits in single App knock-in mouse models

scientific article published on July 2016

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

scientific article published on 19 December 2017

Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease

scientific article published on 12 July 2018

Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice

scientific article published in PLoS ONE

Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model

scientific article published in 2024

Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.

scientific article

Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm

scientific article published on 3 January 2018

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology.

scientific article published on 4 May 2018

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.

scientific article

Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates

scientific article

Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model.

scientific article

Implication of GnT-V in cancer metastasis: a glycomic approach for identification of a target protein and its unique function as an angiogenic cofactor.

scientific article

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules

scientific article published on 28 August 2019

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours

scientific article published on 24 September 2019

Istradefylline reduces memory deficits in aging mice with amyloid pathology

scientific article published on 31 October 2017

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models

scientific article published in October 2015

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

scientific article published on 8 January 2018

Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice

scientific article published on 12 May 2021

Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease

scientific article published on 05 September 2019

Neuroinflammation in mouse models of Alzheimer's disease.

scientific article published on 23 September 2018

New mouse model of Alzheimer's

scientific article published on 22 May 2014

Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease

scientific article published on 01 July 2018

PLD3 gene and processing of APP.

scientific article published in January 2017

Potent amyloidogenicity and pathogenicity of Aβ43.

scientific article published on 3 July 2011

Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology

scientific article published on 03 December 2020

Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse

scientific article published on 01 January 2019

Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer's disease

scientific article published on 5 September 2017

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

scientific article published on 23 April 2019

ScaleS: an optical clearing palette for biological imaging.

scientific article published on 14 September 2015

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice.

scientific article published on 19 April 2018

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

scientific article published on January 2013

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition

scientific article published on 17 November 2017

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice

scientific article published in PLoS ONE

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.

scientific article published on 3 March 2018

The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology

article

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

scientific article published on 23 August 2017

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease

scientific article published on 13 November 2020

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

scientific article published on 13 December 2018

Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

scientific article published on 27 April 2020

[Presymptomatic diagnosis, prevention and therapy]

scientific article published on 01 October 2005

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

scientific article published on 01 January 2020

List of works by Takashi Saito

14-3-3θ Does Not Protect against Behavioral or Pathological Deficits in Alzheimer's Disease Mouse Models

A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity

A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase.

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain

APP mouse models for Alzheimer's disease preclinical studies

Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease

Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease

An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease

An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain

AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration

Aβ secretion and plaque formation depend on autophagy

Biology of splicing in Alzheimer's disease research

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.

Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.

Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease

Cell surface expression of the major amyloid-β peptide (Aβ)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase

Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.

Cognitive deficits in single App knock-in mouse models

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease

Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice

Disturbance in the protein landscape of cochlear perilymph in an Alzheimer’s disease mouse model

Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease.

Endoplasmic reticulum stress responses in mouse models of Alzheimer disease: overexpression paradigm versus knock-in paradigm

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology.

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease.

Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates

Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model.

Implication of GnT-V in cancer metastasis: a glycomic approach for identification of a target protein and its unique function as an angiogenic cofactor.

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours

Istradefylline reduces memory deficits in aging mice with amyloid pathology

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice

Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease

Neuroinflammation in mouse models of Alzheimer's disease.

New mouse model of Alzheimer's

Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease

PLD3 gene and processing of APP.

Potent amyloidogenicity and pathogenicity of Aβ43.

Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology

Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse

Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer's disease

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

ScaleS: an optical clearing palette for biological imaging.

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice.

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.

The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone

Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues

[Presymptomatic diagnosis, prevention and therapy]

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade