List of works - Michael A Rogawski

"Jasper's Basic Mechanisms of the Epilepsies" Workshop

scientific article

1,10-Diaminodecane and 1,12-diaminododecane block NMDA receptor currents by an open channel mechanism

scientific article published on December 7, 1992

11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis.

scientific article

17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.

scientific article

2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects

scientific article published on May 2016

Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304

scientific article

Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats

scientific article published on 11 September 2020

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease

scientific article published on 3 June 2015

Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBQX in maximal electroshock and chemoconvulsant seizure models ⬇️

scientific article published on 01 July 1993

Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.

scientific article published on 24 February 2004

Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose

scientific article published on 17 May 2010

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

scientific article

Anxiolytic activity of progesterone in progesterone receptor knockout mice.

scientific article published in January 2005

Astrocytes get in the act in epilepsy

scientific article published in September 2005

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

scientific article published on 01 December 2019

Brivaracetam: a rational drug discovery success story

scientific article

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine

scientific article

Charybdotoxin, dendrotoxin and mast cell degranulating peptide block the voltage-activated K+ current of fibroblast cells stably transfected with NGK1 (Kv1.2) K+ channel complementary DNA

scientific article published on October 1, 1992

Clinical spectrum of succinic semialdehyde dehydrogenase deficiency ⬇️

scientific article published on May 13, 2003

Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.

scientific article

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures

scientific article published on 14 April 2015

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

scientific article published on 15 December 2017

Compromised function in the Na(v)1.2 Dravet syndrome mutation R1312T.

scientific article published on 4 June 2012

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome

scientific article published on 16 September 2017

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.

scientific article published on 6 April 2018

Disclosure of clinical trial results when product development is abandoned.

scientific article published on September 2011

Diverse mechanisms of antiepileptic drugs in the development pipeline

scientific article

Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice

scientific article (publication date: March 1992)

Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice

scientific article published in June 2003

Efficacy of the ketogenic diet in the 6-Hz seizure test.

scientific article published on 6 December 2007

Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy

scientific article published on 14 June 2006

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures

scientific article

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

scientific article

Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala.

scientific article

Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania

scientific article

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses ⬇️

scientific article published on January 1, 1993

Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model

scientific article

High concentrations of neutral amino acids activate NMDA receptor currents in rat hippocampal neurons

scientific article published on July 6, 1992

IgG isolated from LP-BM5 infected mouse brain activates ionotropic glutamate receptors

scientific article published in December 2001

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.

scientific article published on 17 February 2018

Issues related to development of new antiseizure treatments

scientific article published on August 2013

Molecular targets versus models for new antiepileptic drug discovery

scientific article

Muscarinic antagonists attenuate dizocilpine-induced hypermotility in mice ⬇️

scientific article published on 01 January 1992

Neuroactive steroids for the treatment of status epilepticus

scientific article published on September 2013

Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period

scientific article published on January 2009

Neurosteroids as endogenous regulators of seizure susceptibility and use in the treatment of epilepsy.

scientific article

New antiepileptic drugs: from serendipity to rational discovery

scientific article published on January 1, 1992

Obituary

scientific article published in September 2009

Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome

scientific article

Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam

scientific article published on 29 April 2021

Phencyclidine block of calcium current in isolated guinea-pig hippocampal neurones ⬇️

scientific article published on October 1, 1992

Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy

scientific article published in March 2003

Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA.

scientific article

Propofol hemisuccinate suppresses cortical spreading depression

scientific article

Role of neurosteroids in the anticonvulsant activity of midazolam

scientific article

Seizure protection by intrapulmonary delivery of propofol hemisuccinate

scientific article

Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models.

scientific article published on 3 July 2006

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation

scientific article

The NMDA receptor, NMDA antagonists and epilepsy therapy. A status report

scientific article published on September 1, 1992

The Pheromone Androstenol (5 -Androst-16-en-3 -ol) Is a Neurosteroid Positive Modulator of GABAA Receptors

scientific article (publication date: 2 February 2006)

The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid

scientific article published on 26 March 2007

The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.

scientific article published in July 2004

The neuropharmacology of the ketogenic diet

scientific article

The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant

scientific article

Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 (GluR5) kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons.

scientific article published on 5 May 2009

Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist

scientific article published in June 2004

List of works by Michael A Rogawski

"Jasper's Basic Mechanisms of the Epilepsies" Workshop

1,10-Diaminodecane and 1,12-diaminododecane block NMDA receptor currents by an open channel mechanism

11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis.

17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities.

2014 Epilepsy Benchmarks Area III: Improve Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects

Adjunctive perampanel for refractory partial-onset seizures: randomized phase III study 304

Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats

Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease

Anticonvulsant activity of AMPA/kainate antagonists: comparison of GYKI 52466 and NBQX in maximal electroshock and chemoconvulsant seizure models ⬇️

Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.

Anticonvulsant and proconvulsant actions of 2-deoxy-D-glucose

Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms

Anxiolytic activity of progesterone in progesterone receptor knockout mice.

Astrocytes get in the act in epilepsy

Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction

Brivaracetam: a rational drug discovery success story

Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine

Charybdotoxin, dendrotoxin and mast cell degranulating peptide block the voltage-activated K+ current of fibroblast cells stably transfected with NGK1 (Kv1.2) K+ channel complementary DNA

Clinical spectrum of succinic semialdehyde dehydrogenase deficiency ⬇️

Clustered burst firing in FMR1 premutation hippocampal neurons: amelioration with allopregnanolone.

Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

Compromised function in the Na(v)1.2 Dravet syndrome mutation R1312T.

Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome

Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.

Disclosure of clinical trial results when product development is abandoned.

Diverse mechanisms of antiepileptic drugs in the development pipeline

Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice

Effects of neurosteroids on epileptiform activity induced by picrotoxin and 4-aminopyridine in the rat hippocampal slice

Efficacy of the ketogenic diet in the 6-Hz seizure test.

Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy

Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures

Evaluation of the neuroactive steroid ganaxolone on social and repetitive behaviors in the BTBR mouse model of autism

Evidence for low GluR2 AMPA receptor subunit expression at synapses in the rat basolateral amygdala.

Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania

GYKI 52466, a 2,3-benzodiazepine, is a highly selective, noncompetitive antagonist of AMPA/kainate receptor responses ⬇️

Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model

High concentrations of neutral amino acids activate NMDA receptor currents in rat hippocampal neurons

IgG isolated from LP-BM5 infected mouse brain activates ionotropic glutamate receptors

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.

Issues related to development of new antiseizure treatments

Molecular targets versus models for new antiepileptic drug discovery

Muscarinic antagonists attenuate dizocilpine-induced hypermotility in mice ⬇️

Neuroactive steroids for the treatment of status epilepticus

Neurosteroids and epileptogenesis in the pilocarpine model: evidence for a relationship between P450scc induction and length of the latent period

Neurosteroids as endogenous regulators of seizure susceptibility and use in the treatment of epilepsy.

New antiepileptic drugs: from serendipity to rational discovery

Obituary

Open-Label Allopregnanolone Treatment of Men with Fragile X-Associated Tremor/Ataxia Syndrome

Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam

Phencyclidine block of calcium current in isolated guinea-pig hippocampal neurones ⬇️

Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy

Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA.

Propofol hemisuccinate suppresses cortical spreading depression

Role of neurosteroids in the anticonvulsant activity of midazolam

Seizure protection by intrapulmonary delivery of propofol hemisuccinate

Termination of epileptiform activity by cooling in rat hippocampal slice epilepsy models.

Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation

The NMDA receptor, NMDA antagonists and epilepsy therapy. A status report

The Pheromone Androstenol (5 -Androst-16-en-3 -ol) Is a Neurosteroid Positive Modulator of GABAA Receptors

The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid

The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.

The neuropharmacology of the ketogenic diet

The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant

Topiramate reduces excitability in the basolateral amygdala by selectively inhibiting GluK1 (GluR5) kainate receptors on interneurons and positively modulating GABAA receptors on principal neurons.

Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist