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List of works by Johannes Grillari

A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging

scientific article

A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cells

scientific article

A signature of 12 microRNAs is robustly associated with growth rate in a variety of CHO cell lines

scientific article published on 15 March 2016

ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis

scientific article published on April 2012

Age-Induced Changes in White, Brite, and Brown Adipose Depots: A Mini-Review.

scientific article

Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries.

scientific article published in December 2002

Alterations in fatty acid utilization and an impaired antioxidant defense mechanism are early events in podocyte injury: a proteomic analysis

scientific article

Analysis of alterations in gene expression after amplification of recombinant genes in CHO cells

scientific article published on April 2001

Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation

scientific article

Annotation of additional evolutionary conserved microRNAs in CHO cells from updated genomic data

scientific article

Antimicrobial photodynamic therapy fighting polymicrobial infections - a journey from in vitro to in vivo

scientific article published on 30 September 2020

Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo.

scientific article published on 18 December 2016

Autophagy deficient melanocytes display a senescence associated secretory phenotype that includes oxidized lipid mediators

scientific article published on 11 October 2016

Biogerontology in Austria

scientific article published on 27 February 2010

Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.

scientific article published on 29 July 2009

CHO microRNA engineering is growing up: recent successes and future challenges

scientific article published on 02 August 2013

Characterization of a novel cell penetrating peptide derived from human Oct4.

scientific article

Chinese hamster genome sequenced from sorted chromosomes

scientific article published in August 2013

Chronic arsenic trioxide exposure leads to enhanced aggressiveness via Met oncogene addiction in cancer cells

scientific article published on 28 March 2016

Circulating microRNA Signatures in Patients With Idiopathic and Postmenopausal Osteoporosis and Fragility Fractures.

scientific article published on 23 August 2016

Circulating microRNAs as novel biomarkers for bone diseases - Complex signatures for multifactorial diseases?

scientific article published on 22 October 2015

Circulating microRNAs in young individuals with long-duration type 1 diabetes in comparison with healthy controls

scientific article published in 2023

Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines

scientific article published on 25 January 2012

Construction of a stability landscape of the CH3 domain of human IgG1 by combining directed evolution with high throughput sequencing

scientific article

Contributions of DNA interstrand cross-links to aging of cells and organisms

scientific article published on 14 December 2007

Corrigendum: Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.

scientific article published on 11 May 2016

Cost-utility analysis of fracture risk assessment using microRNAs compared with standard tools and no monitoring in the Austrian female population

scientific article published on 18 December 2017

Critical Impact of Human Amniotic Membrane Tension on Mitochondrial Function and Cell Viability In Vitro

scientific article published on 15 December 2019

Delineation of the key aspects in the regulation of epithelial monolayer formation

scientific article published on 22 April 2013

Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation.

scientific article

Dynamic mRNA and miRNA profiling of CHO-K1 suspension cell cultures

scientific article published on 5 August 2011

Early embryonic lethality of mice lacking the essential protein SNEV

scientific article

Endogenous microRNA clusters outperform chimeric sequence clusters in Chinese hamster ovary cells

scientific article published on 12 February 2014

Endothelial Cell-derived Extracellular Vesicles Size-dependently Exert Procoagulant Activity Detected by Thromboelastometry

scientific article

Endothelial Extracellular Vesicles-Promises and Challenges

scientific article

Enhanced protein production by microRNA-30 family in CHO cells is mediated by the modulation of the ubiquitin pathway

scientific article published on 6 August 2015

Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element.

scientific article

Erratum: Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles

scientific article published on May 2016

Establishment of a strategy for the rapid generation of a monoclonal antibody against the human protein SNEV (hNMP200) by flow-cytometric cell sorting

scientific article

Exo70, a subunit of the exocyst complex, interacts with SNEV(hPrp19/hPso4) and is involved in pre-mRNA splicing

scientific article published on August 2011

Fluorescence-Based Nanoparticle Tracking Analysis and Flow Cytometry for Characterization of Endothelial Extracellular Vesicle Release

scientific article published on 04 December 2020

From cellular senescence to age-associated diseases: the miRNA connection

scientific article published on 03 December 2012

Generation of human induced pluripotent stem cells from urine samples.

scientific article

Generation of induced pluripotent stem cells from urine

scientific article

GiSAO.db: a database for ageing research

scientific article

Grundlagen der biologischen Alterung

scientific article published on 21 February 2015

HIV-1 induces telomerase activity in monocyte-derived macrophages, possibly safeguarding one of its reservoirs.

scientific article

Haploinsufficiency of senescence evasion factor causes defects of hematopoietic stem cells functions

scientific article

High-glucose--triggered apoptosis in cultured endothelial cells

scientific article published on 01 November 1995

Human cell lines for the production of recombinant proteins: on the horizon.

scientific article published on 18 December 2014

Identification of cultivation-independent markers of human endothelial cell senescence in vitro

scientific article published on 22 March 2007

Identification of evolutionarily conserved genetic regulators of cellular aging

scientific article

Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts

scientific article

Identification of microRNAs specific for high producer CHO cell lines using steady-state cultivation

scientific article

In Search of 'Omics'-Based Biomarkers to Predict Risk of Frailty and Its Consequences in Older Individuals: The FRAILOMIC Initiative.

scientific article published on 23 July 2015

Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA

scientific article

Interaction of U-box E3 ligase SNEV with PSMB4, the beta7 subunit of the 20 S proteasome

scientific article

Interplay between mitochondrial reactive oxygen species, oxidative stress and hypoxic adaptation in facioscapulohumeral muscular dystrophy: Metabolic stress as potential therapeutic target

scientific article published on 29 January 2022

Investigations into cytotoxic effects of the herbal preparation Abnormal Savda Munziq

scientific article published on 12 May 2015

Killer T cells: a promising new tool for adoptive immunotherapy

scientific article published on 01 November 2002

Label-free live cell imaging by Confocal Raman Microscopy identifies CHO host and producer cell lines

scientific article published on 21 July 2016

Laboratory biomarkers and frailty: presentation of the FRAILOMIC initiative

scientific article published on 14 March 2015

Large-scale production and characterization of novel CD4+ cytotoxic T cells with broad tumor specificity for immunotherapy

scientific article

Long-term exposure of immortalized keratinocytes to arsenic induces EMT, impairs differentiation in organotypic skin models and mimics aspects of human skin derangements.

scientific article published on 3 August 2017

Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan.

scientific article published on 30 January 2015

MicroRNA-17-5p: At the Crossroads of Cancer and Aging - A Mini-Review

scientific article

MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes

scientific article published on 01 June 2014

MicroRNA-663 induction upon oxidative stress in cultured human fibroblasts depends on the chronological age of the donor

scientific article published on 25 March 2014

MicroRNAs and toxicology: A love marriage

scientific article published on 13 November 2017

MicroRNAs differentially present in the plasma of HIV elite controllers reduce HIV infection in vitro

scientific article

Microarray profiling of preselected CHO host cell subclones identifies gene expression patterns associated with increased production capacity

scientific article published on 24 August 2015

Molecular and cellular effects of in vitro shockwave treatment on lymphatic endothelial cells

scientific article published on 11 December 2014

Next-generation sequencing of the CHO cell transcriptome

scientific article

Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering

scientific article

Novel human renal proximal tubular cell line for the production of complex proteins.

scientific article published on 16 February 2014

OLR1 scavenger receptor knockdown affects mitotic gene expression but is dispensable for oxidized phospholipid- mediated stress signaling in SZ 95 sebocytes.

scientific article published on 2 November 2017

OncomiR-17-5p: alarm signal in cancer?

scientific article published on 18 July 2017

Oncostatin M is a novel inhibitor of TGF-β1-induced matricellular protein expression.

scientific article

Optimization of a quantitative PCR based method for plasmid copy number determination in human cell lines.

scientific article

Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging

scientific article published on 06 March 2020

Post-translational modification of cellular proteins by ubiquitin and ubiquitin-like molecules: role in cellular senescence and aging.

scientific article published on January 2010

Prediction of transcribed PIWI-interacting RNAs from CHO RNAseq data

scientific article

Proteome profiling in IL-1β and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis

scientific article

SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly

scientific article

SNEV overexpression extends the life span of human endothelial cells

scientific article

SNEV(Prp19/PSO4) deficiency increases PUVA-induced senescence in mouse skin

scientific article published on 14 December 2015

SNEVhPrp19/hPso4 Regulates Adipogenesis of Human Adipose Stromal Cells

scientific article published on 21 December 2016

Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells.

scientific article published on 04 May 2016

Secretion of microvesicular miRNAs in cellular and organismal aging.

scientific article published on 30 December 2012

Serum miRNA Signatures Are Indicative of Skeletal Fractures in Postmenopausal Women With and Without Type 2 Diabetes and Influence Osteogenic and Adipogenic Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells In Vitro.

scientific article published on 27 June 2016

Stable overexpression of miR-17 enhances recombinant protein production of CHO cells

scientific article published on 8 February 2014

Subtractive hybridization of mRNA from early passage and senescent endothelial cells

scientific article

The CHO miRNA Transcriptome

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy.

scientific article published on 23 November 2017

The role of microRNAs in cellular senescence and age-related conditions of cartilage and bone.

scientific article

Transcriptomic changes in CHO cells after adaptation to suspension growth in protein-free medium analysed by a species-specific microarray

scientific article published on 13 March 2017

UVB-Induced Senescence of Human Dermal Fibroblasts Involves Impairment of Proteasome and Enhanced Autophagic Activity.

scientific article

Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span

scientific article

Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing

scientific article

Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death

scientific article

Urine as a source of stem cells.

scientific article published on January 2013

Urine is a novel source of autologous mesenchymal stem cells for patients with epidermolysis bullosa.

scientific article published on 10 December 2015

Utilization and evaluation of CHO-specific sequence databases for mass spectrometry based proteomics

scientific article published on 2 March 2012

Vesicular Galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles

scientific article published on 9 January 2016

WNT signaling suppression in the senescent human thymus.

scientific article

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

scientific article

miR-17-92 cluster: ups and downs in cancer and aging

scientific article

miRNA-21 deficiency impairs alveolar socket healing in mice

scientific article published on 12 May 2020

miRNAs – pathway engineering of CHO cell factories that avoids translational burdening ⬇️

scientific article published on June 4, 2012

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