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List of works by Graham Dellaire

A Bayesian network model of proteins' association with promyelocytic leukemia (PML) nuclear bodies

scientific article published in April 2010

A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

scientific article published on 01 December 2018

A SUF Fe-S cluster biogenesis system in the mitochondrion-related organelles of the anaerobic protist Pygsuia

scientific article published on 22 May 2014

A marker-free co-selection strategy for high efficiency homology-driven and NHEJ-based gene editing in human cells

article

A mechanism for the suppression of homologous recombination in G1 cells

scientific article published on 9 December 2015

A requirement for polymerized actin in DNA double-strand break repair

scientific article

A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy

scientific article

Abstract 3404: Identifying genes involved in retinoic-acid-mediated breast tumor progression by total-genome-knockdown screen

article

Abstract 3583: Thymocyte selection-associated HMG box protein (TOX) induces genomic instability in T-cell acute lymphoblastic leukemia

Abstract 3865: Thymocyte selection-associated HMG box protein (TOX) induces genomic instability in T-cell acute lymphoblastic leukemia

Abstract 3916: PML nuclear bodies are juxtaposed to DNA-DSBs following IR-induced DNA damage

Abstract 4258:In vivoanti-leukemia activity of novel C-ring modified prodigiosenes in a zebrafish xenograft model

Abstract A21: MiR-106a and miR-106b affect growth and metastasis of lung adenocarcinoma

Abstract B12: A large-scale transgenic screen in zebrafish identifies TOX as a novel oncogene in T-cell acute lymphoblastic leukemia

An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin

scientific article

An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis

scientific article published on 02 April 2019

Angels and Devils: Dilemmas in Dual-Use Biotechnology

scientific article published on 10 August 2018

Animal Models of Metastasis

Application of quantum dots as probes for correlative fluorescence, conventional, and energy-filtered transmission electron microscopy

scientific article published on January 2004

Back to Basics: Application of the Principles of Bioethics to Heritable Genome Interventions

scientific article published on 10 June 2020

Beyond repair foci: subnuclear domains and the cellular response to DNA damage

scientific article published on 11 June 2007

Bitter taste receptors are expressed in human epithelial ovarian and prostate cancers cells and noscapine stimulation impacts cell survival

article

Breast Cancer Genomics

CRISPR/Cas9 Gene Editing: From Basic Mechanisms To Improved Strategies For Enhanced Genome Engineering In Vivo

scientific article published on 21 November 2017

Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif

scientific article

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

scientific article

Chromatin contributes to structural integrity of promyelocytic leukemia bodies through a SUMO-1-independent mechanism

scientific article published on 12 December 2003

Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response

scientific article

Correlative light and electron spectroscopic imaging of chromatin in situ

scientific article published in January 2004

Coupling of Homologous Recombination and the Checkpoint by ATR.

scientific article published on 28 December 2016

DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer

scientific article published on 19 June 2018

Direct evidence that transgene integration is random in murine cells, implying that naturally occurring double-strand breaks may be distributed similarly within the genome

scientific article

Dopamine receptor-interacting protein 78 acts as a molecular chaperone for CCR5 chemokine receptor signaling complex organization.

scientific article

Ectopic Gene Targeting Exhibits a Bimodal Distribution of Integration in Murine Cells, Indicating that Both Intraand Interchromosomal Sites Are Accessible to the Targeting Vector ⬇️

scientific article published on September 1, 1997

Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia

scientific article published on 31 October 2017

ErbB2-dependent downregulation of a pro-apoptotic protein Perp is required for oncogenic transformation of breast epithelial cells.

scientific article

Estrogen receptor alpha (ESR1)-signaling regulates the expression of the taxane-response biomarker PRP4K.

scientific article published on 19 December 2015

Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA BreaksIn vivo

Evidence that extrachromosomal double-strand break repair can be coupled to the repair of chromosomal double-strand breaks in mammalian cells

Expression patterns and post-translational modifications associated with mammalian histone H3 variants

scientific article

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia

scientific article

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.

scientific article published on 12 April 2018

Genetic Disease

Genetic Disease

Genomics and Epigenetics of Malignant Mesothelioma

scientific article published on 27 July 2018

Heterochromatin and the DNA damage response: the need to relax

scientific article published on February 2011

High resolution imaging of changes in the structure and spatial organization of chromatin, gamma-H2A.X and the MRN complex within etoposide-induced DNA repair foci

scientific article published on 14 November 2009

Historical Perspective and Current Challenges of Cancer Genomics

article

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

scientific article

In situ imaging and isolation of proteins using dsDNA oligonucleotides

scientific article

Inhibition of neddylation induces mitotic defects and alters MKLP1 accumulation at the midbody during cytokinesis

scientific article published on 05 May 2019

Investigations regarding the utility of prodigiosenes to treat leukemia

scientific article

KAP1 depletion increases PML nuclear body number in concert with ultrastructural changes in chromatin.

scientific article

Leukaemia xenotransplantation in zebrafish - chemotherapy response assay in vivo

scientific article published on 22 April 2011

Lipid-associated PML structures assemble nuclear lipid droplets containing CCTα and Lipin1

scientific article published on 27 May 2020

Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking

scientific article published on 11 September 2017

Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes

scientific article

Marker-free coselection for CRISPR-driven genome editing in human cells

scientific article published on 17 April 2017

Material properties of disulfide-crosslinked hyaluronic acid hydrogels influence prostate cancer cell growth and metabolism

scientific article published on 05 October 2020

Microbial eukaryotes have adapted to hypoxia by horizontal acquisitions of a gene involved in rhodoquinone biosynthesis

scientific article published on 26 April 2018

Mitotic accumulations of PML protein contribute to the re-establishment of PML nuclear bodies in G1.

scientific article published on 21 February 2006

Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models

scientific article published in January 2016

Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres

scientific article published on 30 March 2017

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes

scientific article published on 01 November 2019

Natural Killer T-cell Immunotherapy in Combination with Chemotherapy-Induced Immunogenic Cell Death Targets Metastatic Breast Cancer

scientific article published on 20 October 2017

Novel RNA and DNA strand exchange activity of the PALB2 DNA binding domain and its critical role for DNA repair in cells

scientific article published on 29 April 2019

Nuclear Domains

article published in 2011

Nuclear Domains and DNA Repair

Nuclear Subdomains and Cancer

Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing

scientific article published on October 2015

Nuclear position dictates DNA repair pathway choice

scientific article

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair

scientific article

Organization of chromatin in the interphase mammalian cell

scientific article

P2.01-024 Expression of miR-106 Paralogs Improves Prognostic Value of Mesenchymal Signatures but Only miR-106b Promotes Invasiveness

PML bodies: a meeting place for genomic loci?

scientific article

PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination

scientific article published on 31 October 2019

PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4

scientific article published on 23 March 2017

PML nuclear bodies: dynamic sensors of DNA damage and cellular stress

scientific article

PRP4K is a HER2-regulated modifier of taxane sensitivity

scientific article

Plant flavonoids in cancer chemoprevention: role in genome stability

scientific article published on 28 November 2016

Precision genome editing in the CRISPR era.

scientific article published on 29 September 2016

Preclinical Animal Models for Cancer Genomics

Projected Barzilai-Borwein Method with Infeasible Iterates for Nonnegative Least-Squares Image Deblurring

scholarly article published May 2014

Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.

scientific article

Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response

scientific article published on 9 November 2011

Reading, writing, and repair: the role of ubiquitin and the ubiquitin-like proteins in DNA damage signaling and repair

scientific article published on April 2013

Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?

scientific article published on 11 October 2020

Regulation of stress-inducible phosphoprotein 1 nuclear retention by protein inhibitor of activated STAT PIAS1.

scientific article

Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.

scientific article

Shigella infection interferes with SUMOylation and increases PML-NB number

scientific article published on 7 April 2015

Size, position and dynamic behavior of PML nuclear bodies following cell stress as a paradigm for supramolecular trafficking and assembly

scientific article published on 16 September 2003

Sorting the nuclear proteome

scientific article published on July 2011

Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking

scientific article

Synthesis and biological evaluation of prodigiosene conjugates of porphyrin, estrone and 4-hydroxytamoxifen

scientific article published on 31 July 2013

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

scientific article published on 3 October 2017

The DNA repair function of CUX1 contributes to radioresistance

scientific article published on 28 January 2017

The Nuclear Oncogene SET Controls DNA Repair by KAP1 and HP1 Retention to Chromatin

The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair

scientific article

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

scientific article published in March 2018

The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain.

scientific article

The Zebrafish Xenograft Platform-A Novel Tool for Modeling KSHV-Associated Diseases

scientific article published on 20 December 2019

The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool

scientific article published on January 2016

The number of PML nuclear bodies increases in early S phase by a fission mechanism

scientific article published on 21 February 2006

The translation initiation factor 3 subunit eIF3K interacts with PML and associates with PML nuclear bodies

scientific article published on 11 September 2013

Transcriptional regulation is affected by subnuclear targeting of reporter plasmids to PML nuclear bodies

scientific article published on 11 September 2006

Translational Activation of HIF1α by YB-1 Promotes Sarcoma Metastasis

scientific article published on May 2015

Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase

scientific article

Zebrafish xenografts as a tool for in vivo studies on human cancer.

scientific article published on August 2012

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