List of works - Karen Vanhoorelbeke

A Reliable von Willebrand factor: ristocetin cofactor enzyme-linked immunosorbent assay to differentiate between type 1 and type 2 von Willebrand disease

scientific article

ADAMTS-13 glycans and conformation-dependent activity.

scientific article

ADAMTS-13 plasma level determination uncovers antigen absence in acquired thrombotic thrombocytopenic purpura and ethnic differences

scientific article

ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw-Schulman Syndrome

article

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

scientific article

ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies

scientific article

ADAMTS13 deficiency in mice does not affect adipose tissue development

scientific article published on 24 March 2015

ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis

scientific article published on 8 September 2016

ADAMTS13 in health and disease

scientific article

ADAMTS13's tail tale

scientific article published on 01 May 2009

ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice.

scientific article

Acquired von Willebrand syndrome in patients on long-term left ventricular assist device support: Results of a Belgian center

scientific article published on 21 October 2019

Activation of alphaIIbbeta3 is a sufficient but also an imperative prerequisite for activation of alpha2beta1 on platelets

scientific article published on 19 September 2006

Active platelet-binding conformation of plasma von Willebrand factor in young women with acute myocardial infarction

scientific article published on 30 April 2010

Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor-binding protein.

scientific article published on 20 June 2014

Allosteric activation of ADAMTS13 by von Willebrand factor.

scientific article

Amplified endogenous plasmin activity resolves acute thrombotic thrombocytopenic purpura in mice.

scientific article published on 5 October 2017

An open conformation of ADAMTS13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura.

scientific article published on 9 December 2017

Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis

scientific article published on 31 October 2013

Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura

scientific article published on 08 January 2018

Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura

scientific article published on 20 September 2018

Anti-ADAMTS13 autoantibodies in immune-mediated thrombotic thrombocytopenic purpura do not hamper ELISA-based quantification of ADAMTS13 antigen

scientific article published on 27 February 2020

Artificial MiRNA Knockdown of Platelet Glycoprotein lbα: A Tool for Platelet Gene Silencing.

scientific article published on 15 July 2015

Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report

scientific article published on 8 July 2010

Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13

scientific article published on 15 May 2018

Conformational activation of ADAMTS13.

scientific article

Corrigendum: Super-resolution mapping of glutamate receptors in C. elegans by confocal correlated PALM.

scientific article published on 20 May 2016

Crystal structure and substrate-induced activation of ADAMTS13

scientific article published on 22 August 2019

Deficiency of von Willebrand factor protects mice from ischemic stroke

scientific article

Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors

scientific article published on 30 July 2018

Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood.

scientific article published on 27 May 2010

Differences in von Willebrand factor function in type 2A von Willebrand disease and left ventricular assist device-induced acquired von Willebrand syndrome

scientific article published on 08 October 2018

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers.

scientific article published on 19 April 2018

Expanding a Portfolio of (FO-) SPR Surface Chemistries with the Co(III)-NTA Oriented Immobilization of His6-Tagged Bioreceptors for Applications in Complex Matrices

scientific article published on 08 April 2020

Experimental indication for the existence of multiple Trp rotamers in von Willebrand Factor A3 domain

scientific article published in November 2004

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

scientific article published on 28 January 2019

FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients

scientific article

False positive results in chimeraplasty for von Willebrand Disease

scientific article published on 2 February 2006

Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation

scientific article published on 01 July 2018

Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura

scientific article

Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients

scientific article published on 06 December 2018

Glycans of plasma ADAMTS13

scientific article published on 01 November 2016

High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease

scientific article published on 29 December 2017

Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34+ cells are functionally active in an ex vivo flow model of thrombosis

article

Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains

scientific article published on 22 August 2005

Immobilised peptide displaying phages as affinity ligands. Purification of lactoferrin from defatted milk

scientific article published on 10 October 2005

Improved molecular platform for the gene therapy of rare diseases by liver protein secretion.

scientific article published on 25 April 2018

In vivo von Willebrand factor size heterogeneity in spite of the clinical deficiency of ADAMTS-13.

scientific article published in December 2011

Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura.

scientific article

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.

scientific article published on 28 July 2016

Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons

scientific article published in May 2002

Inhibition of von Willebrand factor-platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons

scientific article

Inhibitors of the interactions between collagen and its receptors on platelets.

scientific article published on January 2012

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura.

scientific article published on 5 January 2018

Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.

scientific article

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.

scientific article published on 22 September 2015

Local elongation of endothelial cell-anchored von Willebrand factor strings precedes ADAMTS13 protein-mediated proteolysis

scientific article published on 06 September 2011

Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy

scientific article published on 2 March 2017

MRI assessment of blood outgrowth endothelial cell homing using cationic magnetoliposomes

scientific article published on 17 March 2011

Macroporous monolithic gels, cryogels, with immobilized phages from phage-display library as a new platform for fast development of affinity adsorbent capable of target capture from crude feeds

scientific article

Major Changes of von Willebrand Factor Multimer Distribution in Cirrhotic Patients with Stable Disease or Acute Decompensation

scientific article published on 04 July 2018

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ.

scientific article published on 22 March 2018

Mechanisms of Autoantibody-Induced Pathology.

scientific article

Membrane remodeling processes induced by phospholipase action

scientific article published on 15 April 2014

Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

scientific article published on 21 November 2019

Monoclonal antibody IAC-1 is specific for activated alpha2beta1 and binds to amino acids 199 to 201 of the integrin alpha2 I-domain

scientific article published on 23 March 2004

Multi-step binding of ADAMTS-13 to von Willebrand factor.

scientific article published on 18 September 2009

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura

scientific article

N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura

scientific article

Neutrophil extracellular traps in ischemic stroke thrombi

scientific article published on 11 July 2017

New model of transient strain-dependent autoimmune thrombocytopenia in mice immunized with rat platelets

scientific article

Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain

scientific article published on 28 November 2005

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

scientific article published on 30 January 2019

Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy

scientific article

Platelet rescue by macrophage depletion in obese ADAMTS-13-deficient mice at risk of thrombotic thrombocytopenic purpura.

scientific article published on 9 November 2017

Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice.

scientific article published on 24 July 2015

Platelets at work in primary hemostasis.

scientific article published on 14 April 2011

Potential for Recombinant ADAMTS13 as an Effective Therapy for Acquired Thrombotic Thrombocytopenic Purpura

scientific article

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura

scientific article published on 10 September 2018

Presenting ADAMTS13 antibody and antigen levels predict prognosis in immune-mediated thrombotic thrombocytopenic purpura

scientific article published on 2 June 2017

Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formation

scientific article

Reduced ADAMTS13 levels in patients with acute and chronic cerebrovascular disease

scientific article

Response to Letter Regarding Article, “Plasmin Cleavage of von Willebrand Factor as an Emergency Bypass for ADAMTS13 Deficiency in Thrombotic Microangiopathy”

scientific article published on 01 January 2015

Restoration of plasma von Willebrand factor deficiency is sufficient to correct thrombus formation after gene therapy for severe von Willebrand disease

scientific article

Riboflavin and amotosalen photochemical treatments of platelet concentrates reduce thrombus formation kinetics in vitro.

scientific article published on 30 December 2014

Role of ADAMTS13 in diet-induced liver steatosis.

scientific article published on 7 June 2017

Shear-Stress-Induced Conformational Changes of von Willebrand Factor in a Water–Glycerol Mixture Observed with Single Molecule Microscopy

scientific article published on 15 May 2014

Single particle tracking of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type-1 repeats) molecules on endothelial von Willebrand factor strings

scientific article

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance

scientific article published on 31 January 2020

Super-resolution mapping of glutamate receptors in C. elegans by confocal correlated PALM

scientific article

The distal carboxyterminal domains of murine ADAMTS13 influence proteolysis of platelet-decorated VWF strings in vivo.

scientific article published on October 2010

The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice

scientific article

The role of platelet and endothelial GARP in thrombosis and hemostasis

scientific article

The senotherapeutic nicotinamide riboside raises platelet nicotinamide adenine dinucleotide levels but cannot prevent storage lesion

scientific article published on 25 October 2019

The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice

scientific article published on 27 February 2020

Thrombotic thrombocytopenic pupura (TTP) dinner symposium proceedings

scientific article published on 22 June 2016

Thrombotic thrombocytopenic purpura

article

Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus).

scientific article

Transfer of ADAMTS13 antibody-mediated thrombotic thrombocytopenic purpura via kidney transplantation

scientific article published on 28 February 2019

Two functional active conformations of the integrin {alpha}2{beta}1, depending on activation condition and cell type

scientific article published on 15 August 2005

Understanding therapeutic targets in thrombotic thrombocytopenic purpura

scientific article published on 23 January 2017

Unwinding the von Willebrand factor strings puzzle

scientific article

Update - PROFILE: Early-Stage Researchers Advancing Insights on TTP through a Unique PhD Track

scientific article published on 07 August 2019

Von Willebrand factor and ADAMTS13 impact on the outcome of Staphylococcus aureus sepsis

scientific article published on 22 December 2019

von Willebrand Factor and Platelet Glycoprotein Ib: A Thromboinflammatory Axis in Stroke

scientific article published on 17 December 2019

von Willebrand factor antigen latex immunoassays are affected to a different extent by rheumatoid factor

scientific article published in April 2006

von Willebrand factor but not alpha-thrombin binding to platelet glycoprotein Ibalpha is influenced by the HPA-2 polymorphism

scientific article published on 29 May 2003

von Willebrand factor deficiency does not influence angiotensin II-induced abdominal aortic aneurysm formation in mice

scientific article published in Scientific Reports

von Willebrand factor in experimental malaria-associated acute respiratory distress syndrome

scientific article published on 12 June 2019

List of works by Karen Vanhoorelbeke

A Reliable von Willebrand factor: ristocetin cofactor enzyme-linked immunosorbent assay to differentiate between type 1 and type 2 von Willebrand disease

ADAMTS-13 glycans and conformation-dependent activity.

ADAMTS-13 plasma level determination uncovers antigen absence in acquired thrombotic thrombocytopenic purpura and ethnic differences

ADAMTS13 Gene Mutations Influence ADAMTS13 Conformation and Disease Age-Onset in the French Cohort of Upshaw-Schulman Syndrome

ADAMTS13 and anti-ADAMTS13 antibodies as markers for recurrence of acquired thrombotic thrombocytopenic purpura during remission

ADAMTS13 and anti-ADAMTS13 autoantibodies in thrombotic thrombocytopenic purpura - current perspectives and new treatment strategies

ADAMTS13 deficiency in mice does not affect adipose tissue development

ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis

ADAMTS13 in health and disease

ADAMTS13's tail tale

ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice.

Acquired von Willebrand syndrome in patients on long-term left ventricular assist device support: Results of a Belgian center

Activation of alphaIIbbeta3 is a sufficient but also an imperative prerequisite for activation of alpha2beta1 on platelets

Active platelet-binding conformation of plasma von Willebrand factor in young women with acute myocardial infarction

Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor-binding protein.

Allosteric activation of ADAMTS13 by von Willebrand factor.

Amplified endogenous plasmin activity resolves acute thrombotic thrombocytopenic purpura in mice.

An open conformation of ADAMTS13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura.

Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis

Anti-ADAMTS13 Antibodies and a Novel Heterozygous p.R1177Q Mutation in a Case of Pregnancy-Onset Immune-Mediated Thrombotic Thrombocytopenic Purpura

Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura

Anti-ADAMTS13 autoantibodies in immune-mediated thrombotic thrombocytopenic purpura do not hamper ELISA-based quantification of ADAMTS13 antigen

Artificial MiRNA Knockdown of Platelet Glycoprotein lbα: A Tool for Platelet Gene Silencing.

Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report

Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13

Conformational activation of ADAMTS13.

Corrigendum: Super-resolution mapping of glutamate receptors in C. elegans by confocal correlated PALM.

Crystal structure and substrate-induced activation of ADAMTS13

Deficiency of von Willebrand factor protects mice from ischemic stroke

Deletion of GARP on mouse regulatory T cells is not sufficient to inhibit the growth of transplanted tumors

Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood.

Differences in von Willebrand factor function in type 2A von Willebrand disease and left ventricular assist device-induced acquired von Willebrand syndrome

Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers.

Expanding a Portfolio of (FO-) SPR Surface Chemistries with the Co(III)-NTA Oriented Immobilization of His6-Tagged Bioreceptors for Applications in Complex Matrices

Experimental indication for the existence of multiple Trp rotamers in von Willebrand Factor A3 domain

Exploring the "minimal" structure of a functional ADAMTS13 by mutagenesis and small-angle X-ray scattering

FRETS-VWF73 rather than CBA assay reflects ADAMTS13 proteolytic activity in acquired thrombotic thrombocytopenic purpura patients

False positive results in chimeraplasty for von Willebrand Disease

Functional Genomics for the Identification of Modulators of Platelet-Dependent Thrombus Formation

Generation of Anti-Murine ADAMTS13 Antibodies and Their Application in a Mouse Model for Acquired Thrombotic Thrombocytopenic Purpura

Generation of anti-idiotypic antibodies to detect anti-spacer antibody idiotopes in acute thrombotic thrombocytopenic purpura patients

Glycans of plasma ADAMTS13

High and long-term von Willebrand factor expression after Sleeping Beauty transposon-mediated gene therapy in a mouse model of severe von Willebrand disease

Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34+ cells are functionally active in an ex vivo flow model of thrombosis

Humanization by variable domain resurfacing and grafting on a human IgG4, using a new approach for determination of non-human like surface accessible framework residues based on homology modelling of variable domains

Immobilised peptide displaying phages as affinity ligands. Purification of lactoferrin from defatted milk

Improved molecular platform for the gene therapy of rare diseases by liver protein secretion.

In vivo von Willebrand factor size heterogeneity in spite of the clinical deficiency of ADAMTS-13.

Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura.

Inhibition of Thrombin-Activatable Fibrinolysis Inhibitor and Plasminogen Activator Inhibitor-1 Reduces Ischemic Brain Damage in Mice.

Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons

Inhibition of von Willebrand factor-platelet glycoprotein Ib interaction prevents and reverses symptoms of acute acquired thrombotic thrombocytopenic purpura in baboons

Inhibitors of the interactions between collagen and its receptors on platelets.

Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura.

Keeping von Willebrand Factor under Control: Alternatives for ADAMTS13.

Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.

Local elongation of endothelial cell-anchored von Willebrand factor strings precedes ADAMTS13 protein-mediated proteolysis

Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy

MRI assessment of blood outgrowth endothelial cell homing using cationic magnetoliposomes

Macroporous monolithic gels, cryogels, with immobilized phages from phage-display library as a new platform for fast development of affinity adsorbent capable of target capture from crude feeds

Major Changes of von Willebrand Factor Multimer Distribution in Cirrhotic Patients with Stable Disease or Acute Decompensation

Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ.

Mechanisms of Autoantibody-Induced Pathology.

Membrane remodeling processes induced by phospholipase action

Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

Monoclonal antibody IAC-1 is specific for activated alpha2beta1 and binds to amino acids 199 to 201 of the integrin alpha2 I-domain

Multi-step binding of ADAMTS-13 to von Willebrand factor.

Mutation of the H-bond acceptor S119 in the ADAMTS13 metalloprotease domain reduces secretion and substrate turnover in a patient with congenital thrombotic thrombocytopenic purpura

N-acetylcysteine in preclinical mouse and baboon models of thrombotic thrombocytopenic purpura

Neutrophil extracellular traps in ischemic stroke thrombi

New model of transient strain-dependent autoimmune thrombocytopenia in mice immunized with rat platelets

Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain

Phylogenetic and functional analysis of ADAMTS13 identifies highly conserved domains essential for allosteric regulation

Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy

Platelet rescue by macrophage depletion in obese ADAMTS-13-deficient mice at risk of thrombotic thrombocytopenic purpura.

Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice.

Platelets at work in primary hemostasis.

Potential for Recombinant ADAMTS13 as an Effective Therapy for Acquired Thrombotic Thrombocytopenic Purpura

Preemptive rituximab prevents long-term relapses in immune-mediated thrombotic thrombocytopenic purpura