List of works - Angela Rizzo

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

scientific article

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

scientific article published on 25 June 2015

Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells

scientific article

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration

scientific article

DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents

scientific article published on 25 February 2011

Emerging roles of telomeric chromatin alterations in cancer

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article published on 5 February 2015

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

scientific article published on 11 December 2013

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis.

scientific article

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

scientific article

Hippocampal gene expression is modulated by hypergravity.

scientific article published on February 2004

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

scientific article

Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.

scientific article

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

scientific article published on 27 October 2015

Methods of studying telomere damage induced by quadruplex-ligand complexes ⬇️

scientific article published on 04 March 2012

N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage

scientific article

Nicotinic acetylcholine receptor subtypes in the rat sympathetic ganglion: pharmacological characterization, subcellular distribution and effect of pre- and postganglionic nerve crush

scientific journal article

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

scientific article published on 19 September 2013

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

scientific article published on 30 August 2010

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

scientific article published on 13 April 2016

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

scientific article published on 24 September 2018

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.

scientific article

Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell Death

article

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

scientific article published on 13 July 2009

TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage

scientific article

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

scientific article

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

scientific article

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

scientific article published on 01 April 2019

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect

scientific article

List of works by Angela Rizzo

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

Aromatic core extension in the series of N-cyclic bay-substituted perylene G-quadruplex ligands: increased telomere damage, antitumor activity, and strong selectivity for neoplastic over healthy cells

Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration

DNA Damage Persistence as Determinant of Tumor Sensitivity to the Combination of Topo I Inhibitors and Telomere-Targeting Agents

Emerging roles of telomeric chromatin alterations in cancer

Erratum: identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

Evidence for G-quadruplex in the promoter of vegfr-2 and its targeting to inhibit tumor angiogenesis

Evidence for G-quadruplex in the promoter of VEGFR-2 and its targeting to inhibit tumor angiogenesis.

G-quadruplex ligand RHPS4 potentiates the antitumor activity of camptothecins in preclinical models of solid tumors.

Hippocampal gene expression is modulated by hypergravity.

Identification of novel RHPS4-derivative ligands with improved toxicological profiles and telomere-targeting activities

Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.

Intragenic G-quadruplex structure formed in the human CD133 and its biological and translational relevance

Methods of studying telomere damage induced by quadruplex-ligand complexes ⬇️

N-cyclic bay-substituted perylene G-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage

Nicotinic acetylcholine receptor subtypes in the rat sympathetic ganglion: pharmacological characterization, subcellular distribution and effect of pre- and postganglionic nerve crush

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells

Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells

SIRT6 interacts with TRF2 and promotes its degradation in response to DNA damage.

Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell Death

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage

TRF2 inhibition triggers apoptosis and reduces tumourigenicity of human melanoma cells

TRF2 inhibits a cell-extrinsic pathway through which natural killer cells eliminate cancer cells

TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment

Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect