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List of works by Olaf Heidenreich

A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin

scientific article published on 25 September 2008

AML1/ETO and POU4F1 synergy drives B-lymphoid gene expression typical of t(8;21) acute myeloid leukemia

scientific article published on 08 November 2011

AML1/ETO inhibits AML1/CCAAT-enhancer binding protein-alpha mediated activation of the CD11c promoter and represses CD11c expression in HL60 cells

scientific article published on 01 August 2003

AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia

scientific article (publication date: 15 May 2010)

AML1/MTG8 oncogene suppression by small interfering RNAs supports myeloid differentiation of t(8;21)-positive leukemic cells

scientific article published on 12 December 2002

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia.

scientific article published on 10 May 2017

Analysis of the nuclear distribution of the translocation t(8;21)-derived fusion protein AML1/ETO by confocal laser scanning microscopy

scientific article

BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance.

scientific article published on 17 March 2016

Cleavage of AML1/MTG8 by asymmetric hammerhead ribozymes.

scientific article

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding.

scientific article

Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia

scientific article published on 29 July 2009

Detection and quantification of CBFB/MYH11 fusion transcripts in patients with inv(16)-positive acute myeloblastic leukemia by real-time RT-PCR.

scientific article published on April 2001

Determination of key structure-activity relationships in siRNA delivery with a mixed micelle system.

scientific article

Development of a preclinical orthotopic xenograft model of ewing sarcoma and other human malignant bone disease using advanced in vivo imaging

scientific article (publication date: 2014)

EMMPRIN and its ligand cyclophilin A regulate MT1-MMP, MMP-9 and M-CSF during foam cell formation

scientific article published on 21 August 2009

Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target

scientific article published in October 2000

Exposure of patient-derived mesenchymal stromal cells to TGFB1 supports fibrosis induction in a pediatric acute megakaryoblastic leukemia model

scientific article published on 08 July 2020

Gene silencing by RNAi in mammalian cells

scientific article published on 01 May 2003

H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

scientific article published on 02 April 2020

Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection

scientific article published in October 2006

Inhibition of adhesion molecule expression on human venous endothelial cells by non-viral siRNA transfection.

scientific article

Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression.

scientific article published on 18 July 2012

Leukemic fusion genes MLL/AF4 and AML1/MTG8 support leukemic self-renewal by controlling expression of the telomerase subunit TERT.

scientific article

Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression.

scientific article published on 24 April 2013

Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia.

scientific article published on 25 April 2016

MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo

scientific journal article

Malignant stem cells in childhood ALL: the debate continues!

scientific article published in April 2009

Molecular parameters of siRNA--cell penetrating peptide nanocomplexes for efficient cellular delivery.

scientific article published on 30 April 2013

New insights to the MLL recombinome of acute leukemias

scientific article

Oncogene suppression by small interfering RNAs

scientific article published in August 2004

Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia

scientific article published on 13 December 2018

Proliferation of human primary vascular smooth muscle cells depends on serum response factor

scientific article published on 22 January 2010

RNA interference as a potential tool in the treatment of leukaemia

scientific article

RNase H-independent antisense activity of oligonucleotide N3 '--> P5 ' phosphoramidates.

scientific article published on February 1997

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

scientific article published on 22 January 2021

Real-time RT-PCR for the detection and quantification of AML1/MTG8 fusion transcripts in t(8;21)-positive AML patients

scientific article published on 01 October 1999

Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells

scientific article published on 11 February 2002

Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

scientific article published on 14 March 2022

Specific inhibition of bcr-abl gene expression by small interfering RNA.

scientific article published on 26 September 2002

Suppression of ICAM-1 in human venous endothelial cells by small interfering RNAs

scientific article published on 04 November 2005

Targeted delivery of SiRNA to CD33-positive tumor cells with liposomal carrier systems

scientific article published on 22 February 2010

Targeting MLL-AF4 with short interfering RNAs inhibits clonogenicity and engraftment of t(4;11)-positive human leukemic cells.

scientific article

Targeting oncogenes with siRNAs

scientific article published in January 2009

The HDAC class I-specific inhibitor entinostat (MS-275) effectively relieves epigenetic silencing of the LAT2 gene mediated by AML1/ETO

scientific article published on 16 May 2011

The MLL recombinome of acute leukemias in 2013.

scientific article

The MLL recombinome of acute leukemias in 2017.

scientific article published on 13 July 2017

The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

scientific article

Transient depletion of RUNX1/RUNX1T1 by RNA interference delays tumour formation in vivo

scientific article published on 12 June 2008

UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.

scientific article published on 9 October 2015

Understanding the cancer stem cell.

scientific article published on 27 July 2010

siRNA-mediated AML1/MTG8 depletion affects differentiation and proliferation-associated gene expression in t(8;21)-positive cell lines and primary AML blasts.

scientific article published on May 2006

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