List of works by Kaisa Lehti

A Case of Abnormal Lymphatic-Like Differentiation and Endothelial Progenitor Cell Activation in Neovascularization Associated with Hemi-Retinal Vein Occlusion

scientific article published on May 2015

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients

scientific article published on 01 June 2018

A novel mutation in the matrix metallopeptidase 2 coding gene associated with intrafamilial variability of multicentric osteolysis, nodulosis, and arthropathy

scientific article published on 03 July 2019

Actin-associated protein palladin promotes tumor cell invasion by linking extracellular matrix degradation to cell cytoskeleton

scientific article

Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer

scientific article published on 02 March 2020

Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling duality

scientific article published on 23 April 2021

An Ex Vivo Tissue Culture Model for Fibrovascular Complications in Proliferative Diabetic Retinopathy

scientific article published on 25 January 2019

An MT1-MMP-PDGF receptor-beta axis regulates mural cell investment of the microvasculature

scientific article

An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis

scientific article

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy

scientific article published on 26 October 2012

Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance

scientific article published on 23 June 2021

Eph- and ephrin-dependent mechanisms in tumor and stem cell dynamics

scientific article published on 04 May 2014

EphA2 bears plasticity to tumor invasion

scientific article published on 23 August 2013

EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion

scientific article

Epilysin (MMP-28) induces TGF-beta mediated epithelial to mesenchymal transition in lung carcinoma cells

scientific article published on 29 August 2006

Expression and purification of soluble and inactive mutant forms of membrane type 1 matrix metalloproteinase.

scientific article

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex

scientific article

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

scientific article published on 22 March 2019

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation

scientific article

Fibroblasts in the Tumor Microenvironment: Shield or Spear?

scientific article published on 21 May 2018

Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma

scientific article published on 6 October 2017

High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1

scientific article published on 27 September 2019

Identification of 33 candidate oncogenes by screening for base-specific mutations.

scientific article

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment.

scientific article published on 12 November 2013

Indications of lymphatic endothelial differentiation and endothelial progenitor cell activation in the pathology of proliferative diabetic retinopathy.

scientific article published on 21 April 2015

Integrated Molecular Analysis of Undifferentiated Uterine Sarcomas Reveals Clinically Relevant Molecular Subtypes

scientific article published on 07 January 2019

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

scientific article published in December 2011

Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery

scientific article published on 14 April 2016

Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.

scientific article published on 13 July 2018

Lymphatic Vascular Structures: A New Aspect in Proliferative Diabetic Retinopathy ⬇️

scientific article published on 13 December 2018

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation.

scientific article published in May 2018

MMP14 in Sarcoma: A Regulator of Tumor Microenvironment Communication in Connective Tissues

scientific article published on 28 August 2019

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma.

scientific article

MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis

scientific article published on 24 May 2012

MT1-MMP promotes vascular smooth muscle dedifferentiation through LRP1 processing.

scientific article

MT1-MMP releases latent TGF-beta1 from endothelial cell extracellular matrix via proteolytic processing of LTBP-1.

scientific article published on 6 June 2008

Membrane-type matrix metalloproteases as diverse effectors of cancer progression

scientific article published on 5 April 2017

Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion

scientific article

Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor

scientific article published on 01 March 2021

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor.

scientific article published on 12 May 2011

Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinase

scientific article

PROX1 is a transcriptional regulator of MMP14.

scientific article published on 22 June 2018

Plasmin activates pro-matrix metalloproteinase-2 with a membrane-type 1 matrix metalloproteinase-dependent mechanism

scientific article published on 01 August 2002

Proactive for invasion: Reuse of matrix metalloproteinase for structural memory

scientific article

Quantitative Proteomics Analysis of Vitreous Humor from Diabetic Retinopathy Patients.

scientific article

Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.

scientific article published on July 1996

Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain

scientific article

RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo

scientific article published on 07 February 2017

Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes

scientific article published on December 2008

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage

scientific article published on 07 January 2019

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

scientific article

Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene.

scientific article

Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP.

scientific article published on 23 March 2011

The microenvironment of proliferative diabetic retinopathy supports lymphatic neovascularization.

scientific article published on 13 March 2018

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

scientific article published on 04 February 2020

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization.

scientific article

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