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List of works by Luca Costantino

1-Benzopyran-4-one antioxidants as aldose reductase inhibitors

scientific article published on 01 June 1999

2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives

scientific article

7-Hydroxy-2-substituted-4-H-1-benzopyran-4-one derivatives as aldose reductase inhibitors: a SAR study

scientific article published in September 2001

Aldose reductase does catalyse the reduction of glyceraldehyde through a stoichiometric oxidation of NADPH

scientific article published on 01 November 2000

Anti-inflammatory activity of newly synthesized 2,6-bis-(1,1-dimethylethyl)phenol derivatives

scientific article published on 01 May 1993

Binding of 1-benzopyran-4-one derivatives to aldose reductase: a free energy perturbation study

scientific article published in May 2002

Binding of beta-carbolines and related agents at serotonin (5-HT(2) and 5-HT(1A)), dopamine (D(2)) and benzodiazepine receptors

scientific article

Challenges in the design of multitarget drugs against multifactorial pathologies: a new life for medicinal chemistry?

scientific article published in January 2013

Chapter 3 - Colloidal systems for CNS drug delivery

scientific article published on 08 December 2009

Designed multiple ligands: basic research vs clinical outcomes.

scientific article published on January 2012

Diabetes complications and their potential prevention: aldose reductase inhibition and other approaches

scientific article published on 01 January 1999

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

scientific article published on 18 June 2018

Discovery of new inhibitors of aldose reductase from molecular docking and database screening

scientific article published on 01 May 2002

Drug Delivery to the CNS and Polymeric Nanoparticulate Carriers ⬇️

scientific article published on November 1, 2010

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections

scientific article published on 09 April 2019

Ghrelin receptor modulators and their therapeutic potential

scientific article published on April 2009

Ghrelin receptor modulators: a patent review (2011 - 2014).

scientific article

Glycopeptide-Decorated Nanoparticles as Drug Carriers for CNS: Effects of Surface Coverage and Carbohydrate Type

Growth hormone secretagogue receptor antagonists ⬇️

scientific article published on April 27, 2012

Heteroarylalkanoic acids with possible antiinflammatory activities, III.

scientific article published in October 1985

Interaction of nanoparticles with immunocompetent cells: nanosafety considerations

scientific article published on January 2012

Is there a clinical future for polymeric nanoparticles as brain-targeting drug delivery agents?

scientific article published on 7 November 2011

Isoxazolo-[3,4-d]-pyridazin-7-(6H)-one as a potential substrate for new aldose reductase inhibitors

scientific article published on 01 June 1999

Magnetic and optical bistability in tetrairon(III) single molecule magnets functionalized with azobenzene groups

scientific article

Methods for synthesis and uses of inhibitors of Ghrelin O-acyltransferase inhibitors as potential therapeutic agents for obesity and diabetes ⬇️

scientific article published on October 12, 2010

Molecular dynamics simulations of the structure of aldose reductase complexed with the inhibitor tolrestat

scientific article published on 01 March 1998

Nanoparticles as drug delivery agents specific for CNS: in vivo biodistribution

scientific article

Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures

scientific article published on 22 May 2006

New Chromane-Based Derivatives as Inhibitors of Salicylate Synthase (MbtI): Preliminary Biological Evaluation and Molecular Modeling Studies

scientific article published on 21 June 2018

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents

scientific article published on 01 December 2019

Nitrophenyl derivatives as aldose reductase inhibitors

scientific article published in December 2002

Novel triazole derivatives with improved receptor activity and bioavailability properties as ghrelin antagonists of growth hormone secretagogue receptors (WO2012035124): a patent evaluation ⬇️

scientific article published on July 19, 2012

On the prodrug potential of novel aldose reductase inhibitors with diphenylmethyleneaminooxycarboxylic acid structure

scientific article published in February 2002

Oxidative Modification of Aldose Reductase Induced by Copper Ion. Factors and Conditions Affecting the Process†

scientific article published on 01 October 1998

Oxidative modification of aldose reductase induced by copper ion. Definition of the metal-protein interaction mechanism

scientific article published on 14 August 2002

PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid.

scientific article published on 4 February 2010

Peptide-derivatized biodegradable nanoparticles able to cross the blood-brain barrier

scientific article

Polymeric nanoparticles for the drug delivery to the central nervous system

scientific article published on February 2008

Privileged structures as leads in medicinal chemistry.

scientific article

Quantitative measurement of proton dissociation and tautomeric constants of apigeninidin

STAT 3 as a target for cancer drug discovery

scientific article

Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution.

scientific article published on 23 March 2010

Structural bases for the inhibition of aldose reductase by phenolic compounds

scientific article published on 01 May 2000

Synthesis and aldose reductase inhibitory activities of novel thienocinnolinone derivatives

scientific article published in March 2004

Synthesis and aldose reductase inhibitory activity of 5-arylidene-2,4-thiazolidinediones.

scientific article published on April 2002

Synthesis and aldose reductase inhibitory activity of a new series of benz[h]cinnolinone derivatives

scientific article published on 01 August 2000

Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives

scientific article published on 01 June 1998

Synthesis of novel benzoic acid derivatives with benzothiazolyl subunit and evaluation as aldose reductase inhibitors

scientific article

Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors.

scientific article published on 5 March 2009

Synthesis, activity, and molecular modeling of a new series of tricyclic pyridazinones as selective aldose reductase inhibitors

scientific article published on 01 October 1996

Targeting the central nervous system: in vivo experiments with peptide-derivatized nanoparticles loaded with Loperamide and Rhodamine-123.

scientific article

Thienocinnolinone alkanoic acid derivatives as aldose reductase inhibitors

scientific article published on 01 January 2006

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