List of works by Jakob Begun

A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy

scientific article published on 01 June 2020

A systematic review and meta-analysis of mindfulness based interventions and yoga in inflammatory bowel disease

scientific article published on 14 November 2018

A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension

scientific article published on 10 March 2024

Aeromedical retrievals for gastrointestinal disorders in rural and remote Australia: the need for improved access to specialist advice

scientific article published on 01 May 2020

An Extremes of Phenotype Approach Confirms Significant Genetic Heterogeneity in Patients with Ulcerative Colitis

scientific article published in 2022

Australian consensus statements for the regulation, production and use of faecal microbiota transplantation in clinical practice

scientific article published on 11 February 2020

Autophagy at the crossroads of metabolism and cellular defense.

scientific article

Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis

scientific article

Cancer therapeutics with epigallocatechin-3-gallate encapsulated in biopolymeric nanoparticles

scientific article published on 14 December 2016

Cannabidiol - Help and hype in targeting mucosal diseases

scientific article published in January 2024

Clinical decision support improves quality of care in patients with ulcerative colitis

scientific article published on 07 March 2019

Colonic microbiota can promote rapid local improvement of murine colitis by thioguanine independently of T lymphocytes and host metabolism.

scientific article published on 13 July 2016

Colonic thioguanine pro-drug: Investigation of microbiome and novel host metabolism

scientific article published on 4 October 2017

Comprehensive systematic review and pooled analysis of real-world studies evaluating immunomodulator and biologic therapies for chronic pouchitis treatment

scientific article published in December 2023

Crohn's Colitis Care (CCCare): bespoke cloud-based clinical management software for inflammatory bowel disease

scientific article published on 08 November 2020

Crystal structure of an Xrcc4-DNA ligase IV complex

scientific article

Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration

scientific article published on 24 January 2002

DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans

scientific article

Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis

scientific article

Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1

scientific article published on 26 August 2019

Does Improving Depression Symptoms in Young Adults With Inflammatory Bowel Disease Alter Their Microbiome?

scientific article published on 5 June 2024

Enterococcus faecalis AHG0090 is a Genetically Tractable Bacterium and Produces a Secreted Peptidic Bioactive that Suppresses Nuclear Factor Kappa B Activation in Human Gut Epithelial Cells.

scientific article

Enteroliths in a Kock continent ileostomy: case report and review of the literature.

scientific article published on 10 June 2015

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

scientific article published on 06 September 2021

Faecal calprotectin testing for identifying patients with organic gastrointestinal disease: systematic review and meta-analysis

scientific article published on 03 November 2019

Gastrointestinal ultrasound in inflammatory bowel disease care: Patient perceptions and impact on disease-related knowledge

scientific article published on 09 October 2019

Gastrointestinal ultrasound in inflammatory bowel disease: an underused resource with potential paradigm-changing application.

scientific article published on 3 February 2018

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

scientific article published on 6 June 2016

Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

Guselkumab in Patients With Moderately to Severely Active Ulcerative Colitis: QUASAR Phase 2b Induction Study

scientific article published in December 2023

Guselkumab plus golimumab combination therapy versus guselkumab or golimumab monotherapy in patients with ulcerative colitis (VEGA): a randomised, double-blind, controlled, phase 2, proof-of-concept trial

scientific article published in April 2023

Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver

scientific article published on 16 January 2023

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22

scientific article published on 28 June 2016

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

scientific article published on 18 February 2014

Inflammatory bowel disease in the clinic: Escalation and de-escalation of therapy: A longitudinal case-based discussion

scientific article published on 01 June 2016

Infliximab, adalimumab and vedolizumab concentrations across pregnancy and vedolizumab concentrations in infants following intrauterine exposure

scientific article published on 27 September 2020

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy

scientific article published on 18 June 2015

Interleukin-22: friend or foe?

scientific article published on 01 April 2019

Letter: vedolizumab drug concentrations in neonates following intrauterine exposure

scientific article published on 01 December 2018

Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.

scientific article

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

scientific article published on 18 September 2019

MUC13 Cell Surface Mucin Limits Salmonella Typhimurium Infection by Protecting the Mucosal Epithelial Barrier

scientific article published in 2023

MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity

scientific article published on 19 August 2019

Malnutrition and quality of life among adult inflammatory bowel disease patients

scientific article published on 14 November 2019

Mindfulness-Based Cognitive Therapy Experiences in Youth With Inflammatory Bowel Disease and Depression: Protocol for a Mixed Methods Qualitative Study

scientific article published on 24 July 2019

Monitoring Inflammatory Bowel Disease in Pregnancy using Gastrointestinal Ultrasonography

scientific article published on 28 April 2020

Personalizing inflammatory bowel disease treatment symposium: Foreward

scientific article published on 01 September 2018

Positioning biologics-A case-based discussion: Ustekinumab

scientific article published on 01 September 2018

Practical management of inflammatory bowel disease patients during the COVID-19 pandemic: expert commentary from the Gastroenterological Society of Australia Inflammatory Bowel Disease faculty

scientific article published on 01 July 2020

Predictors in inflammatory bowel disease: Looking into the magic ball: Session one summary

scientific article published on 01 September 2018

Preexisting tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia

scientific article published in January 2024

Protocol for a Single-Arm Feasibility Study of Photobiomodulation for Fatigue, Depression, and Pain in Inflammatory Bowel Disease

scientific article published on 2 August 2023

Protocol for a pilot randomised controlled trial of mindfulness-based cognitive therapy in youth with inflammatory bowel disease and depression

scientific article published on 20 April 2019

Review article: consensus statements on therapeutic drug monitoring of anti-tumour necrosis factor therapy in inflammatory bowel diseases.

scientific article

Selectively targeting the gut in inflammatory bowel disease: Session four summary

scientific article published on 01 September 2018

Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses

scientific article

Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model

scientific article

Switching Australian patients with moderate to severe inflammatory bowel disease from originator to biosimilar infliximab: a multicentre, parallel cohort study

scientific article published on 17 October 2020

Systematic review: Defining, diagnosing and monitoring small bowel strictures in Crohn's disease on intestinal ultrasound

scientific article published on 4 March 2024

The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium

scientific article

The gut bacterium and pathobiont Bacteroides vulgatus activates NF-κB in a human gut epithelial cell line in a strain and growth phase dependent manner.

scientific article

The impact of clinical experience on decision-making regarding the treatment and management of mild-to-moderate ulcerative colitis

scientific article published in January 2023

The psychosocial burden of inflammatory bowel disease in adolescents and young adults

scientific article published on 25 August 2020

The role of IL-22 in the resolution of sterile and nonsterile inflammation.

scientific article

The role of barrier function, autophagy, and cytokines in maintaining intestinal homeostasis.

scientific article

The worm has turned--microbial virulence modeled in Caenorhabditis elegans

scientific article

Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's disease

scientific article

Vedolizumab and Ustekinumab Levels in Pregnant Women With Inflammatory Bowel Disease and Infants Exposed In Utero

scientific article published in March 2024

Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford

scientific article published on 01 August 2020

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