Search filters

List of works by Thomas E. Spratt

A fluoroquinolone antibiotic with a methoxy group at the 8 position yields reduced generation of 8-oxo-7,8-dihydro-2'-deoxyguanosine after ultraviolet-A irradiation.

scientific article published on August 1997

Absolute configuration of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol formed metabolically from 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

scientific article published in September 1997

Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase I.

scientific article

An unprecedented nucleic acid capture mechanism for excision of DNA damage

scientific article

Association studies of excision repair cross-complementation group 1 (ERCC1) haplotypes with lung and head and neck cancer risk in a Caucasian population

scientific article published on 21 September 2010

Characterization of dibenzo[a,l]pyrene-trans-11,12-diol (dibenzo[def,p]chrysene) glucuronidation by UDP-glucuronosyltransferases.

scientific article

DNA Polymerases η and ζ Combine to Bypass O(2)-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens.

scientific article

Differences in the rate of repair of O6-alkylguanines in different sequence contexts by O6-alkylguanine-DNA alkyltransferase

scientific article published in November 2007

Different mechanisms for the photoinduced production of oxidative DNA damage by fluoroquinolones differing in photostability

scientific article published on 01 September 1999

Differential repair of polycyclic aromatic hydrocarbon DNA adducts from an actively transcribed gene.

scientific article

Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus.

scientific article

Escherichia coli DNA polymerase I (Klenow fragment) uses a hydrogen-bonding fork from Arg668 to the primer terminus and incoming deoxynucleotide triphosphate to catalyze DNA replication.

scientific article

Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.

scientific article published on January 1988

Facile syntheses of O(2)-[4-(3-pyridyl-4-oxobut-1-yl]thymidine, the major adduct formed by tobacco specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its site-specifically adducted oligodeoxynucleotides.

scientific article published on 5 May 2011

Formation of purine-purine mispairs by Sulfolobus solfataricus DNA polymerase IV.

scientific article published on 11 July 2008

Functional characterization of low-prevalence missense polymorphisms in the UDP-glucuronosyltransferase 1A9 gene.

scientific article published on 09 July 2009

Gastric carcinogenesis: 2-chloro-4-methylthiobutanoic acid, a novel mutagen in salted, pickled Sanma hiraki fish, or similarly treated methionine

scientific article published in January 1996

Glucuronidation of tobacco-specific nitrosamines by UGT2B10

scientific article published on 31 January 2008

Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells.

scientific article published on 9 January 2017

Human DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency.

scientific article published on 11 May 2015

Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity

scientific article

Identification of hydrogen bonds between Escherichia coli DNA polymerase I (Klenow fragment) and the minor groove of DNA by amino acid substitution of the polymerase and atomic substitution of the DNA.

scientific article published in March 2001

Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase.

scientific article published on April 2009

In vitro epsilon RNA-dependent protein priming activity of human hepatitis B virus polymerase.

scientific article

Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase beta and ligase III/XRCC1.

scientific article published in June 2010

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in human hepatic microsomes by ipomeanol analogs--an exploratory study

scientific article published on 01 July 1998

Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress.

scientific article published on 18 July 2013

Klenow Fragment−DNA Interaction Required for the Incorporation of Nucleotides Opposite Guanine and O6-Methylguanine ⬇️

scientific article published on October 28, 1997

Low fidelity bypass of O(2)-(3-pyridyl)-4-oxobutylthymine, the most persistent bulky adduct produced by the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by model DNA polymerases.

scientific article

Modulations of benzo[a]pyrene-induced DNA adduct, cyclin D1 and PCNA in oral tissue by 1,4-phenylenebis(methylene)selenocyanate.

scientific article published on April 2009

Mutagenic Replication of N2-Deoxyguanosine Benzo[a]pyrene Adducts by Escherichia coli DNA Polymerase I and Sulfolobus solfataricus DNA Polymerase IV.

scientific article published on 12 April 2017

N2 -Substituted 2'-Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ.

scientific article

O6-Alkylguanine−DNA Alkyltransferases Repair O6-Methylguanine in DNA with Michaelis−Menten-like Kinetics ⬇️

scientific article published on November 1, 2003

Pyridyloxobutyl adduct O6-[4-oxo-4-(3-pyridyl)butyl]guanine is present in 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone-treated DNA and is a substrate for O6-alkylguanine-DNA alkyltransferase.

scientific article published in May 1997

Pyridyloxobutylation of Guanine Residues by 4-[(Acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone Generates Substrates ofO6-Alkylguanine−DNA Alkyltransferase

scientific article published on 01 September 1996

Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O2-alkylthymidines in human cells.

scientific article

Stereochemistry of the in vitro and in vivo methylation of DNA by (R)- and (S)-N-[2H1,3H]methyl-N-nitrosourea and (R)- and (S)-N-nitroso-N-[2H1,3H]methyl-N-methylamine

scientific article published on 01 December 1997

Structure of purine-purine mispairs during misincorporation and extension by Escherichia coli DNA polymerase I.

scientific article published in March 2006

Structure of the hydrogen bonding complex of O6-methylguanine with cytosine and thymine during DNA replication ⬇️

scientific article published on August 15, 1997

Synthesis of DNA oligonucleotides containing site-specifically incorporated O6-[4-oxo-4-(3-pyridyl)butyl]guanine and their reaction with O6-alkylguanine-DNA alkyltransferase.

scientific article published in February 1999

Tobacco-specific nitrosamine-derived O2-alkylthymidines are potent mutagenic lesions in SOS-induced Escherichia coli

scientific article published on 28 October 2011

Unexpected mutagen in fish

scientific article published in April 1995

Yeast DNA polymerase η makes functional contacts with the DNA minor groove only at the incoming nucleoside triphosphate ⬇️

scientific article published on April 11, 2003

Paulina is supported by:

About Paulina

Help