List of works - Jason Gorman

A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike

scientific article published on 04 July 2020

A short segment in the HIV-1 gp120 V1/V2 region is a major determinant of neutralization resistance to PG9-like antibodies.

scientific article published on 13 September 2012

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

scientific article

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

scientific article

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

scientific article published on 01 July 2019

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

scientific article published on 10 April 2019

Blocking α4β7 integrin binding to SIV does not improve virologic control

scientific article published on 05 September 2019

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

scientific article

Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article published on 24 May 2016

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

scientific article published on 17 November 2020

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide

scientific article

DNA Curtains for High-Throughput Single-Molecule Optical Imaging

scientific article published on 01 January 2010

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

scientific article published on 14 December 2020

Dynamic basis for one-dimensional DNA scanning by the mismatch repair complex Msh2-Msh6.

scientific article

Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

scientific article published on 31 May 2016

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

scientific article published on 04 June 2018

Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

scientific article published on 09 November 2021

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

scientific article

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

scientific article published on 21 March 2018

Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer

article

Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields

scientific article published on 02 October 2019

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

scientific article published on 12 March 2019

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

scientific article

Nanofabricated racks of aligned and anchored DNA substrates for single-molecule imaging

scientific article

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

scientific article

Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies

scientific article published on January 2017

Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike

scientific article published on 18 June 2020

Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike

scientific article published on 22 July 2020

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

article

Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles

scientific article

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

scientific article published on 13 September 2020

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

scientific article published on 19 November 2020

Recombinant Env proteins that bind the quaternary-specific, V1/V2-directed PGT antibodies.

scientific article

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

article

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

scientific article

Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

scientific article published in Nature Communications

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

scientific article published on 4 March 2015

Single-Molecule FRET Delineates Asymmetric Trimer Conformations during HIV-1 Entry

article by Xiaochu Ma et al published February 2017 in Biophysical Journal

Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair

scientific article

Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies

scientific article

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage

scientific article published on 03 September 2019

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

scientific article published on 09 July 2021

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.

article by Yiwei Chen et al published April 2021 in Nature

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.

scientific article

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

scientific article

Structure of Escherichia coli YfdW, a type III CoA transferase

scientific article published on 25 February 2004

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

scientific article published on 01 April 2020

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site

scientific article published on 31 August 2016

Structure of serine acetyltransferase fromHaemophilus influenzaeRd

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

scientific article published on 8 March 2017

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

scientific article published on 23 June 2020

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

scientific article published on 21 July 2020

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes ⬇️

scientific article published on 12 October 2020

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

scientific article

Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles

scientific article published on 29 June 2020

Target search dynamics during post-replicative mismatch repair

scientific article published on 23 January 2013

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article

The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion

scientific article published on 23 December 2012

Transplanting supersites of HIV-1 vulnerability

scientific article

Uncleaved Soluble gp140 Constructs with Retained Native-like Trimer Conformation and Antigenicity.

scientific article published in October 2014

V1/V2-directed antibodies elicited in RV144 vaccinees bind to a structurally polymorphic site

scientific article published on 13 September 2012

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

scientific article

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

scientific article

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

scientific article published on May 2017

Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice

scientific article

Visualizing one-dimensional diffusion of proteins along DNA.

scientific article published on 05 August 2008

List of works by Jason Gorman

A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike

A short segment in the HIV-1 gp120 V1/V2 region is a major determinant of neutralization resistance to PG9-like antibodies.

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

Blocking α4β7 integrin binding to SIV does not improve virologic control

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide

DNA Curtains for High-Throughput Single-Molecule Optical Imaging

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

Dynamic basis for one-dimensional DNA scanning by the mismatch repair complex Msh2-Msh6.

Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer

Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

Nanofabricated racks of aligned and anchored DNA substrates for single-molecule imaging

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

Ontogeny-based immunogens for the induction of V2-directed HIV broadly neutralizing antibodies

Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike

Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

Recombinant Env proteins that bind the quaternary-specific, V1/V2-directed PGT antibodies.

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

Single-Molecule FRET Delineates Asymmetric Trimer Conformations during HIV-1 Entry

Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair

Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies

Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

Structure of Escherichia coli YfdW, a type III CoA transferase

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site

Structure of serine acetyltransferase fromHaemophilus influenzaeRd

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes ⬇️

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles

Target search dynamics during post-replicative mismatch repair

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion

Transplanting supersites of HIV-1 vulnerability

Uncleaved Soluble gp140 Constructs with Retained Native-like Trimer Conformation and Antigenicity.

V1/V2-directed antibodies elicited in RV144 vaccinees bind to a structurally polymorphic site

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice

Visualizing one-dimensional diffusion of proteins along DNA.