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List of works by Trevor Biden

A comprehensive lipidomic screen of pancreatic β-cells using mass spectroscopy defines novel features of glucose-stimulated turnover of neutral lipids, sphingolipids and plasmalogens

scientific article published on 13 April 2016

A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking.

scientific article published on April 2011

Active transport of myo-inositol in rat pancreatic islets.

scientific article published on June 1986

Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta

scientific article published on 24 February 2004

Alteration of endoplasmic reticulum lipid rafts contributes to lipotoxicity in pancreatic β-cells

scientific article published on 29 July 2013

Bad news for beta-cell apoptosis.

scientific article published on August 2009

Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes

scientific article published in September 2005

Cross-talk between muscarinic- and adenosine-receptor signalling in the regulation of cytosolic free Ca2+ and insulin secretion ⬇️

scientific article published on August 1, 1993

Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets ⬇️

scientific article published on July 28, 2012

Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signaling.

scientific article published on 30 June 2008

Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells

scientific journal article

Deletion of protein kinase Cδ in mice modulates stability of inflammatory genes and protects against cytokine-stimulated beta cell death in vitro and in vivo.

scientific article published on 20 November 2010

Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle

scientific journal article

Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass

scientific article published on 17 October 2018

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.

scientific article published on 7 October 2009

Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function

scientific article published on 01 May 1985

Effects of ketone bodies on insulin release and islet-cell metabolism in the rat ⬇️

scientific article published on May 15, 1983

Evidence for phosphatidylinositol hydrolysis in pancreatic islets stimulated with carbamoylcholine. Kinetic analysis of inositol polyphosphate metabolism ⬇️

scientific article published on July 15, 1992

Evidence for selective coupling of alpha 1-adrenergic receptors to phospholipase C-beta 1 in rat neonatal cardiomyocytes

scientific article published on 6 August 2001

Exposure to depolarizing concentrations of K+ inhibits hormonally-induced calcium influx in rat liver ⬇️

scientific article published on June 30, 1988

Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes

scientific article published on 28 December 2012

Glucose homeostasis in mice is transglutaminase 2 independent

scientific article

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

scientific article published on 13 February 2018

High-fat diet increases autophagic flux in pancreatic beta cells in vivo and ex vivo in mice

scientific article published on 14 June 2015

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

scientific article

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

scientific article

Increased fatty acid desaturation and enhanced expression of stearoyl coenzyme A desaturase protects pancreatic beta-cells from lipoapoptosis.

scientific article published on October 2005

Inhibition of PKCalpha induces a PKCdelta-dependent apoptotic program in salivary epithelial cells.

scientific article published on March 2003

Inhibition of PKCepsilon improves glucose-stimulated insulin secretion and reduces insulin clearance.

scientific article published in October 2007

Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells ⬇️

scientific article published on October 15, 1984

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus.

scientific article published on 18 March 2014

Lysosomal acid lipase and lipophagy are constitutive negative regulators of glucose-stimulated insulin secretion from pancreatic beta cells.

scientific article published on 23 October 2013

Nutrient Stimulation Results in a Rapid Ca2+-dependent Threonine Phosphorylation of Myosin Heavy Chain in Rat Pancreatic Islets and RINm5F Cells ⬇️

scientific article published on August 28, 1998

Oleate disrupts cAMP signaling, contributing to potent stimulation of pancreatic β-cell autophagy

scientific article published on 05 December 2018

PKC alpha is activated but not required during glucose-induced insulin secretion from rat pancreatic islets

scientific article published in January 2004

PKCdelta blues for the beta-cell

scientific article

PKCdelta is required for mitochondrial-dependent apoptosis in salivary epithelial cells.

scientific article

Phospholipase C-gamma mediates the hydrolysis of phosphatidylinositol, but not of phosphatidylinositol 4,5-bisphoshate, in carbamylcholine-stimulated islets of langerhans

scientific article

Phospholipase Cdelta(1) does not mediate Ca(2+) responses in neonatal rat cardiomyocytes

scientific article published in July 2003

Phospholipase D1 regulates secretagogue-stimulated insulin release in pancreatic beta-cells.

scientific article published on 14 April 2004

Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

scientific article published on 11 October 2018

Protein kinase C function in muscle, liver, and beta-cells and its therapeutic implications for type 2 diabetes

scientific article published on July 2008

Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis

scientific article published on February 1999

Quantitative and functional characterization of muscarinic receptor subtypes in insulin-secreting cell lines and rat pancreatic islets.

scientific article published on March 2000

Rapid increases in inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate and cytosolic free Ca2+ in agonist-stimulated pancreatic acini of the rat. Effect of carbachol, caerulein and secretin.

scientific article published on February 1987

Reduced endoplasmic reticulum (ER)-to-Golgi protein trafficking contributes to ER stress in lipotoxic mouse beta cells by promoting protein overload.

scientific article

Regulation of inositol 1,4,5-trisphosphate metabolism in insulin-secreting RINm5F cells.

scientific article published on April 1988

Regulation of mitochondrial metabolism in murine skeletal muscle by the medium-chain fatty acid receptor Gpr84

scientific article published on 15 August 2019

Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells.

scientific article published on 31 October 2013

Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction.

scientific article published on May 2012

Secretin stimulates cyclic AMP and inositol trisphosphate production in rat pancreatic acinar tissue by two fully independent mechanisms

scientific article

Structural and biochemical studies of human galanin: NMR evidence for nascent helical structures in aqueous solution.

scientific article published on April 1995

Structural subtypes of the dopamine D2 receptor are functionally distinct: expression of the cloned D2A and D2B subtypes in a heterologous cell line

scientific article published on June 1, 1992

Sulfonylureas as Concomitant Insulin Secretagogues and NLRP3 Inflammasome Inhibitors.

scientific article

Sweet and sour β-cells: ROS and Hif1α induce Warburg-like lactate production during type 2 diabetes.

scientific article published on June 2013

Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism

scientific article

The diverse roles of protein kinase C in pancreatic beta-cell function.

scientific article

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice

scientific article

Treatment of type 2 diabetes with the designer cytokine IC7Fc

scientific article published on 25 September 2019

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