List of works by David Smith

A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation

scientific article

Analysis of Toxic Amyloid Fibril Interactions at Natively Derived Membranes by Ellipsometry

scientific article published on 14 July 2015

Analysis of protein interactions at native chloroplast membranes by ellipsometry

scientific article

Binding of Dopamine to Alpha-Synuclein is Mediated by Specific Conformational States

scientific article published on 02 July 2013

Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease amyloid-beta peptide.

scientific article published on 13 February 2007

Copper Binding and Subsequent Aggregation of α-Synuclein Are Modulated by N-Terminal Acetylation and Ablated by the H50Q Missense Mutation.

scientific article published on 12 August 2016

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

scientific article

Crystal structure of monomeric human  -2-microglobulin reveals clues to its amyloidogenic properties ⬇️

scientific article

Deciphering drift time measurements from travelling wave ion mobility spectrometry-mass spectrometry studies

scientific article published in January 2009

Dimeric structures of alpha-synuclein bind preferentially to lipid membranes

scientific article

Distinct higher-order α-synuclein oligomers induce intracellular aggregation

scientific article

Dopamine promotes alpha-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway

scientific article published on 9 June 2005

Elongated oligomers in beta2-microglobulin amyloid assembly revealed by ion mobility spectrometry-mass spectrometry

scientific article

Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein†

scientific article published on 08 January 2008

Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy

scientific article published in July 2003

In vitro characterization of Pittsburgh compound-B binding to Lewy bodies.

scientific article published in September 2007

MALDI-MSI for the analysis of a 3D tissue-engineered psoriatic skin model ⬇️

scientific article

Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry

scientific article published on 2 October 2007

Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease

scholarly article

Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease ⬇️

scientific article

Quantification of ligand binding to G-protein coupled receptors on cell membranes by ellipsometry

scientific article

Quantification of proteins in whole blood, plasma and DBS, with element-labelled antibody detection by ICP-MS

scientific article published on 20 March 2019

Recapitulating Parkinson's disease pathology in a three-dimensional human neural cell culture model

article

Recombinant " IMS TAG" proteins--a new method for validating bottom-up matrix-assisted laser desorption/ionisation ion mobility separation mass spectrometry imaging

scientific article

Role of the N and C-terminal strands of beta 2-microglobulin in amyloid formation at neutral pH.

scientific article

Role of the single disulphide bond of beta(2)-microglobulin in amyloidosis in vitro

scientific article

Self-selecting peer groups formed within the laboratory environment have a lasting effect on individual student attainment and working practices

scientific article published on 07 June 2020

Stabilization of neurotoxic soluble beta-sheet-rich conformations of the Alzheimer's disease amyloid-beta peptide

scientific article

Stacked sets of parallel, in-register beta-strands of beta2-microglobulin in amyloid fibrils revealed by site-directed spin labeling and chemical labeling

scientific article

Structure and dynamics of oligomeric intermediates in β2-microglobulin self-assembly

scientific article published on September 2011

Study of receptor-chaperone interactions using the optical technique of spectroscopic ellipsometry

scientific article published on July 2011

The Characterization of an Aggregated Three-Dimensional Cell Culture Model by Multimodal Mass Spectrometry Imaging

scientific article published on 29 July 2020

The Division of Amyloid Fibrils: Systematic Comparison of Fibril Fragmentation Stability by Linking Theory with Experiments

scientific article published on 29 August 2020

The N-terminal residues 43 to 60 form the interface for dopamine mediated α-synuclein dimerisation.

scientific article

Trifluoromethyldiazirine: an effective photo-induced cross-linking probe for exploring amyloid formation

scientific article

Who goes where? The importance of peer groups on attainment and the student use of the lecture theatre teaching space

scientific article published on 21 August 2018

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