List of works - Gerard O'Keeffe

28 Growth Differentiation Factor-5 (GDF-5) expression in the rat brain: developmental regulator, potential treatment?

scientific article published in November 2002

4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells

scientific article published on 05 December 2019

6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo

scientific article

A Case Study in the Use of Primary Literature in the Context of Authentic Learning Pedagogy in the Undergraduate Neuroscience Classroom

scientific article published on 15 November 2017

A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease.

scientific article published on 2 June 2016

A new role for placental IL-6 signalling in determining neurodevelopmental outcome

scientific article

A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role?

scientific article published on 02 November 2018

A practical description and student perspective of the integration of radiology into lower limb musculoskeletal anatomy

scientific article published on 29 July 2016

Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker

scientific article

Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons

scientific article published on 21 January 2020

An Attitudinal Survey of Undergraduate Neuroscience Students Regarding Their Views on the Relevance of Lectures to their Education

scientific article published on 15 November 2017

Anatomy education for the YouTube generation

scientific article published on 9 June 2015

Association between preeclampsia and autism spectrum disorder: a population-based study

scientific article published on 17 September 2019

Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring: A Systematic Review and Meta-analysis

scientific article published on 01 August 2018

Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma

scientific article published on 23 April 2020

BMP-Smad 1/5/8 signalling in the development of the nervous system.

scientific article published on 24 July 2013

BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons.

scientific article published on 3 July 2013

Cadaveric anatomy in the future of medical education: What is the surgeons view?

scientific article

Canonical BMP-Smad signalling promotes neurite growth in rat midbrain dopaminergic neurons

scientific article published on 29 March 2014

Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult

scientific article published on 29 July 2014

Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells.

scientific article published on 21 February 2017

Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation

scientific article published on 3 June 2016

Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease

scientific article published on 19 February 2014

Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy

scientific article

Effects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro

scientific article

Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis.

scientific article published on 10 February 2017

Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth.

scientific article published on 7 February 2017

Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease

scientific article published on 19 June 2018

Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?

scientific article published on 9 February 2012

Exposure to Hypertensive Disorders of Pregnancy Increases the Risk of Autism Spectrum Disorder in Affected Offspring

scientific article

Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease.

scientific article

Expression of growth differentiation factor-5 in the developing and adult rat brain.

scientific article published in July 2004

Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling

scientific article published on 13 September 2019

Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T α-synuclein.

scientific article published on 11 January 2019

Googling in anatomy education: Can google trends inform educators of national online search patterns of anatomical syllabi?

scientific article published on 22 August 2016

Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol.

scientific article published on 5 October 2017

IL-1β inhibits axonal growth of developing sympathetic neurons

scientific article published on 21 July 2011

Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease

scientific article published on 14 April 2014

LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation

scientific article published on 12 June 2014

Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta.

scientific article published on 30 August 2016

Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling

scientific article published on 08 May 2017

Microbiota and neurodevelopmental windows: implications for brain disorders

scientific article

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

scientific article

Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development.

scientific article published on 18 April 2013

Mild prenatal hypoxia-ischemia leads to social deficits and central and peripheral inflammation in exposed offspring

scientific article published on 16 January 2018

Mitogen-activated protein kinase phosphatase (MKP)-1 as a neuroprotective agent: promotion of the morphological development of midbrain dopaminergic neurons.

scientific article published on 13 April 2013

Modular and coordinated expression of immune system regulatory and signaling components in the developing and adult nervous system

scientific article published on 28 August 2015

NGF-promoted axon growth and target innervation requires GITRL-GITR signaling

scientific article

Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation.

scientific article

Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management

scientific article

Neurotrophic factor therapy for Parkinson's disease: past, present and future

scientific article published on February 2016

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.

scientific article

Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism

scientific article published on 21 December 2015

Nuclear factor-kappaB activation via tyrosine phosphorylation of inhibitor kappaB-alpha is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons

scientific article

Peroxisomes: the neuropathological consequences of peroxisomal dysfunction in the developing brain.

scientific article published on 02 July 2013

Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants

scientific article published in Scientific Reports

Predicting infant neurodevelopmental outcomes using the placenta?

scientific article published on 2 May 2014

Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis

scientific article published on 20 July 2019

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood

scientific article published on 17 June 2015

Radiologist's views on anatomical knowledge amongst junior doctors and the teaching of anatomy in medical curricula

scientific article published on 04 February 2019

Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation

scientific article published on 15 February 2016

Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region

scientific article

Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region

scientific article published on 02 November 2015

Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor

scientific article

Regulation of neurite growth by tumour necrosis superfamily member RANKL.

scientific article published on 8 January 2013

Roles for the TGFβ superfamily in the development and survival of midbrain dopaminergic neurons.

scientific article published on 07 February 2014

Romidepsin induces caspase-dependent cell death in human neuroblastoma cells

scientific article

Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease.

scientific article published in November 2017

The Effect of Hypertensive Disorders of Pregnancy on the Risk of ADHD in the Offspring.

scientific article published in January 2017

The Epigenome as a therapeutic target for Parkinson's disease.

scientific article

The association between caesarean section and cognitive ability in childhood

scientific article published on 22 October 2019

The class II histone deacetylases as therapeutic targets for Parkinson's disease

scientific article published on 09 June 2020

The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells

scientific article published on 30 January 2019

The distribution of the proteoglycan FORSE-1 in the developing mouse central nervous system

scientific article published on 25 November 2018

The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-κB signalling

scientific article published on 20 August 2012

The need for ethical and pedagogical frameworks for developing online media in anatomy education

scientific article published on 6 June 2016

The neurite growth inhibitory effects of soluble TNFα on developing sympathetic neurons are dependent on developmental age.

scientific article published on November 2014

The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease

scientific article published on 01 August 2020

The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment

scientific article

The spatial and temporal arrangement of the radial glial scaffold suggests a role in axon tract formation in the developing spinal cord.

scientific article published on 2 November 2012

Transplantation of novel human GDF5-expressing CHO cells is neuroprotective in models of Parkinson's disease.

scientific article published on October 2012

Ventral midbrain neural stem cells have delayed neurogenic potential in vitro

scientific article

Viral vector delivery of neurotrophic factors for Parkinson's disease therapy

scientific article published on 13 May 2015

Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation

scientific article

Zeb2: A multifunctional regulator of nervous system development.

scientific article published on 17 July 2015

List of works by Gerard O'Keeffe

28 Growth Differentiation Factor-5 (GDF-5) expression in the rat brain: developmental regulator, potential treatment?

4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells

6-Hydroxydopamine induces distinct alterations in GDF5 and GDNF mRNA expression in the rat nigrostriatal system in vivo

A Case Study in the Use of Primary Literature in the Context of Authentic Learning Pedagogy in the Undergraduate Neuroscience Classroom

A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease.

A new role for placental IL-6 signalling in determining neurodevelopmental outcome

A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: does maternal inflammation play a role?

A practical description and student perspective of the integration of radiology into lower limb musculoskeletal anatomy

Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker

Alterations in α-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons

An Attitudinal Survey of Undergraduate Neuroscience Students Regarding Their Views on the Relevance of Lectures to their Education

Anatomy education for the YouTube generation

Association between preeclampsia and autism spectrum disorder: a population-based study

Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring: A Systematic Review and Meta-analysis

Association of distinct type 1 bone morphogenetic protein receptors with different molecular pathways and survival outcomes in neuroblastoma

BMP-Smad 1/5/8 signalling in the development of the nervous system.

BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons.

Cadaveric anatomy in the future of medical education: What is the surgeons view?

Canonical BMP-Smad signalling promotes neurite growth in rat midbrain dopaminergic neurons

Class-IIa Histone Deacetylase Inhibition Promotes the Growth of Neural Processes and Protects Them Against Neurotoxic Insult

Class-Specific Histone Deacetylase Inhibitors Promote 11-Beta Hydroxysteroid Dehydrogenase Type 2 Expression in JEG-3 Cells.

Distinct alterations in motor & reward seeking behavior are dependent on the gestational age of exposure to LPS-induced maternal immune activation

Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington's disease

Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy

Effects of growth/differentiation factor 5 on the survival and morphology of embryonic rat midbrain dopaminergic neurones in vitro

Effects of intracerebral neurotrophic factor application on motor symptoms in Parkinson's disease: A systematic review and meta-analysis.

Endocytosis contributes to BMP2-induced Smad signalling and neuronal growth.

Evidence for dopaminergic axonal degeneration as an early pathological process in Parkinson's disease

Exposure of foetal neural progenitor cells to IL-1β impairs their proliferation and alters their differentiation - a role for maternal inflammation?

Exposure to Hypertensive Disorders of Pregnancy Increases the Risk of Autism Spectrum Disorder in Affected Offspring

Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease.

Expression of growth differentiation factor-5 in the developing and adult rat brain.

Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling

Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T α-synuclein.

Googling in anatomy education: Can google trends inform educators of national online search patterns of anatomical syllabi?

Hypertensive disorders of pregnancy and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis protocol.

IL-1β inhibits axonal growth of developing sympathetic neurons

Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease

LPS alters placental inflammatory and endocrine mediators and inhibits fetal neurite growth in affected offspring during late gestation

Magnesium sulphate prevents lipopolysaccharide-induced cell death in an in vitro model of the human placenta.

Maternal distress in late pregnancy alters obstetric outcomes and the expression of genes important for placental glucocorticoid signalling

Microbiota and neurodevelopmental windows: implications for brain disorders

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

Midbrain dopaminergic neurons: a review of the molecular circuitry that regulates their development.

Mild prenatal hypoxia-ischemia leads to social deficits and central and peripheral inflammation in exposed offspring

Mitogen-activated protein kinase phosphatase (MKP)-1 as a neuroprotective agent: promotion of the morphological development of midbrain dopaminergic neurons.

Modular and coordinated expression of immune system regulatory and signaling components in the developing and adult nervous system

NGF-promoted axon growth and target innervation requires GITRL-GITR signaling

Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation.

Nerve growth factor-mediated regulation of pain signalling and proposed new intervention strategies in clinical pain management

Neurotrophic factor therapy for Parkinson's disease: past, present and future

Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease.

Nociceptin/Orphanin FQ Inhibits the Survival and Axon Growth of Midbrain Dopaminergic Neurons Through a p38-MAPK Dependent Mechanism

Nuclear factor-kappaB activation via tyrosine phosphorylation of inhibitor kappaB-alpha is crucial for ciliary neurotrophic factor-promoted neurite growth from developing neurons

Peroxisomes: the neuropathological consequences of peroxisomal dysfunction in the developing brain.

Placental FKBP51 mediates a link between second trimester maternal anxiety and birthweight in female infants

Predicting infant neurodevelopmental outcomes using the placenta?

Prenatal maternal stress and risk of neurodevelopmental disorders in the offspring: a systematic review and meta-analysis

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood

Radiologist's views on anatomical knowledge amongst junior doctors and the teaching of anatomy in medical curricula

Region-specific role of growth differentiation factor-5 in the establishment of sympathetic innervation

Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region

Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region

Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor

Regulation of neurite growth by tumour necrosis superfamily member RANKL.

Roles for the TGFβ superfamily in the development and survival of midbrain dopaminergic neurons.

Romidepsin induces caspase-dependent cell death in human neuroblastoma cells

Targeting transcriptional regulators to regenerate midbrain dopaminergic axons in Parkinson's disease.

The Effect of Hypertensive Disorders of Pregnancy on the Risk of ADHD in the Offspring.

The Epigenome as a therapeutic target for Parkinson's disease.

The association between caesarean section and cognitive ability in childhood

The class II histone deacetylases as therapeutic targets for Parkinson's disease

The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells

The distribution of the proteoglycan FORSE-1 in the developing mouse central nervous system

The intracellular portion of GITR enhances NGF-promoted neurite growth through an inverse modulation of Erk and NF-κB signalling

The need for ethical and pedagogical frameworks for developing online media in anatomy education

The neurite growth inhibitory effects of soluble TNFα on developing sympathetic neurons are dependent on developmental age.

The potential of bone morphogenetic protein 2 as a neurotrophic factor for Parkinson's disease

The role of growth/differentiation factor 5 (GDF5) in the induction and survival of midbrain dopaminergic neurones: relevance to Parkinson's disease treatment