List of works - James Barrow

Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice

scientific article published on 18 May 2009

Challenges and opportunities in neuroscience research

scientific article published on 01 March 2012

Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates ⬇️

scientific article published on November 14, 2011

Classics in chemical neuroscience: diazepam (valium).

scientific article

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1

scientific article

Design and synthesis of potent and selective macrocyclic thrombin inhibitors

scientific article

Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist

scientific article published on 10 June 2008

Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors

scientific article

Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis

scientific article

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation

scientific article

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase

scientific article

Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors

scientific article

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists

scientific article published on 8 July 2010

Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels

scientific article published on 26 September 2008

Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists.

scientific article published on February 2010

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

scientific article published in February 2002

Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing

scientific article published on 01 January 2009

High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors.

scientific article

Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group

scientific article published in May 2004

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

scientific article published on 01 July 2000

In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.

scientific article published on 3 August 2010

Inhibitors of Catechol-O-Methyltransferase ⬇️

scientific article published on May 1, 2012

Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2

scientific article

Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1

scientific article

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

scientific article (publication date: 13 February 2003)

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

scientific article

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

scientific article published on 19 October 2018

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

scientific article

Positive allosteric interaction of structurally diverse T-type calcium channel antagonists.

scientific article published on 7 July 2009

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists

scientific article published on 01 September 2000

Pyridyl amides as potent inhibitors of T-type calcium channels

scientific article published on 26 January 2011

Recent advances in medicinal chemistry for treatment of sleep and wake disorders

scientific article published in January 2008

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition

scientific article published on 4 February 2010

Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones

scientific article published on 01 August 2000

Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.

scientific article published on 24 August 2010

Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328.

scientific article published on 18 April 2011

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).

scientific article published on 26 January 2015

Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics

scientific article

T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats

scientific article published on 24 November 2010

T-type calcium channels regulate cortical plasticity in-vivo. [corrected]

scientific article

Total Syntheses of Vancomycin and Eremomycin Aglycons

scientific article published on 01 October 1998

Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position

scientific article published on 01 October 2003

[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey.

scientific article published on 7 July 2011

List of works by James Barrow

Antagonism of T-type calcium channels inhibits high-fat diet-induced weight gain in mice

Challenges and opportunities in neuroscience research

Characterization of Non-Nitrocatechol Pan and Isoform Specific Catechol-O-methyltransferase Inhibitors and Substrates ⬇️

Classics in chemical neuroscience: diazepam (valium).

Design and synthesis of 2,3,5-substituted imidazolidin-4-one inhibitors of BACE-1

Design and synthesis of potent and selective macrocyclic thrombin inhibitors

Design, synthesis, and evaluation of a novel 4-aminomethyl-4-fluoropiperidine as a T-type Ca2+ channel antagonist

Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors

Discovery and Optimization of a Series of Pyrimidine-Based Phosphodiesterase 10A (PDE10A) Inhibitors through Fragment Screening, Structure-Based Design, and Parallel Synthesis

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation

Discovery and X-ray crystallographic analysis of a spiropiperidine iminohydantoin inhibitor of beta-secretase

Discovery and evaluation of potent P1 aryl heterocycle-based thrombin inhibitors

Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists

Discovery of 1,4-substituted piperidines as potent and selective inhibitors of T-type calcium channels

Discovery of 4,4-Disubstituted Quinazolin-2-ones as T-Type Calcium Channel Antagonists.

Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1).

Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing

High concentration electrophysiology-based fragment screen: discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors.

Imidazole acetic acid TAFIa inhibitors: SAR studies centered around the basic P(1)(') group

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia

In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice.

Inhibitors of Catechol-O-Methyltransferase ⬇️

Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2

Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1

Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines

Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

Positive allosteric interaction of structurally diverse T-type calcium channel antagonists.

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective alpha1a-receptor antagonists

Pyridyl amides as potent inhibitors of T-type calcium channels

Recent advances in medicinal chemistry for treatment of sleep and wake disorders

SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition

Selective alpha1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones

Short-acting T-type calcium channel antagonists significantly modify sleep architecture in rodents.

Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328.

Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).

Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics

T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats

T-type calcium channels regulate cortical plasticity in-vivo. [corrected]

Total Syntheses of Vancomycin and Eremomycin Aglycons

Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position

[18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkey.