List of works - Raffaele Riccio

2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors

scientific article published on 4 January 2016

9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain

scientific article

A New Cycloamphilectene Metabolite from the Vanuatu SpongeAxinellasp

scientific article published on 01 August 2002

Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression

scientific article published on 15 August 2009

Bio-inspired benzo[k,l]xanthene lignans: synthesis, DNA-interaction and antiproliferative properties

scientific article published on 01 May 2014

Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin.

scientific article published in August 2016

Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride.

scientific article published on 5 October 2016

Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

scientific article published on 24 July 2012

Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor.

scientific article published on May 2010

Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor.

scientific article published on 8 November 2010

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.

scientific article published on 24 May 2013

Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp.

scientific article published on 3 May 2017

Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase

scientific article published on 01 November 2018

Comparison of different theory models and basis sets in the calculation of 13C NMR chemical shifts of natural products

scientific article published on 01 October 2004

Conformationally locked calixarene-based histone deacetylase inhibitors

scientific article published on 01 November 2010

DFT/NMR integrated approach: a valid support to the total synthesis of chiral molecules

scientific article published on 01 October 2008

Design, synthesis, and biological activity of hydroxamic tertiary amines as histone deacetylase inhibitors

scientific article published on 25 January 2012

Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.

scientific article

Determination of relative configuration in organic compounds by NMR spectroscopy and computational methods.

scientific article published on 25 July 2007

Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the gamma-hydroxybutenolide scaffold.

scientific article published on 6 August 2008

Differential in gel electrophoresis (DIGE) comparative proteomic analysis of macrophages cell cultures in response to perthamide C treatment

scientific article published on 17 April 2013

Differential-frequency saturation transfer difference NMR spectroscopy allows the detection of different ligand-DNA binding modes

scientific article published on 01 December 2005

Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors

scientific article published on 23 May 2013

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches.

scientific article published on 13 October 2017

Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics

article

Discovery of new erbB4 inhibitors: Repositioning an orphan chemical library by inverse virtual screening

scientific article published on 12 April 2018

Discovery of new molecular entities able to strongly interfere with Hsp90 C-terminal domain

scientific article published on 26 January 2018

Effect of electronegative substituents and angular dependence on the heteronuclear spin-spin coupling constant 3J(C-H): an empirical prediction equation derived by density functional theory calculations.

scientific article published in March 2010

Effects of petrosaspongiolide R on the surface topology of bee venom PLA(2): a limited proteolysis and mass spectrometry analysis

scientific article

Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors

Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1).

scientific article published on 24 April 2014

Extension of the J-based configuration analysis to multiple conformer equilibria: an application to sapinofuranone A

scientific article published on 01 August 2002

Further insights on the structural aspects of PLA(2) inhibition by gamma-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M-R.

scientific article published in March 2004

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

scientific article published in January 2014

Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors

scientific article published on 20 June 2018

Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.

scientific article

Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening

scientific article published on 14 September 2016

Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors.

scientific article published on 12 October 2016

Immunomodulatory Biscembranoids and Assignment of Their Relative and Absolute Configurations: Data Set Modulation in the Density Functional Theory/Nuclear Magnetic Resonance Approach

scientific article published on 08 April 2019

In cell scalaradial interactome profiling using a bio-orthogonal clickable probe

scientific article published on 28 April 2014

Inverse Virtual Screening allows the discovery of the biological activity of natural compounds.

scientific article

Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.

scientific article

Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa

scientific article published in October 2001

Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy.

scientific article published on 14 February 2014

Metabolism in porifera. VII. Conversion of [7,7-3H2]-fucosterol into calysterol by the sponge Calyx niceaensis

scientific article published on December 15, 1977

Modulation of tau protein fibrillization by oleocanthal.

scientific article published on 18 September 2012

Molecular insights into azumamide e histone deacetylases inhibitory activity

scientific article published on 21 February 2007

Molecular modeling studies toward the structural optimization of new cyclopeptide-based HDAC inhibitors modeled on the natural product FR235222.

scientific article published on 6 August 2008

N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization

scientific article published on 04 February 2014

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

scientific article published on 07 July 2011

New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei

scientific article published on 2 April 2014

Nucleophilic cyclopropane ring opening in duocarmycin SA derivatives by methanol under acid conditions: a quantum mechanical study in the gas-phase and in solution.

scientific article published in April 2004

Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions

scientific article published on 8 November 2014

On the role of stereo-electronic effects in tuning the selectivity and rate of DNA alkylation by duocarmycins

scientific article published on 27 February 2006

PLA2-mediated catalytic activation of its inhibitor 25-acetyl-petrosaspongiolide M: serendipitous identification of a new PLA2 suicide inhibitor

scientific article published in December 2004

Plakilactones G and H from a marine sponge. Stereochemical determination of highly flexible systems by quantitative NMR-derived interproton distances combined with quantum mechanical calculations of (13)C chemical shifts

scientific article published on 30 December 2013

Quantum chemical calculations of 1J(CC) coupling constants for the stereochemical determination of organic compounds

scientific article published on 16 January 2013

Quantum mechanical calculations of NMR J coupling values in the determination of relative configuration in organic compounds

scientific article published on 01 March 2004

Quantum mechanical calculations of conformationally relevant 1H and 13C NMR chemical shifts of N-, O-, and S-substituted calixarene systems

scientific article published on 01 January 2007

Quantum mechanical calculations of conformationally relevant 1H and 13C NMR chemical shifts of calixarene systems

scientific article published on 01 December 2005

Regioselective entry to bromo-gamma-hydroxybutenolides: useful building blocks for assemblying natural product-like libraries.

scientific article

Renieramide, a Cyclic Tripeptide from the Vanuatu SpongeRenieran. sp

scientific article published on 01 March 2002

Scalaradial, a Dialdehyde-Containing Marine Metabolite That Causes an Unexpected Noncovalent PLA2 Inactivation

scientific article published on 01 September 2007

Starfish Saponins, Part 46. Steroidal Glycosides and Polyhydroxysteroids from the Starfish Culcita novaeguineae ⬇️

scientific article published on 01 September 1991

Structural Evidence of N6-Isopentenyladenosine As a New Ligand of Farnesyl Pyrophosphate Synthase

article

Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors

scientific article published on 7 January 2015

Structural basis for the design and synthesis of selective HDAC inhibitors

scientific article published on 22 April 2013

Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans

scientific article published on 16 November 2010

Structural insights into Estrogen Related Receptor-β modulation: 4-methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists.

scientific article published on 4 December 2013

Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

scientific article

Structure-activity relationship study of 16 a-thiocamptothecins: an integrated in vitro and in silico approach

scientific article published on December 2010

Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.

scientific article published on 16 February 2011

Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal

scientific article published on 04 April 2007

Synthesis, conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics

scientific article published in September 2006

Synthesis, conformational analysis, and cytotoxicity of new analogues of the natural cyclodepsipeptide jaspamide.

scientific article published in August 2004

Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide.

scientific article

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold.

scientific article

The binding mode of cladocoran A to the human group IIA phospholipase A(2).

scientific article

The inactivation mechanism of human group IIA phospholipase A(2) by Scalaradial

scientific article published on 24 September 2012

The inactivation of phospholipase A2 by scalaradial: a biomimetic study by electrospray mass spectrometry

scientific article published in January 2005

The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone

scientific article published on 01 June 2006

The molecular mechanism of human group IIA phospholipase A2 inactivation by bolinaquinone.

scientific article published in November 2009

Theonellasterone, a steroidal metabolite isolated from a Theonella sponge, protects peroxiredoxin-1 from oxidative stress reactions

scientific article

Tolaasins A--E, five new lipodepsipeptides produced by Pseudomonas tolaasii

scientific article

Virtual fragment screening identification of a novel Quinoline-5,8-dicarboxylic acid derivative as selective JMJD3 inhibitor.

scientific article published on 6 April 2018

β-Boswellic acid, a bioactive substance used in food supplements, inhibits protein synthesis by targeting the ribosomal machinery.

scientific article published on 27 July 2016

List of works by Raffaele Riccio

2,3-Dihydrobenzofuran privileged structures as new bioinspired lead compounds for the design of mPGES-1 inhibitors

9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain

A New Cycloamphilectene Metabolite from the Vanuatu SpongeAxinellasp

Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression

Bio-inspired benzo[k,l]xanthene lignans: synthesis, DNA-interaction and antiproliferative properties

Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin.

Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride.

Chemical Proteomics Reveals Heat Shock Protein 60 To Be the Main Cellular Target of the Marine Bioactive Sesterterpene Suvanine

Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor.

Chemical proteomics reveals bolinaquinone as a clathrin-mediated endocytosis inhibitor.

Chemical proteomics-driven discovery of oleocanthal as an Hsp90 inhibitor.

Chemistry and Selective Tumor Cell Growth Inhibitory Activity of Polyketides from the South China Sea Sponge Plakortis sp.

Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase

Comparison of different theory models and basis sets in the calculation of 13C NMR chemical shifts of natural products

Conformationally locked calixarene-based histone deacetylase inhibitors

DFT/NMR integrated approach: a valid support to the total synthesis of chiral molecules

Design, synthesis, and biological activity of hydroxamic tertiary amines as histone deacetylase inhibitors

Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics.

Determination of relative configuration in organic compounds by NMR spectroscopy and computational methods.

Development of a second generation of inhibitors of microsomal prostaglandin E synthase 1 expression bearing the gamma-hydroxybutenolide scaffold.

Differential in gel electrophoresis (DIGE) comparative proteomic analysis of macrophages cell cultures in response to perthamide C treatment

Differential-frequency saturation transfer difference NMR spectroscopy allows the detection of different ligand-DNA binding modes

Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors

Discovering the Biological Target of 5-epi-Sinuleptolide Using a Combination of Proteomic Approaches.

Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics

Discovery of new erbB4 inhibitors: Repositioning an orphan chemical library by inverse virtual screening

Discovery of new molecular entities able to strongly interfere with Hsp90 C-terminal domain

Effect of electronegative substituents and angular dependence on the heteronuclear spin-spin coupling constant 3J(C-H): an empirical prediction equation derived by density functional theory calculations.

Effects of petrosaspongiolide R on the surface topology of bee venom PLA(2): a limited proteolysis and mass spectrometry analysis

Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors

Exploration of the dihydropyrimidine scaffold for the development of new potential anti-inflammatory agents blocking prostaglandin E₂ synthase-1 enzyme (mPGES-1).

Extension of the J-based configuration analysis to multiple conformer equilibria: an application to sapinofuranone A

Further insights on the structural aspects of PLA(2) inhibition by gamma-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M-R.

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

Identification by Inverse Virtual Screening of magnolol-based scaffold as new tankyrase-2 inhibitors

Identification of new γ-hydroxybutenolides that preferentially inhibit the activity of mPGES-1.

Identification of novel microsomal prostaglandin E2 synthase-1 (mPGES-1) lead inhibitors from Fragment Virtual Screening

Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors.

Immunomodulatory Biscembranoids and Assignment of Their Relative and Absolute Configurations: Data Set Modulation in the Density Functional Theory/Nuclear Magnetic Resonance Approach

In cell scalaradial interactome profiling using a bio-orthogonal clickable probe

Inverse Virtual Screening allows the discovery of the biological activity of natural compounds.

Inverse virtual screening of antitumor targets: pilot study on a small database of natural bioactive compounds.

Makaluvamine P, a new cytotoxic pyrroloiminoquinone from Zyzzya cf. fuliginosa

Mechanistic insights on petrosaspongiolide M inhibitory effects on immunoproteasome and autophagy.

Metabolism in porifera. VII. Conversion of [7,7-3H2]-fucosterol into calysterol by the sponge Calyx niceaensis

Modulation of tau protein fibrillization by oleocanthal.

Molecular insights into azumamide e histone deacetylases inhibitory activity

Molecular modeling studies toward the structural optimization of new cyclopeptide-based HDAC inhibitors modeled on the natural product FR235222.

N-Formyl-7-amino-11-cycloamphilectene, a marine sponge metabolite, binds to tubulin and modulates microtubule depolymerization

New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component

New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei

Nucleophilic cyclopropane ring opening in duocarmycin SA derivatives by methanol under acid conditions: a quantum mechanical study in the gas-phase and in solution.

Oligosaccharidic fractions derived from Triticum vulgare extract accelerate tissutal repairing processes in in vitro and in vivo models of skin lesions

On the role of stereo-electronic effects in tuning the selectivity and rate of DNA alkylation by duocarmycins

PLA2-mediated catalytic activation of its inhibitor 25-acetyl-petrosaspongiolide M: serendipitous identification of a new PLA2 suicide inhibitor

Plakilactones G and H from a marine sponge. Stereochemical determination of highly flexible systems by quantitative NMR-derived interproton distances combined with quantum mechanical calculations of (13)C chemical shifts

Quantum chemical calculations of 1J(CC) coupling constants for the stereochemical determination of organic compounds

Quantum mechanical calculations of NMR J coupling values in the determination of relative configuration in organic compounds

Quantum mechanical calculations of conformationally relevant 1H and 13C NMR chemical shifts of N-, O-, and S-substituted calixarene systems

Quantum mechanical calculations of conformationally relevant 1H and 13C NMR chemical shifts of calixarene systems

Regioselective entry to bromo-gamma-hydroxybutenolides: useful building blocks for assemblying natural product-like libraries.

Renieramide, a Cyclic Tripeptide from the Vanuatu SpongeRenieran. sp

Scalaradial, a Dialdehyde-Containing Marine Metabolite That Causes an Unexpected Noncovalent PLA2 Inactivation

Starfish Saponins, Part 46. Steroidal Glycosides and Polyhydroxysteroids from the Starfish Culcita novaeguineae ⬇️

Structural Evidence of N6-Isopentenyladenosine As a New Ligand of Farnesyl Pyrophosphate Synthase

Structural Insights for the Optimization of Dihydropyrimidin-2(1H)-one Based mPGES-1 Inhibitors

Structural basis for the design and synthesis of selective HDAC inhibitors

Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans

Structural insights into Estrogen Related Receptor-β modulation: 4-methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists.

Structure-Based Design of Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) Inhibitors using a Virtual Fragment Growing Optimization Scheme

Structure-activity relationship study of 16 a-thiocamptothecins: an integrated in vitro and in silico approach

Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.

Synthesis and pharmacological evaluation of a selected library of new potential anti-inflammatory agents bearing the gamma-hydroxybutenolide scaffold: a new class of inhibitors of prostanoid production through the selective modulation of microsomal

Synthesis, conformational analysis and CB1 binding affinity of hairpin-like anandamide pseudopeptide mimetics

Synthesis, conformational analysis, and cytotoxicity of new analogues of the natural cyclodepsipeptide jaspamide.

Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide.

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold.

The binding mode of cladocoran A to the human group IIA phospholipase A(2).

The inactivation mechanism of human group IIA phospholipase A(2) by Scalaradial