List of works - Wen-hsing Lin

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

scientific article

3D-QSAR-assisted drug design: identification of a potent quinazoline-based Aurora kinase inhibitor.

scientific article published on 22 November 2012

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors

scientific article

A novel aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment

scientific article published on 29 April 2013

Antiviral drug discovery against SARS-CoV.

scientific article

Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population.

scientific article

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold

scientific article

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

scientific article

BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML

scientific article published on 20 December 2011

BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

scientific article

Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B

scientific article

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

scientific article

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

scientific article published on 6 April 2013

Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes

scientific article (publication date: 15 August 2001)

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors ⬇️

scientific article published on May 10, 2013

SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes

scientific article

Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists

scientific article published on October 2010

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity

scientific article

Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells

scientific article published on 22 March 2011

List of works by Wen-hsing Lin

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

3D-QSAR-assisted drug design: identification of a potent quinazoline-based Aurora kinase inhibitor.

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors

A novel aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment

Antiviral drug discovery against SARS-CoV.

Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population.

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML

BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors ⬇️

SLC2A10 genetic polymorphism predicts development of peripheral arterial disease in patients with type 2 diabetes. SLC2A10 and PAD in type 2 diabetes

Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity

Suppression of Stat3 activity sensitizes gefitinib-resistant non small cell lung cancer cells