List of works - Jorg Tatzelt

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

scientific article published in November 1997

A protein quality control pathway regulated by linear ubiquitination

scientific article published on 18 March 2019

A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds.

scientific article

Aberrant Folding of Pathogenic Parkin Mutants

scientific article published in Journal of Biological Chemistry

Abnormalities in stress proteins in prion diseases

scientific article

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

scientific article

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)

scientific article

Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.

scientific article published on 17 May 2006

Cationic Lipopolyamines Induce Degradation of PrPSc in Scrapie-Infected Mouse Neuroblastoma Cells

article published in 2000

Cellular prion protein mediates toxic signaling of amyloid beta

scientific article

Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.

scientific article published on 14 December 2010

Conserved stress-protective activity between prion protein and Shadoo

scientific article published on 21 January 2011

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

scientific article published on 3 December 2015

Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation

scientific article

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

scientific article

Dimerization of the cellular prion protein inhibits propagation of scrapie prions.

scientific article published on 10 April 2018

Folding and misfolding of the prion protein in the secretory pathway

scientific article

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

scientific article published on 04 January 2019

Geldanamycin restores a defective heat shock response in vivo

scientific article

Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.

scientific article

Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseases

scientific article published in February 2018

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

scientific article published on 12 September 2003

Inhibition of complex glycosylation increases the formation of PrPsc

scientific article published in May 2003

Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

scientific article

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

scientific article

Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation

scientific article published on June 2004

Molecular basis of cerebral neurodegeneration in prion diseases.

scientific article published on February 2007

Neuroprotective and neurotoxic signaling by the prion protein

scientific article published on January 2011

Observing fibrillar assemblies on scrapie-infected cells

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration

scientific article

Parkin is protective against proteotoxic stress in a transgenic zebrafish model

scientific article

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

scientific article

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

scientific article

Pathogenic mutations inactivate parkin by distinct mechanisms.

scientific article

Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.

scientific article

Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain

scientific article published on 8 July 2003

Prion disease: a tale of folds and strains

scientific article published on May 2013

Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system

scientific article published in December 1997

Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor

scientific article published on 9 January 2006

Prion proteins

scientific article published on 01 January 2011

Propagation of prion strains through specific conformers of the prion protein

scientific article published on December 1997

Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing

scientific article published on 01 October 2010

Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein

scientific article published in August 1996

SecY-mediated quality control prevents the translocation of non-gated porins

scientific article published on 01 October 2020

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

scientific article published on 27 April 2016

Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes

scientific article published in September 2007

Stress-protective signalling of prion protein is corrupted by scrapie prions

scientific article

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.

scientific article published on 6 April 2018

Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

scientific article published on 12 March 2013

Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations

scientific article

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

scientific article published on 8 December 2017

Synthesis of a GPI anchor module suitable for protein post-translational modification

scientific article published on 01 January 2010

The C-terminal Globular Domain of the Prion Protein Is Necessary and Sufficient for Import into the Endoplasmic Reticulum

scientific article published in Journal of Biological Chemistry

The Cellular Prion Protein: A Player in Immunological Quiescence

scientific article

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

scientific article

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.

scientific article

The RAB GTPase RAB18 modulates macroautophagy and proteostasis

scientific article published on 22 March 2017

The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins

scientific article published on 30 October 2017

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

scientific article published on 25 March 2011

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.

scientific article published on 31 October 2012

The mechanism of adenovirus DNA integration: studies in a cell-free system.

scientific article published on January 1995

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein

scientific article

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

scientific article published on 04 February 2020

The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose.

scientific article published in November 2005

The prion protein in neuroimmune crosstalk

scientific article published on 15 November 2018

The prion protein: friend and foe

scientific article published on 18 September 2009

The role of chaperones in Parkinson's disease and prion diseases.

scientific article

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

scientific article published on 05 March 2019

The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites

scientific article published in November 2004

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

scientific article published on January 2008

The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum

scientific article published on 26 March 2013

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

scientific article published on 04 May 2020

alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum

scientific article

List of works by Jorg Tatzelt

A hypothalamic neuronal cell line persistently infected with scrapie prions exhibits apoptosis.

A protein quality control pathway regulated by linear ubiquitination

A sensitive filter retention assay for the detection of PrP(Sc) and the screening of anti-prion compounds.

Aberrant Folding of Pathogenic Parkin Mutants

Abnormalities in stress proteins in prion diseases

Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.

Anti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)

Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.

Cationic Lipopolyamines Induce Degradation of PrPSc in Scrapie-Infected Mouse Neuroblastoma Cells

Cellular prion protein mediates toxic signaling of amyloid beta

Conditional modulation of membrane protein expression in cultured cells mediated by prion protein recognition of short phosphorothioate oligodeoxynucleotides.

Conserved stress-protective activity between prion protein and Shadoo

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

Determinants of the in vivo folding of the prion protein. A bipartite function of helix 1 in folding and aggregation

Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells

Dimerization of the cellular prion protein inhibits propagation of scrapie prions.

Folding and misfolding of the prion protein in the secretory pathway

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice

Geldanamycin restores a defective heat shock response in vivo

Green tea extracts interfere with the stress-protective activity of PrP and the formation of PrP.

Impaired transport of intrinsically disordered proteins through the Sec61 and SecY translocon; implications for prion diseases

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

Inhibition of complex glycosylation increases the formation of PrPsc

Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease

Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation

Misfolding of the prion protein at the plasma membrane induces endocytosis, intracellular retention and degradation

Molecular basis of cerebral neurodegeneration in prion diseases.

Neuroprotective and neurotoxic signaling by the prion protein

Observing fibrillar assemblies on scrapie-infected cells

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration

Parkin is protective against proteotoxic stress in a transgenic zebrafish model

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling

Pathogenic mutations inactivate parkin by distinct mechanisms.

Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor.

Post-translational import of the prion protein into the endoplasmic reticulum interferes with cell viability: a critical role for the putative transmembrane domain

Prion disease: a tale of folds and strains

Prion protein expression in Chinese hamster ovary cells using a glutamine synthetase selection and amplification system

Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor

Prion proteins

Propagation of prion strains through specific conformers of the prion protein

Protein immobilization on liposomes and lipid-coated nanoparticles by protein trans-splicing

Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein

SecY-mediated quality control prevents the translocation of non-gated porins

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

Semisynthetic murine prion protein equipped with a GPI anchor mimic incorporates into cellular membranes

Stress-protective signalling of prion protein is corrupted by scrapie prions

Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.

Structural features within the nascent chain regulate alternative targeting of secretory proteins to mitochondria

Structural instability of the prion protein upon M205S/R mutations revealed by molecular dynamics simulations

Substitutions of PrP N-terminal histidine residues modulate scrapie disease pathogenesis and incubation time in transgenic mice.

Synthesis of a GPI anchor module suitable for protein post-translational modification

The C-terminal Globular Domain of the Prion Protein Is Necessary and Sufficient for Import into the Endoplasmic Reticulum

The Cellular Prion Protein: A Player in Immunological Quiescence

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus.

The RAB GTPase RAB18 modulates macroautophagy and proteostasis

The Sec61/SecY complex is inherently deficient in translocating intrinsically disordered proteins

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.

The mechanism of adenovirus DNA integration: studies in a cell-free system.

The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein

The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

The polysaccharide scaffold of PrP 27-30 is a common compound of natural prions and consists of alpha-linked polyglucose.

The prion protein in neuroimmune crosstalk

The prion protein: friend and foe

The role of chaperones in Parkinson's disease and prion diseases.

The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61 channel gating

The structural transition of the prion protein into its pathogenic conformation is induced by unmasking hydrophobic sites

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

The α-helical structure of prodomains promotes translocation of intrinsically disordered neuropeptide hormones into the endoplasmic reticulum

Transgenic Overexpression of the Disordered Prion Protein N1 Fragment in Mice Does Not Protect Against Neurodegenerative Diseases Due to Impaired ER Translocation

alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulum