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List of works by Peter W. Lewis

A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas

scientific article

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

scientific article

ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons

scientific article

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

scientific article published in Nature Communications

Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A.

scientific article

Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation

scientific article published on 20 February 2019

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition

scientific article

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

scientific article

Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.

scientific article

Distinct factors control histone variant H3.3 localization at specific genomic regions

scientific article

Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex

scientific article

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

scientific article (publication date: May 2014)

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells

scientific article

H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone

scientific article published on 23 September 2020

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

scientific article published on 19 March 2019

Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase

scientific article published on 09 April 2019

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

scientific article published on 16 October 2020

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

scientific article published on May 2016

Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3.

scientific article published on 18 October 2016

Histone variants in metazoan development

scientific article

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

scientific article

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

scientific article published on 9 January 2017

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

scientific article

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

scientific article

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors

scientific article

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas

scientific article published on November 2016

New Epigenetic Drivers of Cancers

scientific article published in Science

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism

scientific article published on 13 May 2019

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

scientific article published on 01 May 2019

Poisoning the "histone code" in pediatric gliomagenesis

scientific article published on 13 September 2013

Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers

scientific article published on 23 August 2018

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.

scientific article published on 16 May 2016

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells

scientific article published on 02 February 2019

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas

scientific article

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2

scientific article

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.

scientific article published on 30 October 2017

Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin

scientific article

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

scientific article

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