List of works - An Zwijsen

A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components

scientific article published on 20 August 2008

A conserved role for non-neural ectoderm cells in early neural development

scientific article published in October 2014

A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression.

scientific article published on 13 December 2012

Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus

scientific journal article

Amnion formation in the mouse embryo: the single amniochorionic fold model.

scientific article

Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling

scholarly article by Mariya P Dobreva published in July 2018

Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion

scientific article published on September 2012

Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis

scientific article published on 26 July 2018

Author Correction: The epicardium obscures interpretations on endothelial-to-mesenchymal transition in the mouse atrioventricular canal explant assay

scientific article published on 31 March 2020

BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.

scientific article

BMP signaling in vascular biology and dysfunction

scientific article published on 15 December 2015

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

scientific article

BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

scientific article

BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development

scientific article published on 23 March 2020

Bone Morphogenetic Proteins in Vascular Homeostasis and Disease

scientific article published on 27 March 2017

Cadherin-dependent cell aggregation is affected by decapeptide derived from rat extracellular super-oxide dismutase.

scientific article published on April 1995

Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue

scientific journal article

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice

scientific article

Cyclic AMP-induced differentiation increases the synthesis of extracellular superoxide dismutase in rat C6 glioma.

scientific article

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

scientific article

EGFL7 Mediates BMP9-Induced Sprouting Angiogenesis of Endothelial Cells Derived from Human Embryonic Stem Cells.

scientific article published on 30 May 2019

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

scientific article

Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response

scientific article published on 21 September 2015

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

scientific article (publication date: December 2000)

Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap

scientific article

Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis

article

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate

scientific article published on 15 April 2009

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

scientific article published on October 2011

Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex

scientific article

Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse

scientific article

Functional redundancy of extracellular matrix protein 1 in epidermal differentiation.

scientific article

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival

scientific article published on 19 June 2008

Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse

scientific article published in September 2003

Identification of two distinct functions for TGF-beta in early mouse development

scientific journal article

Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis

scientific journal article

Keratin filaments mediate the expansion of extra‐embryonic membranes in the post‐gastrulation mouse embryo

Lineage-specific functions of TET1 in the postimplantation mouse embryo.

scientific article

Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis.

scientific article

Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development

scientific journal article

Mouse embryonic stem cells with aberrant transforming growth factor β signalling exhibit impaired differentiation in vitro and in vivo ⬇️

scientific article published on July 1, 1998

New intracellular components of bone morphogenetic protein/Smad signaling cascades

scientific article

On the origin of amniotic stem cells: of mice and men.

scientific article published on January 2010

Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome

scientific article published on 26 July 2006

PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors

scientific article published on 05 January 2017

Periostin as a biomarker of the amniotic membrane.

scientific article

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

scientific journal article

Real time monitoring of BMP Smads transcriptional activity during mouse development

scientific article published in July 2008

Robustness in angiogenesis: notch and BMP shaping waves

scientific article published on 30 December 2012

Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence

scientific article published on 21 July 2017

Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10

scientific article

Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development

scientific article published on 26 January 2011

Smad1/5 and Smad4 expression are important for osteoclast differentiation

scientific article published on July 2015

Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice

scientific article published on 24 April 2017

Smad1/5/8 are myogenic regulators of murine and human mesoangioblasts

scientific article

Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels

scientific article published on 3 August 2006

Smad5 is dispensable for adult murine hematopoiesis

scientific article published on 8 August 2006

Smad5 is essential for left-right asymmetry in mice.

scientific article published in March 2000

Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades

scientific article published on 23 February 2012

Synaptopodin and 4 novel genes identified in primary sensory neurons

scientific article published in September 2005

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

scientific article

The epicardium obscures interpretations on endothelial-to-mesenchymal transition in the mouse atrioventricular canal explant assay.

scientific article published on 16 March 2018

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation

scientific article published on 03 September 2009

Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly

scientific article published on 11 April 2016

Transforming Growth Factor type beta and Smad family signaling in stem cell function

scientific article published on October 2009

Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo.

scientific article

Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

scientific article published on 13 June 2016

List of works by An Zwijsen

A broken heart: a stretch too far: an overview of mouse models with mutations in stretch-sensor components

A conserved role for non-neural ectoderm cells in early neural development

A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-α4 expression.

Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus

Amnion formation in the mouse embryo: the single amniochorionic fold model.

Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling

Antagonism of Nodal signaling by BMP/Smad5 prevents ectopic primitive streak formation in the mouse amnion

Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis

Author Correction: The epicardium obscures interpretations on endothelial-to-mesenchymal transition in the mouse atrioventricular canal explant assay

BMP receptor-activated Smads confer diverse functions during the development of the dorsal spinal cord.

BMP signaling in vascular biology and dysfunction

BMP-SMAD Signaling Regulates Lineage Priming, but Is Dispensable for Self-Renewal in Mouse Embryonic Stem Cells

BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks

BMP-SMAD1/5 Signaling Regulates Retinal Vascular Development

Bone Morphogenetic Proteins in Vascular Homeostasis and Disease

Cadherin-dependent cell aggregation is affected by decapeptide derived from rat extracellular super-oxide dismutase.

Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue

Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice

Cyclic AMP-induced differentiation increases the synthesis of extracellular superoxide dismutase in rat C6 glioma.

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

EGFL7 Mediates BMP9-Induced Sprouting Angiogenesis of Endothelial Cells Derived from Human Embryonic Stem Cells.

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response

Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing

Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap

Expression of the inhibitory Smad7 in early mouse development and upregulation during embryonic vasculogenesis

FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex

Functional redundancy of TGF-beta family type I receptors and receptor-Smads in mediating anti-Mullerian hormone-induced Mullerian duct regression in the mouse

Functional redundancy of extracellular matrix protein 1 in epidermal differentiation.

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival

Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse

Identification of two distinct functions for TGF-beta in early mouse development

Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis

Keratin filaments mediate the expansion of extra‐embryonic membranes in the post‐gastrulation mouse embryo

Lineage-specific functions of TET1 in the postimplantation mouse embryo.

Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis.

Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development

Mouse embryonic stem cells with aberrant transforming growth factor β signalling exhibit impaired differentiation in vitro and in vivo ⬇️

New intracellular components of bone morphogenetic protein/Smad signaling cascades

On the origin of amniotic stem cells: of mice and men.

Ozzy, a Jag1 vestibular mouse mutant, displays characteristics of Alagille syndrome

PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors

Periostin as a biomarker of the amniotic membrane.

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Real time monitoring of BMP Smads transcriptional activity during mouse development

Robustness in angiogenesis: notch and BMP shaping waves

Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence

Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10

Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development

Smad1/5 and Smad4 expression are important for osteoclast differentiation

Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice

Smad1/5/8 are myogenic regulators of murine and human mesoangioblasts

Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels

Smad5 is dispensable for adult murine hematopoiesis

Smad5 is essential for left-right asymmetry in mice.

Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades

Synaptopodin and 4 novel genes identified in primary sensory neurons

The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways

The epicardium obscures interpretations on endothelial-to-mesenchymal transition in the mouse atrioventricular canal explant assay.

The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation

Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly

Transforming Growth Factor type beta and Smad family signaling in stem cell function

Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo.

Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination