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List of works by José A. Esté

2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies

scientific article

5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile

scientific article published on 17 July 2008

A Combination of Molecular Dynamics and Docking Calculations to Explore the Binding Mode of ADS-J1, a Polyanionic Compound Endowed with Anti-HIV-1 Activity

article

A Versatile Route to C-6 Arylmethyl-FunctionalizedS-DABO and Related Analogues

scientific article published on 11 July 2007

A bacteriophage lambda-based genetic screen for characterization of the activity and phenotype of the human immunodeficiency virus type 1 protease

scientific article

A clathrin-dynamin-dependent endocytic pathway for the uptake of HIV-1 by direct T cell-T cell transmission

scientific article published on 03 July 2008

A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs

scientific article

ADAR1 affects HCV infection by modulating innate immune response

scientific article published in 2018

ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation

scientific article

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

scientific article published in January 1998

Acetylcholinesterase-inhibiting alkaloids from Zephyranthes concolor.

scientific article

Ajoene [(e,z)-4,5,9-trithiadodeca-1, 6, 11-triene 9 oxide] does not exhibit antiviral activity at subtoxic concentrations ⬇️

scientific article published on 01 January 1998

Analysis of chemokine and cytokine expression in patients with HIV and GB virus type C coinfection

scientific article published in May 2005

Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.

scientific article published on 8 January 2008

Anti-HIV-1 activity of enfuvirtide (T-20) by inhibition of bystander cell death.

scientific article published in April 2003

Anti-human immunodeficiency virus activity of novel aminoglycoside-arginine conjugates at early stages of infection

scientific article

Anti-human immunodeficiency virus type 1 (HIV-1) activity of lectins from Narcissus species.

scientific article published on February 2003

Antiretroviral agents effectively block HIV replication after cell-to-cell transfer

scientific article

Antiviral Research - 15th International Conference. 17-21 March 2002, Prague, Czech Republic

scientific article published in May 2002

Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.

scientific article published on March 1996

Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases.

scientific article

Applications of 3-aminolactams: design, synthesis, and biological evaluation of a library of potential dimerisation inhibitors of HIV1-protease

scientific article

BMS-663068, a safe and effective HIV-1 attachment inhibitor.

scientific article published on 2 September 2015

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4 ⬇️

scientific article published on August 1, 1997

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

scientific article published in Nature Communications

CD4(+) and CD8(+) T cell death during human immunodeficiency virus infection in vitro

scientific article published in July 2001

CXCR4 and SDF-1 expression in B-cell chronic lymphocytic leukemia and stage of the disease

scientific article published on 29 May 2003

Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages

scientific article

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

scientific article

Cell type-dependent effect of sodium valproate on human immunodeficiency virus type 1 replication in vitro.

scientific article published on January 1997

Cell-Surface-Expressed HIV-1 Envelope Induces the Death of CD4 T Cells during GP41-Mediated Hemifusion-like Events

scientific article published on 01 January 2003

Characterization of the influence of mediator complex in HIV-1 transcription

scientific article

Chemokine and chemokine receptor expression after combined anti-HIV-1 interleukin-2 therapy

article

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents.

scientific article published on 19 June 2017

Compensatory mutations rescue the virus replicative capacity of VIRIP-resistant HIV-1.

scientific article

Computational Studies Identifying Entry Inhibitor Scaffolds Targeting the Phe 43 Cavity of HIV‐1 gp120 ⬇️

scientific article published on February 12, 2013

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

scientific article

Design, synthesis and biological evaluation of pyrido[2,3-d]pyrimidin-7-(8H)-ones as HCV inhibitors

scientific article

Development of resistance to VIR-353 with cross-resistance to the natural HIV-1 entry virus inhibitory peptide (VIRIP).

scientific article

Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level

scientific article published on 25 March 2011

Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5.

scientific article

Differential antiviral activity of derivatized dextrans

scientific article

Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.

scientific article

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants

scientific article

Discovery of novel non-cyclam polynitrogenated CXCR4 coreceptor inhibitors

scientific article

Diverse combinatorial design, synthesis and in vitro evaluation of new HEPT analogues as potential non-nucleoside HIV-1 reverse transcription inhibitors

scientific article

Effect of polyanion-resistance on HIV-1 infection.

scientific article published on August 2004

Effect of α-Methoxy Substitution on the Anti-HIV Activity of Dihydropyrimidin-4(3 H)-ones

scientific article published on 20 December 2018

Evaluation of the anti-HIV activity of natalizumab, an antibody against integrin alpha4.

scientific article

Evaluation of the anti-HIV activity of statins

scientific article published in October 2005

Evaluation of the putative role of C-C chemokines as protective factors of HIV-1 infection in seronegative hemophiliacs exposed to contaminated hemoderivatives

scientific article published in April 2000

Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes

scientific article

Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.

scientific article

HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection

scientific article published on 5 April 2009

HIV entry inhibitors.

scientific article

HIV-1 infection andCCR5Δ32homozygosis

article

HIV-1 resistance to the anti-HIV activity of a shRNA targeting a dual-coding region

scientific article published on 18 December 2007

HIV-1 resistance to the gp41-dependent fusion inhibitor C-34.

scientific article

HIV-resistance to viral entry inhibitors.

scientific article published on January 2004

HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.

scientific article published on 28 June 2012

Highlights of the 30th International Conference on Antiviral Research

scientific article published on 31 July 2017

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents

scientific article published on 26 April 2016

Identification of Hck inhibitors as hits for the development of antileukemia and anti-HIV agents

scientific article

Immunological and virological study of enfuvirtide-treated HIV-positive patients

scientific article

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

scientific article published on 25 July 2014

Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 24 November 2014

Induction of interleukins IL-6 and IL-8 by siRNA.

scientific article published on January 2007

Inhibition of HIV type 1 Tat-mediated trans-activation by oncostatin M in HLtat cells.

scientific article published on November 1995

Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein

scientific article

Inhibition of human immunodeficiency virus type 1 infection in macrophages by an alpha-v integrin blocking antibody

scientific article

Insights from host genomics into HIV infection and disease: Identification of host targets for drug development

scientific article published on 29 September 2013

Molecular characterization of human immunodeficiency virus type 1 isolates from Venezuela.

scientific article

Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients

scientific article published on 01 May 2005

New indolylarylsulfones as highly potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article published on 12 April 2014

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors

scientific article

Nitrogen positional scanning in tetramines active against HIV-1 as potential CXCR4 inhibitors.

scientific article published on 21 December 2015

Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells

scientific article published on 29 August 2012

Novel monocyclam derivatives as HIV entry inhibitors: Design, synthesis, anti-HIV evaluation, and their interaction with the CXCR4 co-receptor.

scientific article

Nucleotide embargo by SAMHD1: A strategy to block retroviral infection ⬇️

scientific article published on December 21, 2012

Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

scientific article published on September 2014

Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo

scientific article published on February 2013

Preferential attachment of HIV particles to activated and CD45RO+CD4+ T cells

scientific article published in January 2002

Purifying selection of CCR5-tropic human immunodeficiency virus type 1 variants in AIDS subjects that have developed syncytium-inducing, CXCR4-tropic viruses.

scientific article published on May 2006

R5 HIV gp120-mediated cellular contacts induce the death of single CCR5-expressing CD4 T cells by a gp41-dependent mechanism

article

RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages

scientific article published on 17 October 2017

RNA interference as a tool for target validation

scientific article published on October 2004

RNA interference of HIV replication

scientific article

Rare LEDGF/p75 genetic variants in white long-term nonprogressor HIV+ individuals.

scientific article published in February 2012

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

article

Retroviruses and Opportunistic Infections--Tenth Conference. 10-14 February 2003, Boston, MA, USA

scientific article published on 01 April 2003

Retroviruses and opportunistic infections - ninth conference. New antiviral agents. 24-28 February, Seattle, WA, USA

scientific article published on 01 April 2002

Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.

scientific article

SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors

scientific article

SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction.

scientific article published on 10 September 2015

Sch-351125 and Sch-350634. Schering-Plough.

scientific article

Search for alpha-glucosidase inhibitors: new N-substituted valienamine and conduramine F-1 derivatives

scientific article published on 22 June 2006

Secretion of interferon-gamma by human macrophages demonstrated at the single-cell level after costimulation with interleukin (IL)-12 plus IL-18

scientific article published on 28 August 2008

Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope

scientific article

Skewed expression and up-regulation of the IL-12 and IL-18 receptors in resting and activated CD4 T cells from HIV-1-infected patients

scientific article published on 02 April 2007

Slow-, tight-binding HIV-1 reverse transcriptase non-nucleoside inhibitors highly active against drug-resistant mutants

scientific article published on 01 April 2007

Stromal-cell-derived factor 1 prevents the emergence of the syncytium-inducing phenotype of HIV-1 in vivo

article

Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants

scientific article published in September 2008

Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication

article

Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains

scientific article

Synthesis, Biological Activity, and ADME Properties of Novel S-DABOs/N-DABOs as HIV Reverse Transcriptase Inhibitors

article

Targeting HIV-1 RNase H: N'-(2-Hydroxy-benzylidene)-3,4,5-Trihydroxybenzoylhydrazone as Selective Inhibitor Active against NNRTIs-Resistant Variants

scientific article published on 06 July 2020

Targeting a host element as a strategy to block HIV replication: is it nice to fool with Mother Nature?

scientific article published in March 2009

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

scientific article

The Magnitude of Interferon-γ Responses to Human Cytomegalovirus Is Predictive for HIV-1 Disease Progression

article

The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection

scientific article

The implication of the chemokine receptor CXCR4 in HIV-1 envelope protein-induced apoptosis is independent of the G protein-mediated signalling

article

The thioacetate-ω(γ-lactam carboxamide) HDAC inhibitor ST7612AA1 as HIV-1 latency reactivation agent

scientific article published on 5 September 2015

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

scientific article published on 22 June 2011

Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies

scientific article

Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells

scientific article

Treatment of monocytes with interleukin (IL)-12 plus IL-18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10.

scientific article

Use of N-methylpiperazine for the preparation of piperazine-based unsymmetrical bis-ureas as anti-HIV agents.

scientific article

Virus entry as a target for anti-HIV intervention

scientific article (publication date: September 2003)

ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression

scientific article

Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration

scientific article

p21 regulates the HIV-1 restriction factor SAMHD1.

scientific article published on 7 March 2014

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