List of works - Clay F. Semenkovich

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

scientific article published in May 2005

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

scientific article

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes

scientific article published in February 2005

ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis

scientific article published on 4 June 2015

Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse

scientific article published in October 2007

Acute ether lipid deficiency affects neutrophil biology in mice

scientific article published on 01 May 2015

Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk

scientific article published on 25 September 2003

Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models.

scientific article published on October 2008

American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome

scientific article

Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis

scientific article

An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension

scientific article published on February 2007

Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

scientific article

Autophagy links inflammasomes to atherosclerotic progression.

scientific article published on 20 March 2012

Bone weighs in on obesity

scientific article published on August 2007

Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.

scientific article published in September 2007

COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity.

scientific article published in May 1995

Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.

scientific article

De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination.

scientific article published on 6 February 2018

De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation.

scientific article

Deletion of Tis7 Protects Mice from High-Fat Diet-Induced Weight Gain and Blunts the Intestinal Adaptive Response Postresection ⬇️

scientific article published on September 22, 2010

Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice

scientific article published on 6 July 2003

Diet-dependent genetic and genomic imprinting effects on obesity in mice.

scientific article published on 10 June 2010

Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice

scientific article published on 01 November 1998

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

scientific article published on 01 July 2019

Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism

scientific article published on 01 December 1995

FASN-dependent de novo lipogenesis is required for brain development

scientific article published in 2022

Fast predators or fast food, the fit still survive

scientific article published in January 2006

Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?

scientific article published on 8 October 2011

Fatty acid synthase modulates homeostatic responses to myocardial stress.

scientific article

Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2.

scientific article published on February 2012

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

scientific article published on 2 November 2016

Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression

scientific article published on 31 December 2020

Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity.

scientific article

Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet-Induced Diabetic Retinopathy

scientific article published on 06 January 2016

Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations.

scientific article

Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains.

scientific article

Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model

scientific article

Getting away from glucose: stop sugarcoating diabetes

scientific article

Grb2 is required for atherosclerotic lesion formation

scientific article published on 15 March 2007

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Gut microbiota from twins discordant for obesity modulate metabolism in mice

scientific article (publication date: 6 September 2013)

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

scientific article

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

scientific article published on 14 October 2015

Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation

scientific article

Increased low density lipoprotein receptor expression mediated through the insulin-like growth factor-I receptor in cultured fibroblasts

scientific article published on 01 July 1994

Induction of adenosine 3',5'-monophosphate-dependent protein kinase subunits during adipogenesis in vitro

scientific article published in November 1988

Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity

scientific article

Insulin Resistance and a Long, Strange Trip.

scientific article published on 17 February 2016

Insulin resistance and atherosclerosis

scientific article published on 01 September 2008

Insulin-regulated protein palmitoylation impacts endothelial cell function.

scientific article published on 19 December 2013

Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter ⬇️

scientific article published on January 1, 2011

Lysosomal dysfunction results in altered energy balance

scientific article published on 2 October 2007

Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice

scientific article

Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains

scientific article published on 16 May 2005

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

scientific article

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

scientific article published on 2 December 2012

Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet

scientific article

Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.

scientific article

Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking

scientific article

Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII.

scientific article published in April 2004

Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα.

scientific article published on 13 April 2013

Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities

scientific journal article

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

scientific article

PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans

scientific article

PPARalpha: savior or savage?

scientific article published on 01 December 2005

Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion

scientific article published on 6 January 2005

Parent-of-origin effects propagate through networks to shape metabolic traits

scientific article published on 31 March 2022

Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.

scientific article

Peroxisome proliferator activated receptor-δ: the middle child vies for attention

scientific article published on 01 January 2014

Peroxisomes: a nexus for lipid metabolism and cellular signaling.

scientific article published on 06 February 2014

Plasma lipids in patients with type I diabetes mellitus. Influence of race, gender, and plasma glucose control: lipids do not correlate with glucose control in black women

scientific article published in January 1989

Quantitative trait loci affecting liver fat content in mice.

scientific article

Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains

scientific article published in December 2004

Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans

scientific article published on 01 February 2001

Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease.

scientific article published in December 2007

Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells.

scientific article

Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice

scientific article

Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase

scientific article published on 30 August 2007

Satellite glial cells promote regenerative growth in sensory neurons

scientific article published on 29 September 2020

Short-term interruption of training affects both fasting and post-prandial lipoproteins.

scientific article published on August 1992

Skeletal Muscle Phospholipid Metabolism Regulates Insulin Sensitivity and Contractile Function.

scientific article published on 28 October 2015

Skeletal muscle lipid flux: running water carries no poison

scientific article published on 10 May 2011

Skeletal muscle overexpression of nuclear respiratory factor 1 increases glucose transport capacity

scientific article published in September 2003

Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice.

scientific article published in October 2000

Structural distinction of diacyl-, alkylacyl, and alk-1-enylacyl glycerophosphocholines as [M - 15]⁻ ions by multiple-stage linear ion-trap mass spectrometry with electrospray ionization.

scientific article

TZDs and diabetes: testing the waters

scientific article published on 01 August 2005

Targeted intestinal overexpression of the immediate early gene tis7 in transgenic mice increases triglyceride absorption and adiposity

scientific article published on 5 August 2005

The ABCs of beta-cell dysfunction in type 2 diabetes

scientific article published on 01 March 2007

The effect of dietary fat intake on hepatic gene expression in LG/J AND SM/J mice.

scientific article

The gut microbiota as an environmental factor that regulates fat storage

scientific article (publication date: 2 November 2004)

The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model.

scientific article published on 6 January 2011

The low density lipoprotein receptor on human peripheral blood monocytes and lymphocytes: visualization by ligand blotting and immunoblotting techniques

scientific article published on 01 June 1986

The mitochondrial proteins NLRX1 and TUFM form a complex that regulates type I interferon and autophagy.

scientific article

The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes.

scientific article

The role of osteoprogenitors in vascular calcification.

scientific article

Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association. October 7, 2003.

scientific article published on December 2003

Transgenic mice expressing lipoprotein lipase in adipose tissue. Absence of the proximal 3'-untranslated region causes translational upregulation

scientific article published on 7 June 2003

Why we should put clothes on mice

scientific article published on 01 February 2009

p53 is required for chloroquine-induced atheroprotection but not insulin sensitization.

scientific article

List of works by Clay F. Semenkovich

"New" hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis

A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes

ASXL2 Regulates Glucose, Lipid, and Skeletal Homeostasis

Absence of peroxisome proliferator-activated receptor-alpha abolishes hypertension and attenuates atherosclerosis in the Tsukuba hypertensive mouse

Acute ether lipid deficiency affects neutrophil biology in mice

Alpha2beta1 integrin and development of atherosclerosis in a mouse model: assessment of risk

Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models.

American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome

Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis

An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension

Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2.

Autophagy links inflammasomes to atherosclerotic progression.

Bone weighs in on obesity

Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.

COOH-terminal disruption of lipoprotein lipase in mice is lethal in homozygotes, but heterozygotes have elevated triglycerides and impaired enzyme activity.

Calpain-10 is a component of the obesity-related quantitative trait locus Adip1.

De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination.

De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation.

Deletion of Tis7 Protects Mice from High-Fat Diet-Induced Weight Gain and Blunts the Intestinal Adaptive Response Postresection ⬇️

Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice

Diet-dependent genetic and genomic imprinting effects on obesity in mice.

Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

Essential amino acids regulate fatty acid synthase expression through an uncharged transfer RNA-dependent mechanism

FASN-dependent de novo lipogenesis is required for brain development

Fast predators or fast food, the fit still survive

Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?

Fatty acid synthase modulates homeostatic responses to myocardial stress.

Fatty acid synthase modulates intestinal barrier function through palmitoylation of mucin 2.

Fatty acid synthesis configures the plasma membrane for inflammation in diabetes

Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression

Fine-mapping gene-by-diet interactions on chromosome 13 in a LG/J x SM/J murine model of obesity.

Functional Deficits Precede Structural Lesions in Mice With High-Fat Diet-Induced Diabetic Retinopathy

Genetic effects at pleiotropic loci are context-dependent with consequences for the maintenance of genetic variation in populations.

Genetic evidence for discordance between obesity- and diabetes-related traits in the LGXSM recombinant inbred mouse strains.

Genetic, epigenetic, and gene-by-diet interaction effects underlie variation in serum lipids in a LG/JxSM/J murine model

Getting away from glucose: stop sugarcoating diabetes

Grb2 is required for atherosclerotic lesion formation

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Gut microbiota from twins discordant for obesity modulate metabolism in mice

Identification of a physiologically relevant endogenous ligand for PPARalpha in liver

Inactivation of fatty acid synthase impairs hepatocarcinogenesis driven by AKT in mice and humans

Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation

Increased low density lipoprotein receptor expression mediated through the insulin-like growth factor-I receptor in cultured fibroblasts

Induction of adenosine 3',5'-monophosphate-dependent protein kinase subunits during adipogenesis in vitro

Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity

Insulin Resistance and a Long, Strange Trip.

Insulin resistance and atherosclerosis

Insulin-regulated protein palmitoylation impacts endothelial cell function.

Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter ⬇️

Lysosomal dysfunction results in altered energy balance

Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice

Maternal genotype affects adult offspring lipid, obesity, and diabetes phenotypes in LGXSM recombinant inbred strains

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

Mice deficient in group VIB phospholipase A2 (iPLA2gamma) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet

Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.

Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking

Numerous transcriptional alterations in liver persist after short-term enzyme-replacement therapy in a murine model of mucopolysaccharidosis type VII.

Nutrient-dependent phosphorylation channels lipid synthesis to regulate PPARα.

Osteopontin transcription in aortic vascular smooth muscle cells is controlled by glucose-regulated upstream stimulatory factor and activator protein-1 activities

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

PPARalpha activation elevates blood pressure and does not correct glucocorticoid-induced insulin resistance in humans

PPARalpha: savior or savage?

Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion

Parent-of-origin effects propagate through networks to shape metabolic traits

Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.

Peroxisome proliferator activated receptor-δ: the middle child vies for attention

Peroxisomes: a nexus for lipid metabolism and cellular signaling.

Plasma lipids in patients with type I diabetes mellitus. Influence of race, gender, and plasma glucose control: lipids do not correlate with glucose control in black women

Quantitative trait loci affecting liver fat content in mice.

Quantitative trait loci for obesity- and diabetes-related traits and their dietary responses to high-fat feeding in LGXSM recombinant inbred mouse strains

Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans

Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease.

Respiratory uncoupling induces delta-aminolevulinate synthase expression through a nuclear respiratory factor-1-dependent mechanism in HeLa cells.

Respiratory uncoupling lowers blood pressure through a leptin-dependent mechanism in genetically obese mice

Retention of low-density lipoprotein in atherosclerotic lesions of the mouse: evidence for a role of lipoprotein lipase

Satellite glial cells promote regenerative growth in sensory neurons