List of works - Ivan Topisirovic

4E-BPs at the crossroads of oncogenic MAPK and AKT signaling.

scientific article

A Unique ISR Program Determines Cellular Responses to Chronic Stress.

scientific article published in December 2017

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development

scientific article

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway

scientific article

Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR

scientific article published in 2021

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

scientific article published on 01 July 2019

Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds.

scientific article published on May 2006

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

scientific article published on 12 August 2015

Biomedical Potential of mTOR Modulation by Nanoparticles.

scientific article

Cancer as an ecomolecular disease and a neoplastic consortium

scientific article

Cap and cap-binding proteins in the control of gene expression

scientific article published on 28 October 2010

Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands

scientific article

Carbon source and myc expression influence the antiproliferative actions of metformin

scientific article

Cell biology. Burn out or fade away?

scientific article published in March 2010

Cell biology. Trans-HSF1 express

scientific article published in July 2013

Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide

scientific article published on 18 September 2017

Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B.

scientific article published on 19 January 2010

Control of p53 multimerization by Ubc13 is JNK-regulated

scholarly article

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.

scientific article

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

scientific article published on 24 July 2020

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.

scientific article published on 24 November 2017

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex

scientific article published on 22 April 2013

Dissecting the role of mTOR: lessons from mTOR inhibitors

scientific article published on 11 December 2009

Distinct perturbation of the translatome by the antidiabetic drug metformin

scientific article

Distinct translational control in CD4+ T cell subsets

scientific article

Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of <i>Pten</i> and in the PI3K/Akt signalling cascade

scientific article published in 2022

Distinctive tRNA Repertoires in Proliferating versus Differentiating Cells

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

scientific article published on 15 February 2018

Dysregulation of mRNA translation and energy metabolism in cancer.

scientific article published on 2 November 2017

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

scientific article

Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.

scientific article

FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.

scientific article

Frequency analysis and clinical characterization of different types of spinocerebellar ataxia in Serbian patients

scientific article published in February 2006

Genetic and clinical analysis of spinocerebellar ataxia type 8 repeat expansion in Yugoslavia

scientific article published on 01 October 2002

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer

Largen: a molecular regulator of mammalian cell size control

scientific article

Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection

scientific article published on April 2011

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

scientific article published on 16 October 2017

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

scientific article

Nucleus to Mitochondria: Lost in Transcription, Found in Translation.

scientific article published in June 2016

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling

scientific article

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia

scientific article published on 01 February 2019

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

scientific article

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

scientific article published on 14 July 2020

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

scientific article published on December 2004

Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale

scientific article published on 17 May 2014

RACK1 Function in Cell Motility and Protein Synthesis.

scientific article published on September 2013

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity

scientific article published on 07 November 2019

RNA G-quadruplexes and their potential regulatory roles in translation.

scientific article published on 4 October 2016

Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

scientific article

S6K1 plays a critical role in early adipocyte differentiation

scientific article

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex

scientific article

SPANX control of Lamin A/C modulates nuclear architecture and promotes melanoma growth

scientific article published on 22 June 2020

Serine deprivation enhances antineoplastic activity of biguanides.

scientific article

Signaling pathways involved in the regulation of mRNA translation.

scientific article published on 2 April 2018

Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.

scientific article published on 29 December 2008

Targeting the translation machinery in cancer

scientific article

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.

scientific article

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

scientific article published on 30 July 2021

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

scientific article published on 14 September 2016

The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus.

scientific article

The role of eIF4E in response and acquired resistance to vemurafenib in melanoma

scientific article

Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer

scientific article

Translation Links Nutrient Availability with Inflammation

scientific article published on 14 September 2018

Translation and cancer

scientific article published on 16 May 2015

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

scientific article published in December 2018

Translational control by the eukaryotic ribosome

scientific article

Translational control of breast cancer plasticity

scientific article published on 19 May 2020

Translational control of immune responses: from transcripts to translatomes

scientific article published on June 2014

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

scientific article

Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression

scientific article published on 26 September 2019

Translational reprogramming marks adaptation to asparagine restriction in cancer

scientific article published on 18 November 2019

c-Myc steers translation in lymphoma

scientific article published on 17 June 2019

eIF4E is a central node of an RNA regulon that governs cellular proliferation

scientific article

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

scientific article (publication date: 25 April 2005)

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies

scientific article published on 24 October 2012

mRNA translation and energy metabolism in cancer: the role of the MAPK and mTORC1 pathways

scientific article

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

scientific article published on 13 September 2017

mTOR as a central regulator of lifespan and aging

scientific article published on 02 July 2019

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

scientific article

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

scientific article published on 4 April 2016

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

scientific article

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

scientific article

nanoCAGE reveals 5' UTR features that define specific modes of translation of functionally related MTOR-sensitive mRNAs

scientific article

p53-dependent translational control of senescence and transformation via 4E-BPs.

scientific article published in November 2009

List of works by Ivan Topisirovic

4E-BPs at the crossroads of oncogenic MAPK and AKT signaling.

A Unique ISR Program Determines Cellular Responses to Chronic Stress.

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development

Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway

Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

Arenavirus Z protein as an antiviral target: virus inactivation and protein oligomerization by zinc finger-reactive compounds.

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

Biomedical Potential of mTOR Modulation by Nanoparticles.

Cancer as an ecomolecular disease and a neoplastic consortium

Cap and cap-binding proteins in the control of gene expression

Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands

Carbon source and myc expression influence the antiproliferative actions of metformin

Cell biology. Burn out or fade away?

Cell biology. Trans-HSF1 express

Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide

Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B.

Control of p53 multimerization by Ubc13 is JNK-regulated

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

Cross-talk between protein synthesis, energy metabolism and autophagy in cancer.

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex

Dissecting the role of mTOR: lessons from mTOR inhibitors

Distinct perturbation of the translatome by the antidiabetic drug metformin

Distinct translational control in CD4+ T cell subsets

Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of <i>Pten</i> and in the PI3K/Akt signalling cascade

Distinctive tRNA Repertoires in Proliferating versus Differentiating Cells

Downregulation of PERK activity and eIF2α serine 51 phosphorylation by mTOR complex 1 elicits pro-oxidant and pro-death effects in tuberous sclerosis-deficient cells

Dysregulation of mRNA translation and energy metabolism in cancer.

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.

FXR1P limits long-term memory, long-lasting synaptic potentiation, and de novo GluA2 translation.

Frequency analysis and clinical characterization of different types of spinocerebellar ataxia in Serbian patients

Genetic and clinical analysis of spinocerebellar ataxia type 8 repeat expansion in Yugoslavia

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer

Largen: a molecular regulator of mammalian cell size control

Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection

MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP

Nucleus to Mitochondria: Lost in Transcription, Found in Translation.

Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling

Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

Polysome fractionation and analysis of mammalian translatomes on a genome-wide scale

RACK1 Function in Cell Motility and Protein Synthesis.

RITA requires eIF2α-dependent modulation of mRNA translation for its anti-cancer activity

RNA G-quadruplexes and their potential regulatory roles in translation.

Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap

S6K1 plays a critical role in early adipocyte differentiation

SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex

SPANX control of Lamin A/C modulates nuclear architecture and promotes melanoma growth

Serine deprivation enhances antineoplastic activity of biguanides.

Signaling pathways involved in the regulation of mRNA translation.

Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.

Targeting the translation machinery in cancer

The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner.

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

The proline-rich homeodomain (PRH/HEX) protein is down-regulated in liver during infection with lymphocytic choriomeningitis virus.

The role of eIF4E in response and acquired resistance to vemurafenib in melanoma

Translation Initiation Factors: Reprogramming Protein Synthesis in Cancer

Translation Links Nutrient Availability with Inflammation

Translation and cancer

Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

Translational control by the eukaryotic ribosome

Translational control of breast cancer plasticity

Translational control of immune responses: from transcripts to translatomes

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

Translational offsetting as a mode of estrogen receptor α-dependent regulation of gene expression

Translational reprogramming marks adaptation to asparagine restriction in cancer

c-Myc steers translation in lymphoma

eIF4E is a central node of an RNA regulon that governs cellular proliferation

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies

mRNA translation and energy metabolism in cancer: the role of the MAPK and mTORC1 pathways

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.