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List of works by Pavel Krejčí

A Chaperone Complex Formed by HSP47, FKBP65, and BiP Modulates Telopeptide Lysyl Hydroxylation of Type I Procollagen

scientific article published on 8 February 2017

A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation

scientific article published on 04 May 2017

A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells

scientific article published on 13 March 2009

A novel variant of FGFR3 causes proportionate short stature

scientific article published on 16 March 2015

ARQ 087 inhibits FGFR signaling and rescues aberrant cell proliferation and differentiation in experimental models of craniosynostoses and chondrodysplasias caused by activating mutations in FGFR1, FGFR2 and FGFR3.

scientific article published on 18 August 2017

An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.

scientific article published on 27 July 2016

Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage

scientific article

Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo.

scientific article published on 3 February 2012

Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling

scientific article published in March 2012

Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins

scientific article published on 4 December 2006

Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.

scientific article

C-natriuretic peptide: an important regulator of cartilage.

scientific article published on 6 August 2007

Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells

scientific article published on 01 June 2001

Colicin F inhibits pathogenic Yersinia enterocolitica in mice

scientific article published in Scientific Reports

Computer-Assisted Engineering of Hyperstable Fibroblast Growth Factor 2.

scientific article published on 26 December 2017

Early cycling-independent changes to p27, cyclin D2, and cyclin D3 in differentiating mouse embryonal carcinoma cells.

scientific article

Effect of FGFR inhibitors on chicken limb development.

scientific article published on 3 October 2014

Elucidation of protein interactions necessary for the maintenance of the BCR-ABL signaling complex

scientific article published on 09 December 2019

Exome sequencing identifies PDE4D mutations in acrodysostosis

scientific article published on 29 March 2012

Expression of FGF19 in human embryonic stem cells.

scientific article

FGF-2 abnormalities in B cell chronic lymphocytic and chronic myeloid leukemias.

scientific article published on February 2001

FGF-2 expression and its action in human leukemia and lymphoma cell lines

scientific article published on 01 April 2003

FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway

scientific article published on 15 October 2008

Fate of the molar dental lamina in the monophyodont mouse.

scientific article published on 26 May 2015

Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage.

scientific article

Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes

scientific article published on 12 October 2008

Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer

scientific article published on 23 January 2014

Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

scientific article published on 19 February 2019

Fibroblast growth factors 1, 2, 17, and 19 are the predominant FGF ligands expressed in human fetal growth plate cartilage

scientific article

HSP47 and FKBP65 cooperate in the synthesis of type I procollagen.

scientific article

High molecular weight FGF2: the biology of a nuclear growth factor.

scientific article published on January 2009

Inhibition of SHIP2 activity inhibits cell migration and could prevent metastasis in breast cancer cells

scientific article published on 16 August 2018

Inhibitor repurposing reveals ALK, LTK, FGFR, RET and TRK kinases as the targets of AZD1480.

scientific article published on 27 November 2017

Instability restricts signaling of multiple fibroblast growth factors.

scientific article

MORN5 Expression during Craniofacial Development and Its Interaction with the BMP and TGFβ Pathways

scientific article

Mild clinical presentation and prolonged survival of a patient with fumarase deficiency due to the combination of a known and a novel mutation in FH gene

scientific article published on 20 April 2013

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

scientific article

Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells.

scientific article published in May 2001

Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes.

scientific article published on 22 October 2015

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

scientific article published on 14 October 2020

Mutations in the EVC1 gene are not a common finding in the Ellis-van Creveld and short rib-polydactyly type III syndromes

scientific article published on 01 September 2004

NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells

scientific article

Nanodiamonds as “artificial proteins”: Regulation of a cell signalling system using low nanomolar solutions of inorganic nanocrystals

scientific article published on 21 May 2018

Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2.

scientific article published on 9 March 2010

Neutral endopeptidase-resistant C-type natriuretic peptide variant represents a new therapeutic approach for treatment of fibroblast growth factor receptor 3-related dwarfism

scientific article published on 3 February 2015

O-linked carbohydrates are required for FGF-2-mediated proliferation of mouse embryonic cells.

scientific article published on September 1999

One reporter for in-cell activity profiling of majority of protein kinase oncogenes.

scientific article published on 15 February 2017

Phenotype-genotype correlations in patients with Marinesco-Sjögren syndrome

scientific article published on 30 July 2013

Post-translational modifications regulate signalling by Ror1.

scientific article published on 27 May 2011

Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport

scientific article published on 11 September 2016

Putting the brakes on chondrosarcoma

scientific article published on 22 August 2015

Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation

scientific article

Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.

scientific article

Role of Primary Cilia in Odontogenesis.

scientific article

Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases.

scientific article

Simple, mammalian cell-based assay for identification of inhibitors of the Erk MAP kinase pathway

scientific article

Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias

scientific article

Statins do not inhibit the FGFR signaling in chondrocytes

scientific article published on 2 June 2017

The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling

scientific article published on 01 September 2018

The antiapoptotic protein Api5 and its partner, high molecular weight FGF2, are up-regulated in B cell chronic lymphoid leukemia

scientific article published on 7 September 2007

The fibroblast growth factors in multiple myeloma

scientific article published on 01 June 2006

The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases

scientific article published on 18 September 2018

The paradox of FGFR3 signaling in skeletal dysplasia: why chondrocytes growth arrest while other cells over proliferate.

scientific article published on December 2013

The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration.

scientific article

The role of p27(Kip1) in maintaining the levels of D-type cyclins in vivo

scientific article published in May 2004

Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion.

scientific article published on 20 June 2017

p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice

scientific article

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