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List of works by Frances Arnold

A Biocatalytic Platform for Synthesis of Chiral Trifluoromethylated Organoborons

A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons

A C35 carotenoid biosynthetic pathway

scientific article

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases

scientific article

A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation

scientific article published on 11 August 2016

A Versatile High Throughput Screen for Dioxygenase Activity Using Solid-Phase Digital Imaging ⬇️

scientific article published on August 1, 2001

A colorimetric assay to quantify dehydrogenase activity in crude cell lysates

scientific article

A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments

scientific article

A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure-guided recombination

scientific article

A family of thermostable fungal cellulases created by structure-guided recombination

scientific article

A general mechanism for network-dosage compensation in gene circuits

scientific article published on September 2010

A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds

scientific article

A self-sufficient peroxide-driven hydroxylation biocatalyst

scientific article published in July 2003

A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo

scientific article

A structural study of Hypocrea jecorina Cel5A

scientific article

A synthetic Escherichia coli predator-prey ecosystem

scientific article published on 15 April 2008

A synthetic multicellular system for programmed pattern formation

scientific article published in April 2005

Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions

Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions

scientific article published in 2018

An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)-H bonds

scientific article published on 14 October 2019

An integrated microfabricated cell sorter

scientific article

Analysis of shuffled gene libraries

scientific article

Anti-Markovnikov alkene oxidation by metal-oxo-mediated enzyme catalysis.

scientific article

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons

scientific article

Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases

scientific article published on 8 December 2015

Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses

scientific article published in September 2004

Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy

scientific article published on 11 March 2016

Binding and two-dimensional crystallization of streptavidin at the air/water interface via engineered Cu-IDA chelator lipids

Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways.

scientific article published on 30 January 2006

Breaking proteins with mutations: threads and thresholds in evolution

scientific article published on 30 January 2007

Catalytic iron-carbene intermediate revealed in a cytochrome carbene transferase

article published in the Proceedings of the National Academy of Sciences of the United States of America

Characterization of His-X3-His sites in α-helices of synthetic metal-binding bovine somatotropin ⬇️

scientific article published on February 1, 1991

Chemistry Takes a Bath: Reactions in Aqueous Media

scientific article published on 01 July 2018

Chemo-enzymatic fluorination of unactivated organic compounds

scientific article

Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases

scientific article published on 15 September 2009

Chemomimetic biocatalysis: exploiting the synthetic potential of cofactor-dependent enzymes to create new catalysts

scientific article published on 26 October 2015

Chimeragenesis of distantly-related proteins by noncontiguous recombination

scientific article

Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3.

scientific article published in September 2004

Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases

scientific article

Colorimetric assays for biodegradation of polycyclic aromatic hydrocarbons by fungal laccases

scientific article

Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3.

scientific article published in March 2004

Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates

scientific article published on December 2010

Combinatorial protein design by in vitro recombination ⬇️

scientific article published on June 1, 1998

Combinatorial protein design: strategies for screening protein libraries ⬇️

scientific article published on August 1, 1997

Combinatorial recombination of gene fragments to construct a library of chimeras

scientific article

Combinatorial recombination of gene fragments to construct a library of chimeras

article

Comparison of family 9 cellulases from mesophilic and thermophilic bacteria

scientific article

Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes

scientific article

Consensus protein design without phylogenetic bias

scientific article

Controlling macromolecular topology with genetically encoded SpyTag-SpyCatcher chemistry

scientific article

Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds

scientific article published on February 2014

Cytochrome P450: taming a wild type enzyme

scientific article

Design and evolution of enzymes for non-natural chemistry

scholarly article published October 2017

Designing libraries of chimeric proteins using SCHEMA recombination and RASPP.

scientific article

Direct Enzymatic Synthesis of a Deep-Blue Fluorescent Noncanonical Amino Acid from Azulene and Serine

scientific article published on 18 November 2019

Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3.

scientific article published in October 2005

Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble

scholarly article by Andrew R Buller et al published 13 June 2018 in Journal of the American Chemical Society

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore

scientific article published on 20 February 2017

Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds

scientific article published on 22 May 2019

Directed Evolution: Bringing New Chemistry to Life

scientific article published on 24 October 2017

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

scientific article published on 25 February 2009

Directed evolution of Gloeobacter violaceus rhodopsin spectral properties.

scientific article published on 28 June 2014

Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone

scientific article

Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones

scientific article

Directed evolution of a far-red fluorescent rhodopsin

scientific article

Directed evolution of a genetic circuit

scientific article

Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine

scientific article

Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents ⬇️

scientific article published on April 1, 1996

Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life.

scientific article published in November 2016

Directed evolution of enzymatic silicon-carbon bond cleavage in siloxanes

scientific article published on 25 January 2024

Directed evolution of enzyme catalysts ⬇️

scientific article published on December 1, 1997

Directed evolution of protein-based neurotransmitter sensors for MRI

scientific article

Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation

scientific article

Directed evolution: Creating biocatalysts for the future

Directed evolution: new parts and optimized function

scientific article published on 31 August 2009

Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models

scientific article published on 21 March 2016

Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes

scientific article published on 21 February 2018

Diverse engineered heme proteins enable stereodivergent cyclopropanation of unactivated alkenes

Diverse engineered heme proteins enable stereodivergent cyclopropanation of unactivated alkenes

Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s

scientific article

Diversifying carotenoid biosynthetic pathways by directed evolution

scientific article

Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR.

scientific article

Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device

scientific article

Efficient sampling of SCHEMA chimera families to identify useful sequence elements

scientific article published in January 2013

Efficient screening of fungal cellobiohydrolase class I enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination

scientific article published on 16 September 2010

Enantiodivergent α-Amino C-H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s

scientific article published on 12 June 2019

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein

scientific article published on 25 January 2019

Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450

scientific article

Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme.

scientific article published on 19 July 2017

Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.

scientific article published on May 2006

Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.

scientific article published in January 2006

Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transfer

scientific article

Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo

scientific article published on 24 July 2013

Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme

scientific article

Engineered Biosynthesis of β-Alkyl Tryptophan Analogs

Engineered Biosynthesis of β-Alkyl Tryptophan Analogues

Engineered Biosynthesis of β-Alkyl Tryptophan Analogues

scientific article published on 12 October 2018

Engineered Cytochrome -Catalyzed Lactone-Carbene B-H Insertion

scientific article published on 14 January 2019

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

scientific article

Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium

scientific article

Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli

scientific article published on May 2011

Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures

scientific article

Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose hydrolysis at elevated temperatures

scientific article published on 5 August 2014

Engineering Chemoselectivity in Hemoprotein-Catalyzed Indole Amidation

scientific article published on 07 August 2019

Engineering by homologous recombination: exploring sequence and function within a conserved fold

scientific article

Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes

scientific article published on 29 March 2020

Engineering enzymes for non-aqueous solvents

scientific article published on September 1, 1990

Engineering enzymes for noncanonical amino acid synthesis

Engineering microbial consortia: a new frontier in synthetic biology

scientific article published on 31 July 2008

Engineering proteins that bind, move, make and break DNA

scientific article published in December 2003

Engineering proteins that bind, move, make and break DNA.

scientific article

Enhancement of cellulosome-mediated deconstruction of cellulose by improving enzyme thermostability

scientific article

Enzymatic Primary Amination of Benzylic and Allylic C(sp3)-H Bonds

scientific article published on 25 May 2020

Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp3 C-H functionalization.

scientific article

Enzymatic construction of highly strained carbocycles

scientific article published in Science

Enzymatic functionalization of carbon-hydrogen bonds

scientific article

Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated Structural Analysis and Library Design

scientific article published in January 2018

Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media

scientific article published on March 1, 1991

Enzyme engineering for nonaqueous solvents: random mutagenesis to enhance activity of subtilisin E in polar organic media

scientific article published on November 1, 1991

Enzyme engineering reaches the boiling point ⬇️

scientific article published on March 3, 1998

Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination

scientific article

Erratum: Corrigendum: Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR

scientific article published in August 2006

Evolution favors protein mutational robustness in sufficiently large populations

scientific article

Evolution of a pathway to novel long-chain carotenoids

scientific article

Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway

scientific article

Evolutionary history of a specialized p450 propane monooxygenase

scientific article (publication date: 28 November 2008)

Evolving strategies for enzyme engineering

scientific article

Expanding P450 catalytic reaction space through evolution and engineering

scientific article

Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution

scientific article published on 3 February 2015

Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions

scientific article

Exploring protein fitness landscapes by directed evolution

scientific article

Exploring the Diversity of Heme Enzymes through Directed Evolution

Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination

scientific article

Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution ⬇️

scientific article published on September 1, 2001

Fancy footwork in the sequence space shuffle

scientific article published in March 2006

Functional Expression of a Fungal Laccase in by Directed Evolution

scientific article published in 2003

Functional and nonfunctional mutations distinguished by random recombination of homologous genes ⬇️

scientific article published on July 22, 1997

Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach

scientific article published in March 2004

Functional expression of a fungal laccase in Saccharomyces cerevisiae by directed evolution.

scientific article

General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH

scientific article

General method for sequence-independent site-directed chimeragenesis

scientific article

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo

scientific article published on 23 July 2015

Genetically programmed chiral organoborane synthesis.

scientific article published on 29 November 2017

Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity

scientific article

High Throughput Screening with SAMDI Mass Spectrometry for Directed Evolution

scientific article published on 11 November 2020

High throughput screening of fungal endoglucanase activity in Escherichia coli

scientific article

High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase

High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase

scientific article published on 26 March 2013

Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor

scientific article published on 17 October 2016

Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods.

scientific article published on 7 September 2012

How interprofessional learning improves care

scientific article published in May 2013

Hypocrea jecorina cellobiohydrolase I stabilizing mutations identified using noncontiguous recombination

scientific article

Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes

scientific article published on 30 August 2016

Implications of rewiring bacterial quorum sensing

scientific article

Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran

Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima

scientific article published on 27 April 2018

Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran

scientific article

Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli

scientific article published on 10 November 2010

In the light of directed evolution: pathways of adaptive protein evolution

scientific article

In vivo evolution of butane oxidation by terminal alkane hydroxylases AlkB and CYP153A6.

scientific article published on 14 November 2008

Innenrücktitelbild: High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase (Angew. Chem. 21/2013)

Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture)

scientific article published on 21 August 2019

Innovation by homologous recombination

scientific article

Inside Back Cover: High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase (Angew. Chem. Int. Ed. 21/2013)

Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius

scientific article published on 8 April 2014

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

scientific article published on 7 October 2002

Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents

scientific article published in February 2004

Learned protein embeddings for machine learning

scientific article published on 01 December 2018

Learned protein embeddings for machine learning

scientific article published on 01 August 2018

Library analysis of SCHEMA-guided protein recombination

scientific article

Long-term monitoring of bacteria undergoing programmed population control in a microchemostat

scientific article published in July 2005

Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization.

scientific article published on 23 October 2017

Machine learning-assisted directed protein evolution with combinatorial libraries

scientific article published on 12 April 2019

Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics

scientific article published on 14 October 2019

Machine-learning-guided directed evolution for protein engineering

scientific article published on 15 July 2019

Metal-affinity separations: a new dimension in protein processing

scientific article published on February 1, 1991

Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity ⬇️

scientific article published on February 2011

Method to protect a targeted amino acid residue during random mutagenesis

scientific article

Modification of galactose oxidase to introduce glucose 6-oxidase activity

scientific article published in August 2002

Molecular evolution by staggered extension process (StEP) in vitro recombination ⬇️

scientific article published on March 1, 1998

Molecularly imprinted polymers on silica: selective supports for high-performance ligand-exchange chromatography ⬇️

scientific article published on July 28, 1995

Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes

scientific article published on 27 October 2015

Navigating the protein fitness landscape with Gaussian processes

scientific article published on 31 December 2012

Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution

scientific article

Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Cofactors

Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Ligands

scientific article published on 06 December 2019

Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins

scientific article

Noncontiguous SCHEMA protein recombination

scientific article

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes ⬇️

scientific article (publication date: 20 December 2012)

On the conservative nature of intragenic recombination

scientific article

Optimizing non-natural protein function with directed evolution

scientific article

P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions

scientific article

Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

scientific article

Programmed population control by cell-cell communication and regulated killing

scientific article published on 4 April 2004

Protein building blocks preserved by recombination

scientific article

Protein dynamics in a family of laboratory evolved thermophilic enzymes

scientific article published in March 2003

Protein engineering of oxygenases for biocatalysis

scientific article

Protein stability promotes evolvability

scientific article

Protein stabilization by engineered metal chelation

scientific article published on October 1, 1991

Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3.

scientific article

Random field model reveals structure of the protein recombinational landscape

scientific article

Random-priming in vitro recombination: An effective tool for directed evolution ⬇️

scientific article published on January 15, 1998

Recent advances in engineering microbial rhodopsins for optogenetics

scientific article

Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes

scientific article

Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.

scientific article published in November 2003

Retraction

scientific article retraction published on 03 January 2020

Reversal of NAD(P)H cofactor dependence by protein engineering

scientific article

Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases

scientific article published on 12 May 2013

SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability

scientific article

SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis

scientific article

SCHEMA-guided protein recombination

scientific article published in January 2004

Scalable continuous evolution for the generation of diverse enzyme variants encompassing promiscuous activities

scientific article published on 06 November 2020

Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity

scientific article published on 18 October 2018

Selective Enzymatic Oxidation of Silanes to Silanols

scientific article published on 24 March 2020

Selective Enzymatic Oxidation of Silanes to Silanols

Self-organization, layered structure, and aggregation enhance persistence of a synthetic biofilm consortium

scientific article

Signal Peptides Generated by Attention-Based Neural Networks

scientific article published on 10 July 2020

Site-directed protein recombination as a shortest-path problem

scientific article

Site-selective enzymatic C‒H amidation for synthesis of diverse lactams

scientific article

Site-selective enzymatic C‒H amidation for synthesis of diverse lactams

scientific article published on 3 January 2020

Stability and the evolvability of function in a model protein

scientific article

Staggered extension process (StEP) in vitro recombination.

scientific article published in January 2002

Staggered extension process (StEP) in vitro recombination.

scientific article

Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes

Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3.

scientific article published on 6 April 2005

Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences 1 1Edited by J. Wells ⬇️

scientific article published on September 26, 1997

Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450.

scientific article

Structural determinants of the rate of protein evolution in yeast.

scientific article

Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE.

scientific article

Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin

scientific article

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins

scientific article

Structure-guided SCHEMA recombination of distantly related beta-lactamases

scientific article published on 6 November 2006

Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol

scientific article

Structure-guided recombination creates an artificial family of cytochromes P450.

scientific article

Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry

scientific article

Synthesis of β-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase

scientific article published on 29 June 2016

Synthetic biology: Engineering explored

scientific article published in May 2014

Synthetic gene circuits: design with directed evolution

scientific article published on January 2007

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation

scientific article published on 06 December 2019

Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation

The nature of chemical innovation: new enzymes by evolution

scientific article

The temkin isotherm describes heterogeneous protein adsorption ⬇️

scientific article published on March 15, 1995

Thermodynamic prediction of protein neutrality

scientific article

Thermostabilization of a cytochrome p450 peroxygenase.

scientific article published in September 2003

Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity

scientific article published on 9 December 2016

Tryptophan Synthase: Biocatalyst Extraordinaire

scientific article published on 16 July 2020

Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues

scientific article published on 14 July 2017

Validation of the Baveno VI criteria to identify low risk cirrhotic patients not requiring endoscopic surveillance for varices.

scientific article

When blind is better: Protein design by evolution ⬇️

scientific article published on July 1, 1998

Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins

scientific article published in July 2005

Why highly expressed proteins evolve slowly

scientific article

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