List of works - Oleg Fedorov

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

scientific article

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes

scientific article

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

scientific article

Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.

scientific article

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

scientific article

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

scientific article published on 30 January 2013

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

scientific article published in 2011

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

scientific article

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

scientific article

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

scientific article

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

scientific article published on 24 November 2020

Insights for the development of specific kinase inhibitors by targeted structural genomics

scientific article published on 29 March 2007

Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

scientific article

Kinase inhibitor selectivity profiling using differential scanning fluorimetry

scientific article

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

scientific article published on 26 May 2011

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

scientific article

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

scientific article

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

scientific article published on 12 October 2016

Propionate analogues of zearalenone bind to Hsp90.

scientific article

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

scientific article

Resonance assignment of the RGS domain of human RGS10

scientific article published on 19 December 2006

RhoB can adopt a Mg2+free conformation prior to GEF binding

scientific article published on 01 July 2008

Selective inhibition of BET bromodomains

scientific article

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

scientific article published on 13 November 2015

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

scientific article

Structural Comparison of Human Mammalian Ste20-Like Kinases

scientific article published on 6 August 2010

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

scientific article

Structural and Functional Characterization of the Human Protein Kinase ASK1

scientific article

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

scientific article

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

scientific article

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1

scientific article

Structure and regulation of the human Nek2 centrosomal kinase

scientific article

Structure of dystrophia myotonica protein kinase

scientific article

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

scientific article

The (un)targeted cancer kinome

scientific article published in March 2010

The Cryptosporidium parvum Kinome ⬇️

scientific article

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

scientific article published on January 2013

Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD

scientific article published on 05 September 2013

List of works by Oleg Fedorov

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

7,8-Dichloro-1-oxo-β-carbolines as a Versatile Scaffold for the Development of Potent and Selective Kinase Inhibitors with Unusual Binding Modes

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1.

Benzodiazepines and benzotriazepines as protein interaction inhibitors targeting bromodomains of the BET family

Bromo-deaza-SAH: a potent and selective DOT1L inhibitor

Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery

Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking

Insights for the development of specific kinase inhibitors by targeted structural genomics

Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation

Kinase inhibitor selectivity profiling using differential scanning fluorimetry

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

Propionate analogues of zearalenone bind to Hsp90.

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

Resonance assignment of the RGS domain of human RGS10

RhoB can adopt a Mg2+free conformation prior to GEF binding

Selective inhibition of BET bromodomains

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

Structural Comparison of Human Mammalian Ste20-Like Kinases

Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity

Structural and Functional Characterization of the Human Protein Kinase ASK1

Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits

Structural plasticity of histones H3-H4 facilitates their allosteric exchange between RbAp48 and ASF1

Structure and regulation of the human Nek2 centrosomal kinase

Structure of dystrophia myotonica protein kinase

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

The (un)targeted cancer kinome

The Cryptosporidium parvum Kinome ⬇️

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD