List of works - John K. Walker

1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

scientific article published on 3 April 2010

1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

scientific article published on 01 May 2010

Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.

scientific article published on 6 May 2010

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

scientific journal article

Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase

scientific article published on 13 May 2011

Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).

scientific article published on March 2010

Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate

scientific article published on 15 December 2011

Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase.

scientific article published on 31 March 2010

Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase

scientific article

Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase

scientific article published on 11 May 2011

Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.

scientific article published on 26 June 2017

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

scientific article

Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase

scientific article published on 14 February 2010

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

scientific article

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system

scientific article

Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region

scientific article

Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa

scientific article published on 25 May 2018

Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.

scientific article published on 10 July 2009

Small Molecule Condensin Inhibitors

article

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804

scientific article

The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein

scientific article published on 16 May 2017

Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism

scientific article

List of works by John K. Walker

1-(2-(2,2,2-trifluoroethoxy)ethyl-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

1-(2-Ethoxyethyl)-1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors

Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase

Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).

Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate

Discovery of 5-substituted-N-arylpyridazinones as inhibitors of p38 MAP kinase.

Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase

Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase

Identification and Structure-Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli.

Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics.

Identification of SD-0006, a potent diaryl pyrazole inhibitor of p38 MAP kinase

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system

Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region

Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa

Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.

Small Molecule Condensin Inhibitors

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804

The structural basis for inhibition of the classical and lectin complement pathways by S. aureus extracellular adherence protein

Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism