List of works - Paul W. Fedak

Acellular bioscaffolds redirect cardiac fibroblasts and promote functional tissue repair in rodents and humans with myocardial injury

scientific article published on 11 June 2020

Adhesive-Enhanced Sternal Closure: Feasibility and Safety of Late Sternal Reentry

scientific article published on 29 May 2017

Adhesive-enhanced sternal closure to improve postoperative functional recovery: a pilot, randomized controlled trial

scientific article published on 01 October 2011

Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy.

scientific article published on 9 January 2006

Aortic Valve Replacement in an Era of Rapid Innovation: Better the Devil You Know.

scientific article published in April 2018

Aortic Valve Stenosis Alters Expression of Regional Aortic Wall Shear Stress: New Insights From a 4-Dimensional Flow Magnetic Resonance Imaging Study of 571 Subjects.

scientific article published on 13 September 2017

Aortic diameter: The beginning of the end of an era

scientific article published on 13 February 2018

Aortic valve malformations and pulmonary autograft root dilatation

scientific article published on 01 June 2002

Applications of a Specialty Bicuspid Aortic Valve Program: Clinical Continuity and Translational Collaboration

scientific article published on 05 May 2020

Assessing wall stresses in bicuspid aortic valve-associated aortopathy: Forecasting the perfect storm?

scientific article published on 31 March 2018

Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy

scientific article

Bicuspid aortic valve and the specialty clinic: are your patients at risk?

scientific article published on 06 March 2017

Bicuspid aortic valve aortopathy: mechanistic and clinical insights from recent studies

scientific article published on March 2017

Bicuspid aortic valve syndrome: heterogeneous but predictable?

scientific article published on 03 January 2008

Bicuspid aortic valve-associated aortopathy: update on biomarkers.

scientific article published on 31 October 2017

Bicuspid aortopathy and the development of individualized resection strategies

scientific article published on 28 September 2014

Bridging to heart transplant with extracorporeal membrane oxygenation: Good or VAD?

scientific article published on 9 December 2017

C-Reactive protein upregulates receptor for advanced glycation end products expression in human endothelial cells.

scientific article published on 17 July 2006

C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis

scientific article published in December 2003

C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells.

scientific article

C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease.

scientific article published on 12 April 2004

C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle

scientific article published on 17 March 2003

C-reactive protein upregulates complement-inhibitory factors in endothelial cells

scientific article published on 16 February 2004

Can statin therapy alter the natural history of bicuspid aortic valves?

scientific article published on 01 June 2005

Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology/Canadian Society of Cardiac Surgery position statement on revascularization--multivessel coronary artery disease

scientific article

Canadian cardiac surgeons' perspectives on biomedical innovation.

scientific article published on 15 August 2012

Cardiac progenitor cell sheet regenerates myocardium and renews hope for translation

scientific article

Cardiac regeneration with embryonic stem cells: historic recapitulation of heart transplantation

scientific article published in December 2008

Cardiac remodeling and failure From molecules to man (Part II).

scientific article

Cardiac restoration by cell transplantation.

scientific article published in June 2004

Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines

scientific article

Caveolin: a key target for modulating nitric oxide availability in health and disease.

scientific article

Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism.

scientific article published on 16 April 2012

Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor.

scientific article published on 13 October 2005

Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism.

scientific article published on 13 October 2005

Cell transplantation to improve ventricular function in the failing heart.

scientific article

Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice

scientific article

Characterization of abnormal wall shear stress using 4D flow MRI in human bicuspid aortopathy

scientific article

Clinical and pathophysiological implications of a bicuspid aortic valve.

scientific article

Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation

scientific article

Comparison of outcomes and presentation in men-versus-women with bicuspid aortic valves undergoing aortic valve replacement.

scientific article published on 18 April 2015

Determinants of health-related quality of life in adults with congenital heart disease.

scientific article published in September 2007

Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure

scientific article published on 23 February 2016

Does ischemic preconditioning afford clinically relevant cardioprotection?

scientific article published on January 2003

Effect of aortic aneurysm replacement on outcomes after bicuspid aortic valve surgery: validation of contemporary guidelines.

scientific article published on 20 March 2014

Endothelial progenitor cells: new hope for a broken heart

scientific article

Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein

scientific article

Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins

scientific article

Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation

scientific article published on 26 August 2004

Enhancing sternal closure using Kryptonite bone adhesive: technical report

scientific article published on 07 July 2011

Epicardial infarct repair with basic fibroblast growth factor-enhanced CorMatrix-ECM biomaterial attenuates postischemic cardiac remodeling

scientific article published on 26 September 2013

Epicardial infarct repair with bioinductive extracellular matrix promotes vasculogenesis and myocardial recovery.

scientific article

Evaluation of a novel sutureless anastomotic connector: from endothelial function to mid-term clinical and angiographic follow-up.

scientific article published in November 2003

Evolution of Precision Medicine and Surgical Strategies for Bicuspid Aortic Valve-Associated Aortopathy

scientific article

Evolving concepts and technologies in mitral valve repair.

scientific article published on February 2008

Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling

scientific article published on 7 May 2015

Fundamentals of reperfusion injury for the clinical cardiologist.

scientific article

Glitazones and heart failure: critical appraisal for the clinician.

scientific article

Health technology assessments and innovation

scientific article

Heparin Augmentation Enhances Bioactive Properties of Acellular Extracellular Matrix Scaffold

scientific article published on 29 April 2017

Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.

scientific article

Human cardiac fibroblast extracellular matrix remodeling: dual effects of tissue inhibitor of metalloproteinase-2.

scientific article published on 21 June 2014

Human pericardial proteoglycan 4 (lubricin): Implications for postcardiotomy intrathoracic adhesion formation

scientific article published on 26 April 2018

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress

scientific article published on 13 June 2018

Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism

scientific article

Hyperglycemia potentiates the proatherogenic effects of C-reactive protein: reversal with rosiglitazone.

scientific article published on April 2003

Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: reversal by means of endothelin antagonism.

scientific article

Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice

scientific article published on 06 November 2006

Invited commentary

scientific article published on 01 August 2003

Is Concomitant Aortopathy Unique With Bicuspid Aortic Valve Stenosis?

scientific article published on 01 April 2016

Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons.

scientific article published on 26 August 2013

Kryptonite bone cement prevents pathologic sternal displacement

scientific article

Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.

scientific article published on 19 May 2014

Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1.

scientific article

Na(+) current expression in human atrial myofibroblasts: identity and functional roles.

scientific article published on 7 August 2014

Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells

scientific article

Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation

scientific article

Perioperative evaluation of regional aortic wall shear stress patterns in patients undergoing aortic valve and/or proximal thoracic aortic replacement.

scientific article published on 16 November 2017

Real estate of the bicuspid aorta: Location, location, location!

scientific article published on 27 February 2016

Reply: Final Common Pathway of Aortic Dilation?: Heterogeneity of Aortic Wall Property Causes the Aneurysmal Change

scientific article published on February 2016

Reply: Importance of Stress Mapping of Aortic Wall in Aortic Valve Disease.

scientific article published on April 2016

Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction

scientific article

Response to letter regarding article, "Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy"

scientific article published on November 2014

Role of mutation and pharmacologic block of human KCNH2 in vasculogenesis and fetal mortality: partial rescue by transforming growth factor-β.

scientific article published on 3 February 2015

Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy

scientific article published in March 2004

Safety and efficacy of prophylactic negative pressure wound therapy following open saphenous vein harvest in cardiac surgery: a feasibility study

scientific article

Seeing a tree through the forest: Precision medicine tools can enhance donor allocation in heart transplantation.

scientific article published on 9 December 2017

Statin Use and Aneurysm Risk in Patients With Bicuspid Aortic Valve Disease.

scientific article published on 22 December 2015

Stem cell factor deficiency is vasculoprotective: unraveling a new therapeutic potential of imatinib mesylate

scientific article published on 24 August 2006

TIMP-3 deficiency accelerates cardiac remodeling after myocardial infarction.

scientific article

TIMP-3 deficiency leads to dilated cardiomyopathy.

scientific article published on 19 July 2004

Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury

scientific article

Tetrandrine reverses human cardiac myofibroblast activation and myocardial fibrosis.

scientific article

The Cost of Frailty in Cardiac Surgery

scientific article published on 25 May 2017

The molecular fingerprint of bicuspid aortopathy

scientific article published in May 2013

The role of the plasma from platelet concentrates in transfusion reactions

scientific article

Transplantation of cryopreserved muscle cells in dilated cardiomyopathy: effects on left ventricular geometry and function

scientific article

Using Acellular Bioactive Extracellular Matrix Scaffolds to Enhance Endogenous Cardiac Repair.

scientific article

Valve-Related Hemodynamics Mediate Human Bicuspid Aortopathy: Insights From Wall Shear Stress Mapping.

scientific article

Variation in the histopathological features of patients with ascending aortic aneurysms: a study of 111 surgically excised cases.

scientific article published on 15 October 2007

Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation.

scientific article

Year in review: bicuspid aortopathy

scientific article published on 23 January 2016

List of works by Paul W. Fedak

Acellular bioscaffolds redirect cardiac fibroblasts and promote functional tissue repair in rodents and humans with myocardial injury

Adhesive-Enhanced Sternal Closure: Feasibility and Safety of Late Sternal Reentry

Adhesive-enhanced sternal closure to improve postoperative functional recovery: a pilot, randomized controlled trial

Altered expression of disintegrin metalloproteinases and their inhibitor in human dilated cardiomyopathy.

Aortic Valve Replacement in an Era of Rapid Innovation: Better the Devil You Know.

Aortic Valve Stenosis Alters Expression of Regional Aortic Wall Shear Stress: New Insights From a 4-Dimensional Flow Magnetic Resonance Imaging Study of 571 Subjects.

Aortic diameter: The beginning of the end of an era

Aortic valve malformations and pulmonary autograft root dilatation

Applications of a Specialty Bicuspid Aortic Valve Program: Clinical Continuity and Translational Collaboration

Assessing wall stresses in bicuspid aortic valve-associated aortopathy: Forecasting the perfect storm?

Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy

Bicuspid aortic valve and the specialty clinic: are your patients at risk?

Bicuspid aortic valve aortopathy: mechanistic and clinical insights from recent studies

Bicuspid aortic valve syndrome: heterogeneous but predictable?

Bicuspid aortic valve-associated aortopathy: update on biomarkers.

Bicuspid aortopathy and the development of individualized resection strategies

Bridging to heart transplant with extracorporeal membrane oxygenation: Good or VAD?

C-Reactive protein upregulates receptor for advanced glycation end products expression in human endothelial cells.

C-reactive protein activates the nuclear factor-kappaB signal transduction pathway in saphenous vein endothelial cells: implications for atherosclerosis and restenosis

C-reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells.

C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease.

C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle

C-reactive protein upregulates complement-inhibitory factors in endothelial cells

Can statin therapy alter the natural history of bicuspid aortic valves?

Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology/Canadian Society of Cardiac Surgery position statement on revascularization--multivessel coronary artery disease

Canadian cardiac surgeons' perspectives on biomedical innovation.

Cardiac progenitor cell sheet regenerates myocardium and renews hope for translation

Cardiac regeneration with embryonic stem cells: historic recapitulation of heart transplantation

Cardiac remodeling and failure From molecules to man (Part II).

Cardiac restoration by cell transplantation.

Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines

Caveolin: a key target for modulating nitric oxide availability in health and disease.

Cell therapy limits myofibroblast differentiation and structural cardiac remodeling: basic fibroblast growth factor-mediated paracrine mechanism.

Cell transplantation preserves cardiac function after infarction by infarct stabilization: augmentation by stem cell factor.

Cell transplantation preserves matrix homeostasis: a novel paracrine mechanism.

Cell transplantation to improve ventricular function in the failing heart.

Cell-based gene therapy modifies matrix remodeling after a myocardial infarction in tissue inhibitor of matrix metalloproteinase-3-deficient mice

Characterization of abnormal wall shear stress using 4D flow MRI in human bicuspid aortopathy

Clinical and pathophysiological implications of a bicuspid aortic valve.

Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation

Comparison of outcomes and presentation in men-versus-women with bicuspid aortic valves undergoing aortic valve replacement.

Determinants of health-related quality of life in adults with congenital heart disease.

Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure

Does ischemic preconditioning afford clinically relevant cardioprotection?

Effect of aortic aneurysm replacement on outcomes after bicuspid aortic valve surgery: validation of contemporary guidelines.

Endothelial progenitor cells: new hope for a broken heart

Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein

Endothelin blockade potentiates endothelial protective effects of ACE inhibitors in saphenous veins

Enhanced IGF-1 expression improves smooth muscle cell engraftment after cell transplantation

Enhancing sternal closure using Kryptonite bone adhesive: technical report

Epicardial infarct repair with basic fibroblast growth factor-enhanced CorMatrix-ECM biomaterial attenuates postischemic cardiac remodeling

Epicardial infarct repair with bioinductive extracellular matrix promotes vasculogenesis and myocardial recovery.

Evaluation of a novel sutureless anastomotic connector: from endothelial function to mid-term clinical and angiographic follow-up.

Evolution of Precision Medicine and Surgical Strategies for Bicuspid Aortic Valve-Associated Aortopathy

Evolving concepts and technologies in mitral valve repair.

Fibroblast growth factor-2 regulates human cardiac myofibroblast-mediated extracellular matrix remodeling

Fundamentals of reperfusion injury for the clinical cardiologist.

Glitazones and heart failure: critical appraisal for the clinician.

Health technology assessments and innovation

Heparin Augmentation Enhances Bioactive Properties of Acellular Extracellular Matrix Scaffold

Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction.

Human cardiac fibroblast extracellular matrix remodeling: dual effects of tissue inhibitor of metalloproteinase-2.

Human pericardial proteoglycan 4 (lubricin): Implications for postcardiotomy intrathoracic adhesion formation

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress

Hyperglycemia exaggerates ischemia-reperfusion-induced cardiomyocyte injury: reversal with endothelin antagonism

Hyperglycemia potentiates the proatherogenic effects of C-reactive protein: reversal with rosiglitazone.

Increased endothelin-1 production in diabetic patients after cardioplegic arrest and reperfusion impairs coronary vascular reactivity: reversal by means of endothelin antagonism.

Integrin-linked kinase expression is elevated in human cardiac hypertrophy and induces hypertrophy in transgenic mice

Invited commentary

Is Concomitant Aortopathy Unique With Bicuspid Aortic Valve Stenosis?

Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons.

Kryptonite bone cement prevents pathologic sternal displacement

Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.

Monocytes increase human cardiac myofibroblast-mediated extracellular matrix remodeling through TGF-β1.

Na(+) current expression in human atrial myofibroblasts: identity and functional roles.

Novel cardioprotective effects of pravastatin in human ventricular cardiomyocytes subjected to hypoxia and reoxygenation: beneficial effects of statins independent of endothelial cells

Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation

Perioperative evaluation of regional aortic wall shear stress patterns in patients undergoing aortic valve and/or proximal thoracic aortic replacement.

Real estate of the bicuspid aorta: Location, location, location!