List of works - Giorgio Seano

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

scientific article

A cerebellar window for intravital imaging of normal and disease states in mice

scientific article published on 5 October 2017

ANGI-04Olig2 REGULATES Wnt7b EXPRESSION AND VASCULATURE CHARACTERISTICS IN GLIOMA.

scientific article

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

scientific article published on 4 April 2016

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

scientific article

Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy

scientific article

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.

scientific article published on 4 April 2016

Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.

scientific article

Human Arterial Ring Angiogenesis Assay

scientific article

IMST-40. REPROGRAMMING OF THE TUMOR IMMUNE MICROENVIRONMENT BY AN ANG-2/VEGF BISPECIFIC ANTIBODY DELAYS TUMOR GROWTH AND PROLONGS SURVIVAL IN PRECLINICAL GBM MODELS

In vivo compression and imaging in mouse brain to measure the effects of solid stress

scientific article published on 17 July 2020

Increased expression of alpha6 integrin in endothelial cells unveils a proangiogenic role for basement membrane

scientific article published on 22 June 2010

Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.

scientific article

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.

scientific article published on 22 March 2018

Modeling human tumor angiogenesis in a three-dimensional culture system.

scientific article published on 7 March 2013

Neuroligin 1 induces blood vessel maturation by cooperating with the α6 integrin

scientific article published on 23 May 2014

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

scientific article published on 01 February 2019

PDK1 regulates focal adhesion disassembly by modulating endocytosis of αvβ3 integrin

scientific article published on 14 January 2015

PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.

scientific article

Podosomes and invadopodia: tools to breach vascular basement membrane

scientific article

Podosomes as novel players in endothelial biology

scientific article published on 07 August 2014

Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment

scientific article published on 7 November 2015

Quantifying solid stress and elastic energy from excised or in situ tumors.

scientific article published on 19 April 2018

Real-time monitoring of cell protrusion dynamics by impedance responses.

scientific article

Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.

scientific article

Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models

scientific article published on 05 October 2009

Solid stress and elastic energy as measures of tumour mechanopathology

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

scientific article published on 07 January 2019

Targeting the perivascular niche in brain tumors

scientific article published on 14 November 2017

The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

scientific article

Three-dimensional chemotaxis-driven aggregation of tumor cells

scientific article

Unraveling the influence of endothelial cell density on VEGF-A signaling

scientific article published on 17 April 2012

Vascular beds maintain pancreatic tumour explants for ex vivo drug screening.

scientific article published in June 2017

Vessel co-option in glioblastoma: emerging insights and opportunities

scientific article published on 02 November 2019

List of works by Giorgio Seano

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.

A cerebellar window for intravital imaging of normal and disease states in mice

ANGI-04Olig2 REGULATES Wnt7b EXPRESSION AND VASCULATURE CHARACTERISTICS IN GLIOMA.

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature and improves small molecule delivery

Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy

Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.

Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis.

Human Arterial Ring Angiogenesis Assay

IMST-40. REPROGRAMMING OF THE TUMOR IMMUNE MICROENVIRONMENT BY AN ANG-2/VEGF BISPECIFIC ANTIBODY DELAYS TUMOR GROWTH AND PROLONGS SURVIVAL IN PRECLINICAL GBM MODELS

In vivo compression and imaging in mouse brain to measure the effects of solid stress

Increased expression of alpha6 integrin in endothelial cells unveils a proangiogenic role for basement membrane

Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.

Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice.

Modeling human tumor angiogenesis in a three-dimensional culture system.

Neuroligin 1 induces blood vessel maturation by cooperating with the α6 integrin

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

PDK1 regulates focal adhesion disassembly by modulating endocytosis of αvβ3 integrin

PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction.

Podosomes and invadopodia: tools to breach vascular basement membrane

Podosomes as novel players in endothelial biology

Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment

Quantifying solid stress and elastic energy from excised or in situ tumors.

Real-time monitoring of cell protrusion dynamics by impedance responses.

Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients.

Semaphorin 3A is an endogenous angiogenesis inhibitor that blocks tumor growth and normalizes tumor vasculature in transgenic mouse models

Solid stress and elastic energy as measures of tumour mechanopathology

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

Targeting the perivascular niche in brain tumors

The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β.

Three-dimensional chemotaxis-driven aggregation of tumor cells

Unraveling the influence of endothelial cell density on VEGF-A signaling

Vascular beds maintain pancreatic tumour explants for ex vivo drug screening.

Vessel co-option in glioblastoma: emerging insights and opportunities