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List of works by Stephan J Reshkin

"The new pH-centric anticancer paradigm in Oncology and Medicine"; SCB, 2017.

scientific article published on 27 February 2017

A novel NHE1-centered signaling cassette drives epidermal growth factor receptor-dependent pancreatic tumor metastasis and is a target for combination therapy.

scientific article

Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells.

scientific article

Antibiotic therapy affects functional behaviour in cystic fibrosis blood mononuclear cells.

scientific article published on 11 June 2015

Apical and basolateral effects of PTH in OK cells: transport inhibition, messenger production, effects of pertussis toxin, and interaction with a PTH analog

scientific article published in December 1991

Assessment of different 3D culture systems to study tumor phenotype and chemosensitivity in pancreatic ductal adenocarcinoma

scientific article published on 10 May 2016

Association of pS2 (TFF1) release with breast tumour proliferative rate: in vitro and in vivo studies.

scientific article published on April 1999

Basolateral amino acid and glucose transport by the intestine of the teleost, Anguilla anguilla

scientific article published on 01 January 1988

Basolateral glucose transport by intestine of teleost, Oreochromis mossambicus.

scientific article published in March 1987

Basolateral inositol transport by intestines of carnivorous and herbivorous teleosts

scientific article published on 01 March 1989

Beta-oestradiol rescues DeltaF508CFTR functional expression in human cystic fibrosis airway CFBE41o- cells through the up-regulation of NHERF1.

scientific article published on July 2008

Biological role of NHERF1 protein expression in breast cancer.

scientific article

Brush-border inositol transport by intestines of carnivorous and herbivorous teleosts

scientific article published on 01 March 1989

CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity

scientific article published on 2 February 2012

Calcium-sensing receptor-mediated osteogenic and early-stage neurogenic differentiation in umbilical cord matrix mesenchymal stem cells from a large animal model

scientific article

Cancer Associated Fibroblast (CAF) Regulation of PDAC Parenchymal (CPC) and CSC Phenotypes Is Modulated by ECM Composition

scientific article published in 2022

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research

scientific article

Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases.

scientific article published on 10 February 2017

Characterization of a h-3 GnRH method for the measurement of GnRH binding-sites in human breast-cancer and breast-cancer cell-lines

scientific article published on 01 August 1995

Characterization of mitochondrial function in cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.

scientific article published on 5 May 2016

Corrigendum: Extracellular matrix composition modulates PDAC parenchymal and stem cell plasticity and behavior through the secretome

scientific article published on 28 August 2019

Cytokeratins and proliferation in breast cancer patients

scientific article

Dietary hormonal modification of growth, intestinal ATPase, and glucose transport in tilapia

scientific article published on 01 May 1989

Differential responsiveness of proliferation and cytokeratin release to stripped serum and oestrogen in the human breast cancer cell line, MCF-7.

scientific article published on May 1996

Doxycycline as Potential Anti-Cancer Agent.

scientific article published on 13 February 2017

E6 and E7 from human papillomavirus type 16 cooperate to target the PDZ protein Na/H exchange regulatory factor 1.

scientific article

Effects of beta-endorphin and Naloxone on in vitro maturation of bovine oocytes.

scientific article published in October 2002

ErbB2 and the antimetastatic nm23/NDP kinase in regulating serum induced breast cancer invasion

scientific article published on July 2003

Erratum: Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question.

scientific article published on 18 December 2014

Extracellular Matrix Composition Modulates the Responsiveness of Differentiated and Stem Pancreatic Cancer Cells to Lipophilic Derivate of Gemcitabine

scientific article published on 22 December 2020

Extracellular adenine nucleotides regulate Na+/H+ exchanger NHE3 activity in A6-NHE3 transfectants by a cAMP/PKA-dependent mechanism.

scientific article published on August 2002

Extracellular matrix composition modulates PDAC parenchymal and stem cell plasticity and behavior through the secretome.

scientific article

Extracellular matrix degradation via enolase/plasminogen interaction: Evidence for a mechanism conserved in Metazoa.

scientific article published on 5 February 2016

Functional asymmetry of phosphate transport and its regulation in opossum kidney cells: phosphate "adaptation".

scientific article published in October 1991

Functional asymmetry of phosphate transport and its regulation in opossum kidney cells: phosphate transport.

scientific article published on July 1990

Functional expression of the extracellular calcium sensing receptor (CaSR) in equine umbilical cord matrix size-sieved stem cells

scientific article

Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question

scientific article

GnRH receptors in human breast cancer and its contiguous not-involved breast tissue

scientific article published on 01 February 2000

Gonadotrophin releasing hormone (GnRH) receptor and steroid receptors in human uterine leiomyoma, myometrium and endometrium

scientific article

Gonadotropin releasing hormone receptor expression in primary breast cancer: comparison of immunohistochemical, radioligand and Western blot analyses.

scientific article published on September 2002

Growth and trophic factors, pH and the Na+/H+ exchanger in Alzheimer's disease, other neurodegenerative diseases and cancer: new therapeutic possibilities and potential dangers.

scientific article published on February 2007

Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis.

scientific article published on October 2003

Identification, characterization and purification of a 160 kD bumetanide-binding glycoprotein from the rabbit parotid.

scientific article published in November 1993

Intestinal glucose transport and salinity adaptation in a euryhaline teleost

scientific article published in March 1987

Intestinal glycyl-L-phenylalanine and L-phenylalanine transport in a euryhaline teleost

scientific article published on 01 March 1991

Involvement of direct phosphorylation in the regulation of the rat parotid Na(+)-K(+)-2Cl- cotransporter

scientific article published on 01 October 1995

Involvement of nuclear NHERF1 in colorectal cancer progression.

scientific article

KRAS-regulated glutamine metabolism requires UCP2-mediated aspartate transport to support pancreatic cancer growth

scientific article published on 23 November 2020

Localization and quantitative expression of the calcium-sensing receptor protein in human oocytes

scientific article

MED1101: a new dialdehydic compound regulating P2×7 receptor cell surface expression in U937 cells

scientific article published on 15 July 2013

Monocarboxylate Transporters MCT1 and MCT4 Regulate Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells.

scientific article published on 13 January 2016

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

scientific article published on 14 June 2010

NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions.

scientific article published on 28 June 2006

NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains

scientific article

Na+-H+ exchanger, pH regulation and cancer.

scientific article published on January 2013

Na+/H(+)-exchange in A6 cells: polarity and vasopressin regulation

scientific article published on November 1, 1992

Na+/H+ exchanger regulatory factor 1 expression levels in blood and tissue predict breast tumour clinical behaviour

scientific article published on 01 June 2011

Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells

scientific article

Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibro

scientific article published on 3 October 2005

Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes.

scientific article

NaV1.5 Na⁺ channels allosterically regulate the NHE-1 exchanger and promote the activity of breast cancer cell invadopodia

scientific article published on 31 July 2013

Naloxone inhibits A6 cell Na(+)/H(+) exchange by activating protein kinase C via the mobilization of intracellular calcium

scientific article published on 01 January 2001

Paclitaxel induces apoptosis via protein kinase A- and p38 mitogen-activated protein-dependent inhibition of the Na+/H+ exchanger (NHE) NHE isoform 1 in human breast cancer cells

scientific article published on June 2003

Phosphate transport in established renal epithelial cell lines.

scientific article published on January 1990

Phosphorylation of NHERF1 S279 and S301 differentially regulates breast cancer cell phenotype and metastatic organotropism

scientific article published on 13 October 2018

Polarized expression of Na+/H+ exchange activity in LLC-PK1/PKE20 cells: II. Hormonal regulation ⬇️

scientific article published on March 1, 1992

Proline transport by brush-border membrane vesicles of lobster antennal glands

scientific article published on 01 February 1990

Protease activity at invadopodial focal digestive areas is dependent on NHE1-driven acidic pHe.

scientific article published on 13 December 2013

Protein kinase A gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines

scientific article

Proton dynamics in cancer

scientific article published on 15 June 2010

Proton transport inhibitors as potentially selective anticancer drugs.

scientific article published on June 2009

Protons extruded by NHE1: digestive or glue?

scientific article published on 06 March 2008

Pseudomonas aeruginosa reduces the expression of CFTR via post-translational modification of NHERF1.

scientific article published on 5 March 2014

Reciprocal protein kinase A regulatory interactions between cystic fibrosis transmembrane conductance regulator and Na+/H+ exchanger isoform 3 in a renal polarized epithelial cell model.

scientific article

Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion

scientific article published on 01 August 1997

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp.

scientific article published on 15 July 2015

Retracted: HPV16 E7-Dependent Transformation Activates NHE1 through a PKA-RhoA-Iinduced Inhibition of p38alpha

retracted article

RhoA protein expression in primary breast cancers and matched lymphocytes is associated with progression of the disease

scientific article published on 01 July 2008

Role of Stromal Cells in Determining Tumor and Cancer Stem Cell Behaviors and Therapeutic Response

scientific article published on 28 October 2020

Role of pHi, and proton transporters in oncogene-driven neoplastic transformation

scientific article published on 03 February 2014

Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells.

scientific article published on October 2004

Synergy Between Low Dose Metronomic Chemotherapy and the pH-centered Approach Against Cancer ⬇️

scientific article published on 31 October 2019

The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer

scientific article published on 07 April 2020

The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells.

scientific article

The Na+-H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells

scientific article

The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH

scientific article published on 11 July 2020

The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management

scientific article published on 22 February 2019

The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela

scientific article published on 28 July 2019

The complexity of targeting EGFR signalling in cancer: from expression to turnover

scientific article published on 23 June 2006

The extracellular calcium-sensing receptor is expressed in the cumulus-oocyte complex in mammals and modulates oocyte meiotic maturation.

scientific article published on 3 June 2009

The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.

scientific article

The role of pH dynamics and the Na+/H+ antiporter in the etiopathogenesis and treatment of cancer. Two faces of the same coin--one single nature

scientific article

The role of proton dynamics in the development and maintenance of multidrug resistance in cancer

scientific article

The scaffolding protein NHERF1 sensitizes EGFR-dependent tumor growth, motility and invadopodia function to gefitinib treatment in breast cancer cells.

scientific article published on 19 December 2014

Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.

scientific article published on 9 May 2014

[The estimation of LHRH receptors in the tissue of human leiomyoma, myometrium and endometrium]

scientific article published on 01 October 1994

pH regulators in invadosomal functioning: proton delivery for matrix tasting

scientific article published on 04 June 2012

pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

scientific article published on 02 September 2020

ß1 integrin binding phosphorylates ezrin at T567 to activate a lipid raft signalsome driving invadopodia activity and invasion

scientific article

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