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List of works by Angelo De Milito

A drug screening assay on cancer cells chronically adapted to acidosis

scientific article published on 25 September 2018

A rationale for the use of proton pump inhibitors as antineoplastic agents.

scientific article published on January 2012

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine: implications for cancer therapies.

scientific article published on 31 January 2014

Altered distribution of natural killer cell subsets identified by CD56, CD27 and CD70 in primary and chronic human immunodeficiency virus-1 infection

scientific article

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance.

scientific article published on 22 August 2016

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism

scientific article published on 03 October 2018

Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer

scientific article

Antiretroviral therapy with protease inhibitors in human immunodeficiency virus type 1- and human herpesvirus 8-coinfected patients

scientific article published in February 1999

Autophagy is a protective mechanism for human melanoma cells under acidic stress

scientific article

B cell immunopathology during HIV-1 infection: lessons to learn for HIV-1 vaccine design.

scientific article published on 17 December 2007

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

scientific article published on 04 September 2014

Clinical evaluation of an in-house reverse transcription-competitive PCR for quantitation of human immunodeficiency virus type 1 RNA in plasma

scientific article

Concordance between polymerase chain reaction and antibody detection in the diagnosis of human immunodeficiency virus type 1 infection

scientific article published in November 1995

Current chemotherapy protocols for childhood acute lymphoblastic leukemia induce loss of humoral immunity to viral vaccination antigens

scientific article published in June 2002

Cytostatic therapy reduces the immune defense. Children treated for leukemia have impaired immunity against measles and rubella

scientific article published on 01 November 2000

Detection of human herpesviruses 6 and 7 in heart transplant recipients by a multiplex polymerase chain reaction method

scientific article published on 01 February 1998

Effects of potent antiretroviral therapy on the immune activation marker soluble CD27 in patients infected with HIV-1 subtypes A-D.

scientific article published in March 2004

Elevated levels of soluble Fas and Fas ligand in cerebrospinal fluid of patients with AIDS dementia complex.

scientific article published in March 2001

Eradicating Quiescent Tumor Cells by Targeting Mitochondrial Bioenergetics.

scientific article published on 11 November 2016

Evaluation of cell-free and cell-associated peripheral blood human immunodeficiency virus type 1 RNA response to antiretroviral therapy

scientific article published in February 1999

Evaluation of the presence of 2-LTR HIV-1 unintegrated DNA as a simple molecular predictor of disease progression

scientific article published in May 1997

Expression of CD27-CD70 on early B cell progenitors in the bone marrow: implication for diagnosis and therapy of childhood ALL.

scientific article published in December 2005

FasL and TRAIL induce epidermal apoptosis and skin ulceration upon exposure to Leishmania major.

scientific article published on January 2007

Fatal herpesvirus 6 encephalitis after unrelated bone marrow transplant

scientific article published on 01 August 1998

Genotypic resistance to zidovudine as a predictor of failure of subsequent therapy with human immunodeficiency virus type-1 nucleoside reverse-transcriptase inhibitors

scientific article published in April 1999

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HIV-associated malignant lymphomas in Kenya (Equatorial Africa)

scientific article published in November 1998

High Plasma Levels of Soluble Fas in HIV Type 1-Infected Subjects Are Not Normalized during Highly Active Antiretroviral Therapy

article

High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients

scientific article

Human immunodeficiency virus-1 infection, homosexuality, and Kaposi-associated herpes-like DNA in peripheral blood mononuclear cells

scientific article published in April 1996

Increased reliability of selective PCR by using additionally mutated primers and a commercialTaq DNA polymerase enhancer

scientific article published on 01 April 1995

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti-PD-1/PD-L1 immunotherapy

scientific article published on 29 April 2020

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

scientific article published on January 1, 2013

Lack of evidence of HHV-8 DNA in blood cells from heart transplant recipients

article

Lighting up the fire in cold tumors to improve cancer immunotherapy by blocking the activity of the autophagy-related protein PIK3C3/VPS34

scientific article published on 05 September 2020

Long-read direct infrared sequencing of crude PCR products for prediction of resistance to HIV-1 reverse transcriptase and protease inhibitors

scientific article

Loss of IL-7Ralpha is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients

article

Loss of memory (CD27) B lymphocytes in HIV-1 infection.

scientific article published in May 2001

Loss of memory B cells impairs maintenance of long-term serologic memory during HIV-1 infection

scientific article published on 27 April 2006

Low frequency of plasma nerve-growth factor detection is associated with death of memory B lymphocytes in HIV-1 infection

article

Low human immunodeficiency virus type 1 (HIV-1) DNA burden as a major cause for failure to detect HIV-1 DNA in clinical specimens by PCR.

scientific article

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

article

Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection

scientific article (publication date: 15 March 2004)

Metabolism and microenvironment in cancer plasticity.

scientific article published on 15 February 2016

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes

scientific article

Nerve growth factor released by CD40 ligand-transfected l cells: implications for functional and phenotypic studies on CD40+ cells

scientific article published on 01 December 1998

P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.

scientific article

Pathobiology and therapeutic implications of tumor acidosis

scientific article published on 28 December 2016

Pleiotropic function of ezrin in human metastatic melanomas.

scientific article published in June 2009

Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection.

scientific article published in April 2007

Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions

scientific article published in November 2005

Proton channels and exchangers in cancer

scientific article

Proton dynamics in cancer

scientific article published on 15 June 2010

Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells

scientific article

Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species.

scientific article published on June 2007

Proton pump inhibitors may reduce tumour resistance

scientific article published in June 2005

STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes

scientific article published in Scientific Reports

Soluble CD23 in cerebrospinal fluid: a marker of AIDS-related non-Hodgkin's lymphoma in the brain

scientific article published in June 2001

Soluble CD27 induces IgG production through activation of antigen-primed B cells

scientific article published on 14 September 2011

Spheroid-based 3D cell cultures identify salinomycin as a promising drug for the treatment of chondrosarcoma

article

Surrogate markers as a guide to evaluate response to antiretroviral therapy.

scientific article

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

scientific article published on 13 November 2015

Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib

scientific article published on 25 July 2018

The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells

scientific article

The acidity of the tumor microenvironment is a mechanism of immune escape that can be overcome by proton pump inhibitors.

scientific article published on January 2013

The human homologue of Dictyostelium discoideum phg1A is expressed by human metastatic melanoma cells

scientific journal article

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

scientific article published on 7 December 2011

The plant alkaloid voacamine induces apoptosis-independent autophagic cell death on both sensitive and multidrug resistant human osteosarcoma cells.

scientific article published on 9 November 2008

Therapeutic implications of tumor interstitial acidification.

scientific article published on 7 February 2017

Tumor acidity, chemoresistance and proton pump inhibitors.

scientific article

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells

scientific article published on 27 May 2016

Zidovudine resistance mutations and human immunodeficiency virus type 1 DNA burden: longitudinal evaluation of six patients under treatment

scientific article published in November 1996

pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity

scientific article published on July 2010