List of works - Ellen G. Duysen

Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine

scientific article

Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice

scientific article published on 06 September 2007

Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon

scientific article published on October 28, 2010

Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.

scientific article published on 19 June 2009

Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry

scientific article published on 3 November 2004

Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice

scientific article

Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice

scientific journal article

Assessment of tribal bison worker hazards using trusted research facilitators

journal article published in 2017

Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma

scientific article

Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice

scientific article published on 16 October 2007

Comparison of agricultural injuries reported in the media and census of fatal occupational injuries

journal article published in 2019

Contributions of selective knockout studies to understanding cholinesterase disposition and function.

scientific article

Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse.

scientific article published on 21 October 2005

Dietary energy restriction does not inhibit pancreatic carcinogenesis by N-nitrosobis-2-(oxopropyl)amine in the Syrian hamster

scientific article published on 01 November 1997

Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse.

scientific article published in January 2010

Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity

scientific journal article

Gene transfer of acetylcholinesterase protects the knockout mouse from the toxicity of DFP.

scientific article published in January 2006

Gene-Delivered Butyrylcholinesterase Is Prophylactic against the Toxicity of Chemical Warfare Nerve Agents and Organophosphorus Compounds ⬇️

scientific article published on December 28, 2010

Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors

scientific journal article

Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice

scientific article

Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons

scientific article published on 2 July 2011

Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice

scientific article published on 26 January 2005

Mass spectrometry identifies multiple organophosphorylated sites on tubulin

scientific article published on 24 July 2009

Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry ⬇️

scientific article published on March 8, 2012

Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents.

scientific article

Phenotype Comparison of Three Acetylcholinesterase Knockout Strains

scientific article published on 01 January 2006

Polyclonal Antibody to Soman-Tyrosine ⬇️

scientific article published on March 21, 2013

Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies ⬇️

scientific article published on September 7, 2011

Production of the butyrylcholinesterase knockout mouse.

scientific article

Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans

scientific article published on 3 May 2011

Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase

scientific article

Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice

scientific article

Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice

scientific article published in March 2003

Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse

scientific article published in July 2002

Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.

scientific article published in May 2004

Role of Acetylcholinesterase on the Structure and Function of Cholinergic Synapses: Insights Gained from Studies on Knockout Mice

scientific article published on 03 May 2011

Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants

scientific article

Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmis

scientific article published on 2 December 2006

Social marketing campaign promoting the use of respiratory protection devices among farmers.

journal article published in 2014

The butyrylcholinesterase knockout mouse is obese on a high-fat diet

scientific article published on 22 March 2008

Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase

scientific article published on 07 March 2008

Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity

scientific article

List of works by Ellen G. Duysen

Acetylcholinesterase knockouts establish central cholinergic pathways and can use butyrylcholinesterase to hydrolyze acetylcholine

Adaptation to excess acetylcholine by downregulation of adrenoceptors and muscarinic receptors in lungs of acetylcholinesterase knockout mice

Adenovirus-mediated human paraoxonase1 gene transfer to provide protection against the toxicity of the organophosphorus pesticide toxicant diazoxon

Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.

Albumin, a new biomarker of organophosphorus toxicant exposure, identified by mass spectrometry

Altered hippocampal muscarinic receptors in acetylcholinesterase-deficient mice

Altered striatal function and muscarinic cholinergic receptors in acetylcholinesterase knockout mice

Assessment of tribal bison worker hazards using trusted research facilitators

Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma

Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice

Comparison of agricultural injuries reported in the media and census of fatal occupational injuries

Contributions of selective knockout studies to understanding cholinesterase disposition and function.

Delivery of human acetylcholinesterase by adeno-associated virus to the acetylcholinesterase knockout mouse.

Dietary energy restriction does not inhibit pancreatic carcinogenesis by N-nitrosobis-2-(oxopropyl)amine in the Syrian hamster

Drastic decrease in dopamine receptor levels in the striatum of acetylcholinesterase knock-out mouse.

Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity

Gene transfer of acetylcholinesterase protects the knockout mouse from the toxicity of DFP.

Gene-Delivered Butyrylcholinesterase Is Prophylactic against the Toxicity of Chemical Warfare Nerve Agents and Organophosphorus Compounds ⬇️

Impaired formation of the inner retina in an AChE knockout mouse results in degeneration of all photoreceptors

Increased hepatotoxicity and cardiac fibrosis in cocaine-treated butyrylcholinesterase knockout mice

Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons

Life without acetylcholinesterase: the implications of cholinesterase inhibitor toxicity in AChE-knockout mice

Mass spectrometry identifies multiple organophosphorylated sites on tubulin

Mice treated with a nontoxic dose of chlorpyrifos oxon have diethoxyphosphotyrosine labeled proteins in blood up to 4 days post exposure, detected by mass spectrometry ⬇️

Mice treated with chlorpyrifos or chlorpyrifos oxon have organophosphorylated tubulin in the brain and disrupted microtubule structures, suggesting a role for tubulin in neurotoxicity associated with exposure to organophosphorus agents.

Phenotype Comparison of Three Acetylcholinesterase Knockout Strains

Polyclonal Antibody to Soman-Tyrosine ⬇️

Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies ⬇️

Production of the butyrylcholinesterase knockout mouse.

Prolonged toxic effects after cocaine challenge in butyrylcholinesterase/plasma carboxylesterase double knockout mice: a model for butyrylcholinesterase-deficient humans

Protection from the toxicity of diisopropylfluorophosphate by adeno-associated virus expressing acetylcholinesterase

Reduced acetylcholine receptor density, morphological remodeling, and butyrylcholinesterase activity can sustain muscle function in acetylcholinesterase knockout mice

Regulation of muscarinic acetylcholine receptor function in acetylcholinesterase knockout mice

Rescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse

Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase.

Role of Acetylcholinesterase on the Structure and Function of Cholinergic Synapses: Insights Gained from Studies on Knockout Mice

Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants

Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmis

Social marketing campaign promoting the use of respiratory protection devices among farmers.

The butyrylcholinesterase knockout mouse is obese on a high-fat diet

Whole body and tissue imaging of the butyrylcholinesterase knockout mouse injected with near infrared dye labeled butyrylcholinesterase

Wild-type and A328W mutant human butyrylcholinesterase tetramers expressed in Chinese hamster ovary cells have a 16-hour half-life in the circulation and protect mice from cocaine toxicity