List of works - Kevin M Crofton

A qualitative retrospective analysis of positive control data in developmental neurotoxicity studies.

scientific article

A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426

scientific article published on 12 August 2008

Accumulation of PBDE-47 in primary cultures of rat neocortical cells

scientific article

Acute effects of amitraz on the acoustic startle response and motor activity

article

Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture

scientific article published on 10 June 2011

Administration of 3,3'-iminodipropionitrile to the rat results in region-dependent damage to the central nervous system at levels above the brain stem.

scientific article published in June 1993

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

scientific article published in January 2012

Age-dependent differences in the susceptibility of rats to deltamethrin

scientific article published in May 1994

Alterations in flash evoked potentials (FEPs) in rats produced by 3,3′-iminodipropionitrile (IDPN),

scientific article published on 01 November 1995

An animal model of marginal iodine deficiency during development: the thyroid axis and neurodevelopmental outcome

scientific article

An empirical approach to sufficient similarity: combining exposure data and mixtures toxicology data

scientific article

An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models

scientific article published in January 1990

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

scientific article

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).

scientific article published on 27 September 2014

Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols

scientific article published in March 2004

Assessment of offspring development and behavior following gestational exposure to inhaled methanol in the rat.

scientific article

Auditory deficits and motor dysfunction following iminodipropionitrile administration in the rat.

scientific article published in November 1991

Behavioral development following daily episodes of mother-infant separation in the rat.

scientific article published in October 1992

Behavioral test methods workshop

scientific article published on 26 April 2005

Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009.

scientific article published on 17 February 2010

Bromate: concern for developmental neurotoxicity?

scientific article published on 3 March 2006

Characterization of Disulfoton-Induced Behavioral and Neurochemical Effects Following Repeated Exposure

article

Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure

scientific article published in February 1993

Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole.

scientific article published on January 1996

Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats

scientific article published on 01 May 1996

Comments on: 'Perinatal toxicity of cyfluthrin in mice: developmental and behavioral effects' by Soni and colleagues.

scientific article published in August 2011

Comments on: Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings [Johri et al. Toxicol Appl Pharmacol. 214:279-289, 2006].

scientific article published on 28 October 2006

Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners

scientific article published in August 2002

Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis

scientific article

Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes

scientific article published on 16 May 2007

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

scientific article published on 12 February 2018

Conversion of Developmental Neurotoxicity (DNT) information into a structure-searchable relational database

Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat.

scientific article

Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity

scientific article published on 01 January 2019

Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

scientific article published on 10 February 2011

Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat.

scientific article published on 17 August 2013

Current perspectives on the use of alternative species in human health and ecological hazard assessments

scientific article

Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study

scientific article published in January 2011

Determination of acrylamide in rat serum and sciatic nerve by gas chromatography-electron-capture detection

scientific article published on 01 September 1993

Development of a thyroperoxidase inhibition assay for high-throughput screening.

scientific article published on 14 January 2014

Developmental Neurotoxicity: Evaluation of Testing Procedures with Methylazoxymethanol and Methylmercury

Developmental delays in exploration and locomotor activity in male rats exposed to low level lead

scientific article published in March 1980

Developmental disruption of thyroid hormone: correlations with hearing dysfunction in rats

scientific article published in December 2004

Developmental exposure to Aroclor 1254 produces low-frequency alterations in adult rat brainstem auditory evoked responses

scientific article published in September 1996

Developmental exposure to a commercial PCB mixture (Aroclor 1254) produces a persistent impairment in long-term potentiation in the rat dentate gyrus in vivo

scientific article published in December 1999

Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption

scientific article published in March 2002

Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats

scientific article published in November 1995

Developmental neurotoxicity following neonatal exposure to 3,3'-iminodipropionitrile in the rat.

scientific article published in March 1993

Developmental neurotoxicity guideline study: issues with methodology, evaluation and regulation

scientific article published on September 2012

Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs

scientific article

Developmental neurotoxicity testing: a path forward

scientific article published on September 2012

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.

scientific article published on January 2011

Developmental neurotoxicity: evaluation of testing procedures with methylazoxymethanol and methylmercury

scientific article published in October 1994

Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats

scientific article

Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action

scientific article

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

scientific article

Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat.

scientific article

Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3'-iminodipropionitrile in male rats

scientific article published in June 1997

Effects of 3,3'-iminodipropionitrile on acquisition and performance of spatial tasks in rats.

scientific article published in November 1994

Effects of 3,3'-iminodipropionitrile on the peripheral structures of the rat visual system

article

Effects of developmental hypothyroidism on auditory and motor function in the rat.

scientific article published in November 1995

Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats

scientific article published in May 2001

Effects of toluene inhalation on detection of auditory signals in rats

scientific article published in March 1994

Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat.

scientific article published in September 1984

Enhanced neurotoxicity of 3,3'-iminodipropionitrile following carbon tetrachloride pretreatment in the rat.

scientific article published on January 1991

Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats.

scientific article published on 12 March 2014

Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids

scientific article

Evaluating the effects of acrylamide and 3,3'-iminopropionitrile (IDPN), using behavioral (functional observational battery and motor activity) and neuropathological end points

scientific article published on 01 August 1992

Evaluation of iodide deficiency in the lactating rat and pup using a biologically based dose-response model

scientific article published on 3 January 2013

Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments

scientific article

Evidence for dose-additive effects of pyrethroids on motor activity in rats

scientific article

Evidence for monoaminergic involvement in triadimefon-induced hyperactivity

scientific article published in January 1989

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

scientific article published on 27 July 2013

Expanding the test set: Chemicals with potential to disrupt mammalian brain development

scientific article published on 14 October 2015

Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254.

scientific article published in November 2001

Gestational-lactational exposure to Aroclor 1254 impairs radial-arm maze performance in male rats.

scientific article published in September 2000

Hearing loss following exposure during development to polychlorinated biphenyls: a cochlear site of action

scientific article published in June 2000

Hyperactivity induced by triadimefon, a triazole fungicide*1

scientific article published on 01 April 1988

Identification and interpretation of developmental neurotoxicity effects: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints

scientific article published on 03 August 2007

Implications of the use of neonatal birth weight, growth, viability, and survival data for predicting developmental neurotoxicity: a survey of the literature.

scientific article published on May 1995

In utero and lactational exposure to bisphenol A, in contrast to ethinyl estradiol, does not alter sexually dimorphic behavior, puberty, fertility, and anatomy of female LE rats

scientific article

In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast programme

scientific article published on 22 April 2014

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis

scientific article

In vivo acute exposure to polychlorinated biphenyls: effects on free and total thyroxine in rats.

scientific article published in September 2009

Influence of dosing volume on the neurotoxicity of bifenthrin

scientific article published on 24 January 2007

Inhalational exposure to carbonyl sulfide produces altered brainstem auditory and somatosensory-evoked potentials in Fischer 344N rats

scientific article published in November 2006

Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High-Throughput Screening Assays for the Estrogen Receptor.

scientific article published on 13 August 2015

Interlaboratory comparison of motor activity experiments: implications for neurotoxicological assessments

scientific article published in November 1991

International Regulatory and Scientific Effort for Improved Developmental Neurotoxicity Testing

scientific article published on 01 January 2019

International STakeholder NETwork (ISTNET) for creating a developmental neurotoxicity testing (DNT) roadmap for regulatory purposes

scientific article published in January 2014

International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes

scientific article

Juvenile toxicity testing protocols for chemicals

scientific article published on 4 May 2012

Learning and memory deficits in rats following exposure to 3,3'-iminodipropionitrile.

scientific article published in September 1990

Low level lead (Pb) exposure produces learning deficits in young rat pups.

scientific article published in May 1982

Low-dose effects of ammonium perchlorate on the hypothalamic-pituitary-thyroid axis of adult male rats pretreated with PCB126.

scientific article published on 22 March 2007

Low-frequency hearing loss following perinatal exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in rats

scientific article published in May 1999

Marginal iodide deficiency and thyroid function: dose-response analysis for quantitative pharmacokinetic modeling

scientific article

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

scientific article published on 27 February 2013

Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making

journal article published in 2008

Mid-frequency hearing loss in rats following inhalation exposure to trichloroethylene: evidence from reflex modification audiometry

scientific article published in November 1993

Mode of action: developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil

scientific article

Mode of action: neurotoxicity induced by thyroid hormone disruption during development--hearing loss resulting from exposure to PHAHs

scientific article

NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine

scientific article

NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of methylphenidate

scientific article

OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes.

scientific article published in January 2017

Olfactory toxicity of beta,beta'-iminodipropionitrile in the rat.

scientific article published in December 1992

Optimal design for the precise estimation of an interaction threshold: the impact of exposure to a mixture of 18 polyhalogenated aromatic hydrocarbons

scientific article

Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data

scientific article

PCBs, thyroid hormones, and ototoxicity in rats: cross-fostering experiments demonstrate the impact of postnatal lactation exposure

scientific article published in September 2000

Perinatal exposure to Aroclor 1254 impairs distortion product otoacoustic emissions (DPOAEs) in rats

scientific article published in August 2002

Postnatal evaluation of prenatal exposure to p-xylene in the rat.

scientific article published in December 1986

Predictive modeling of a mixture of thyroid hormone disrupting chemicals that affect production and clearance of thyroxine

scientific article published in September 2009

Prenatal or postnatal exposure to bis(tri-n-butyltin)oxide in the rat: postnatal evaluation of teratology and behavior

scientific article

Putative adverse outcome pathways relevant to neurotoxicity

scientific article

Pyrethroid effects on schedule-controlled behavior: time and dosage relationships.

scientific article published in September 1987

Pyrethroid insecticides and radioligand displacement from the GABA receptor chloride ionophore complex.

scientific article published in February 1987

Pyrethroid insecticides and the gamma-aminobutyric acidA receptor complex: motor activity and the acoustic startle response in the rat.

scientific article published in December 1987

Pyrethroids and enhanced inhibition in the hippocampus of the rat.

scientific article published in January 1989

Re: The use of uncertainty factors in estimating health risks.

scientific article published in July 1996

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

scientific article published on 23 February 2018

Reflex modification and the detection of toxicant-induced auditory dysfunction.

scientific article published on September 1990

Relationships between Biomarkers of Exposure and Neurological Effects in a Group of Workers Exposed to Acrylamide

scientific article published on 01 June 1994

Relative potencies for acute effects of pyrethroids on motor function in rats

scientific article

Risk assessment of combined exposure to multiple chemicals: A WHO/IPCS framework

scientific article published on 02 April 2011

Schedule-controlled behavior in rats exposed perinatally to the PCB mixture Aroclor 1254.

scientific article published in July 2002

Screening methods for thyroid hormone disruptors.

scientific article

Setting exposure standards: a decision process.

scientific article

Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in Young Long-Evans rats

scientific article

Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine

scientific article published on 27 April 2007

Solvent-induced ototoxicity in rats: an atypical selective mid-frequency hearing deficit

scientific article published in October 1994

Spatial Reversal Learning in Aroclor 1254-Exposed Rats: Sex-Specific Deficits in Associative Ability and Inhibitory Control

article

Spatial learning and long-term potentiation in the dentate gyrus of the hippocampus in animals developmentally exposed to Aroclor 1254.

scientific article published in September 2000

Splice variant specific increase in Ca2+/calmodulin-dependent protein kinase 1-gamma mRNA expression in response to acute pyrethroid exposure

scientific article published in May 2010

The Ototoxicity of Trichloroethylene: Extrapolation and Relevance of High-Concentration, Short-Duration Animal Exposure Data, ⬇️

scientific article published on July 1, 1997

The effects of 2,4-dithiobiuret on sensory and motor function*1

scientific article published on 01 April 1991

The effects of triclosan on puberty and thyroid hormones in male Wistar rats

scientific article

The effects of type I and II pyrethroids on motor activity and the acoustic startle response in the rat.

scientific article published in May 1988

The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators

scientific article published on 25 February 2007

The human toxome project

scientific article

The impact of dose rate on the neurotoxicity of acrylamide: the interaction of administered dose, target tissue concentrations, tissue damage, and functional effects

scientific article published in July 1996

The impact of exposure to a mixture of eighteen polyhalogenated aromatic hydrocarbons on thyroid function: Estimation of an interaction threshold

The next generation of risk assessment multi-year study - highlights of findings, applications to risk assessment, and future directions

journal article published in 2016

The ototoxicity of 3,3'-iminodipropionitrile: functional and morphological evidence of cochlear damage.

scientific article published on November 1994

The sensitivity to 3,3'-iminodipropionitrile differs for high- and midfrequency hearing loss in the developing rat.

scientific article published in September 1993

Thioridazine and the neuroleptic radioreceptor assay

scientific article published in June 1984

Thyroid disrupting chemicals: mechanisms and mixtures

scientific article published on 22 January 2008

Thyroid-disrupting chemicals: interpreting upstream biomarkers of adverse outcomes

scientific article published on 12 February 2009

Thyroid-hormone-disrupting chemicals: evidence for dose-dependent additivity or synergism

scientific article

Thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to Aroclor 1254 in rats

scientific article published in September 1998

Time and concentration dependent accumulation of [3H]-deltamethrin in Xenopus laevis oocytes

scientific article

ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology

scientific article (publication date: 15 August 2016)

Transcriptional response of rat frontal cortex following acute in vivo exposure to the pyrethroid insecticides permethrin and deltamethrin

scientific article

Triadimefon, a triazole fungicide, induces stereotyped behavior and alters monoamine metabolism in rats.

scientific article published on March 1990

Trimethyltin effects on auditory function and cochlear morphology

scientific article published in August 1990

Undertaking positive control studies as part of developmental neurotoxicity testing: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints

scientific article published on 15 June 2007

Use of Biological Markers in the Quantitative Assessment of Neurotoxic Risk

Use of environmental challenges in behavioral toxicology

scientific article published on 01 December 1983

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

scientific article

Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals.

scientific article published on 28 September 2012

Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor function in the rat.

scientific article published in July 1995

Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies

scientific article published on 6 February 2007

t4 workshop report: Pathways of Toxicity

scientific article (publication date: 2014)

List of works by Kevin M Crofton

A qualitative retrospective analysis of positive control data in developmental neurotoxicity studies.

A retrospective performance assessment of the developmental neurotoxicity study in support of OECD test guideline 426

Accumulation of PBDE-47 in primary cultures of rat neocortical cells

Acute effects of amitraz on the acoustic startle response and motor activity

Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture

Administration of 3,3'-iminodipropionitrile to the rat results in region-dependent damage to the central nervous system at levels above the brain stem.

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

Age-dependent differences in the susceptibility of rats to deltamethrin

Alterations in flash evoked potentials (FEPs) in rats produced by 3,3′-iminodipropionitrile (IDPN),

An animal model of marginal iodine deficiency during development: the thyroid axis and neurodevelopmental outcome

An empirical approach to sufficient similarity: combining exposure data and mixtures toxicology data

An examination of the proconvulsant actions of pyrethroid insecticides using pentylenetetrazol and amygdala kindling seizure models

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).

Assessment of DE-71, a commercial polybrominated diphenyl ether (PBDE) mixture, in the EDSP male and female pubertal protocols

Assessment of offspring development and behavior following gestational exposure to inhaled methanol in the rat.

Auditory deficits and motor dysfunction following iminodipropionitrile administration in the rat.

Behavioral development following daily episodes of mother-infant separation in the rat.

Behavioral test methods workshop

Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009.

Bromate: concern for developmental neurotoxicity?

Characterization of Disulfoton-Induced Behavioral and Neurochemical Effects Following Repeated Exposure

Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure

Characterization of olfactory deficits in the rat following administration of 2,6-dichlorobenzonitrile (dichlobenil), 3,3'-iminodipropionitrile, or methimazole.

Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats

Comments on: 'Perinatal toxicity of cyfluthrin in mice: developmental and behavioral effects' by Soni and colleagues.

Comments on: Effect of prenatal exposure of deltamethrin on the ontogeny of xenobiotic metabolizing cytochrome P450s in the brain and liver of offsprings [Johri et al. Toxicol Appl Pharmacol. 214:279-289, 2006].

Comparative responsiveness of hypothyroxinemia and hepatic enzyme induction in Long-Evans rats versus C57BL/6J mice exposed to TCDD-like and phenobarbital-like polychlorinated biphenyl congeners

Comparison of PC12 and cerebellar granule cell cultures for evaluating neurite outgrowth using high content analysis

Concentration-dependent accumulation of [3H]-deltamethrin in sodium channel Nav1.2/beta1 expressing Xenopus laevis oocytes

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Conversion of Developmental Neurotoxicity (DNT) information into a structure-searchable relational database

Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat.

Corrigendum to Recommendation on test readiness criteria for new approach methods in toxicology: exemplified for developmental neurotoxicity

Critical analysis of literature on low-dose synergy for use in screening chemical mixtures for risk assessment

Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat.

Current perspectives on the use of alternative species in human health and ecological hazard assessments

Defining and modeling known adverse outcome pathways: Domoic acid and neuronal signaling as a case study

Determination of acrylamide in rat serum and sciatic nerve by gas chromatography-electron-capture detection

Development of a thyroperoxidase inhibition assay for high-throughput screening.

Developmental Neurotoxicity: Evaluation of Testing Procedures with Methylazoxymethanol and Methylmercury

Developmental delays in exploration and locomotor activity in male rats exposed to low level lead

Developmental disruption of thyroid hormone: correlations with hearing dysfunction in rats

Developmental exposure to Aroclor 1254 produces low-frequency alterations in adult rat brainstem auditory evoked responses

Developmental exposure to a commercial PCB mixture (Aroclor 1254) produces a persistent impairment in long-term potentiation in the rat dentate gyrus in vivo

Developmental exposure to brominated diphenyl ethers results in thyroid hormone disruption

Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats

Developmental neurotoxicity following neonatal exposure to 3,3'-iminodipropionitrile in the rat.

Developmental neurotoxicity guideline study: issues with methodology, evaluation and regulation

Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs

Developmental neurotoxicity testing: a path forward

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.

Developmental neurotoxicity: evaluation of testing procedures with methylazoxymethanol and methylmercury

Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats

Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat.

Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3'-iminodipropionitrile in male rats

Effects of 3,3'-iminodipropionitrile on acquisition and performance of spatial tasks in rats.

Effects of 3,3'-iminodipropionitrile on the peripheral structures of the rat visual system

Effects of developmental hypothyroidism on auditory and motor function in the rat.

Effects of short-term in vivo exposure to polybrominated diphenyl ethers on thyroid hormones and hepatic enzyme activities in weanling rats

Effects of toluene inhalation on detection of auditory signals in rats

Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat.

Enhanced neurotoxicity of 3,3'-iminodipropionitrile following carbon tetrachloride pretreatment in the rat.

Environmentally relevant mixing ratios in cumulative assessments: a study of the kinetics of pyrethroids and their ester cleavage metabolites in blood and brain; and the effect of a pyrethroid mixture on the motor activity of rats.

Environmentally relevant mixtures in cumulative assessments: an acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids

Evaluating the effects of acrylamide and 3,3'-iminopropionitrile (IDPN), using behavioral (functional observational battery and motor activity) and neuropathological end points

Evaluation of iodide deficiency in the lactating rat and pup using a biologically based dose-response model

Evaluation of the ToxRTool's ability to rate the reliability of toxicological data for human health hazard assessments

Evidence for dose-additive effects of pyrethroids on motor activity in rats

Evidence for monoaminergic involvement in triadimefon-induced hyperactivity

Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors

Expanding the test set: Chemicals with potential to disrupt mammalian brain development

Flash-, somatosensory-, and peripheral nerve-evoked potentials in rats perinatally exposed to Aroclor 1254.

Gestational-lactational exposure to Aroclor 1254 impairs radial-arm maze performance in male rats.

Hearing loss following exposure during development to polychlorinated biphenyls: a cochlear site of action

Hyperactivity induced by triadimefon, a triazole fungicide*1