List of works - Jennifer Venhorst

A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats.

scientific article published on 4 September 2012

Assessment of a novel scoring method based on solvent accessible surface area descriptors

scientific article published in April 2010

Assessment of scaffold hopping efficiency by use of molecular interaction fingerprints

scientific article published in May 2008

Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors.

scientific article published on 13 May 2011

Design of a high fragment efficiency library by molecular graph theory

scientific article

Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3.

scientific article published on 17 January 2015

Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: alternative approaches.

scientific article

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

scientific article published on January 2003

Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor.

scientific article

Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase.

scientific article

N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT₆R) antagonists with unique structural features.

scientific article published on 26 September 2011

Oncostatin M: Risks and benefits of a Novel Therapeutic Target for Atherosclerosis

scientific article published in 2022

Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket

scientific article

Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection

scientific article published on 01 July 1997

Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates

scientific article

Target–drug interactions: first principles and their application to drug discovery ⬇️

scientific article published on July 12, 2011

The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor.

scientific article published on August 1995

The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment

scientific article published on 21 June 2016

Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats

scientific article published on 3 July 2011

List of works by Jennifer Venhorst

A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats.

Assessment of a novel scoring method based on solvent accessible surface area descriptors

Assessment of scaffold hopping efficiency by use of molecular interaction fingerprints

Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors.

Design of a high fragment efficiency library by molecular graph theory

Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3.

Hazard assessment of nitrosamine and nitramine by-products of amine-based CCS: alternative approaches.

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor.

Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase.

N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT₆R) antagonists with unique structural features.

Oncostatin M: Risks and benefits of a Novel Therapeutic Target for Atherosclerosis

Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket

Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection

Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates

Target–drug interactions: first principles and their application to drug discovery ⬇️

The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor.

The selective 5-HT6 receptor antagonist SLV has putative cognitive- and social interaction enhancing properties in rodent models of cognitive impairment

Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats