List of works - David M. Reif

A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish

scientific article (publication date: 2017)

A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

scientific article (publication date: 21 August 2016)

A comparison of analytical methods for genetic association studies

scientific article published in December 2008

A computational model predicting disruption of blood vessel development

scientific article

A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades.

scientific article

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

scientific article published on 18 January 2011

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database

scientific article (publication date: October 2016)

Advancing toxicology research using in vivo high throughput toxicology with small fish models

scientific article published on 21 June 2016

Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure.

scientific article published on 27 April 2016

Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

scientific article

An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines

scientific article

Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity

scientific article

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

scientific article

Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years

article

Bayesian matrix completion for hypothesis testing

scientific article published in 2023

Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi.

scientific article

Children's Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals

scientific article published on 11 November 2020

Combinatorial pharmacogenetics

scientific article published in November 2005

Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates

scientific article published on 27 January 2009

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging

scientific article published on 27 June 2013

Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing

scientific article

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays.

scientific article

Cytokine expression patterns associated with systemic adverse events following smallpox immunization

scientific article

Data-driven asthma endotypes defined from blood biomarker and gene expression data

scientific article

Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes.

scientific article

Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases

scientific article published on 16 July 2019

Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate

scientific article published on 17 September 2013

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

scientific article

Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes.

scientific article published on 20 September 2016

Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure

article

Endocrine profiling and prioritization of environmental chemicals using ToxCast data

scientific article

Environmental impact on vascular development predicted by high-throughput screening

scientific article

Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay

scientific article

Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population

scientific article

Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership

scientific article

Exploratory Visual Analysis of statistical results from microarray experiments comparing high and low grade glioma

scientific article published on April 2007

Exploratory visual analysis of pharmacogenomic results.

scientific article

Feature Selection using a Random Forests Classifier for the Integrated Analysis of Multiple Data Types

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka, Oryzias latipes.

scientific article published on 15 November 2016

Genetic basis for adverse events after smallpox vaccination

scientific article published on July 2008

HGBEnviroScreen: Enabling Community Action through Data Integration in the Houston-Galveston-Brazoria Region

scientific article published on 11 February 2020

Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals

scientific article published on 7 January 2014

High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes

scientific article

High-throughput models for exposure-based chemical prioritization in the ExpoCast project

scientific article published on 11 July 2013

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study.

scientific article

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

scientific article

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis

scientific article

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

scientific article

Inappropriate Citation of Vaccine Article

scientific article published on 03 June 2019

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

article

Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina.

scientific article

Incorporating exposure information into the toxicological prioritization index decision support framework

scientific article published on 2 August 2012

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

scientific article published on 16 July 2010

Integrated analysis of genetic, genomic and proteomic data

scientific article

Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish

Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways

scientific article published on 27 June 2019

Linkage Disequilibrium in Genetic Association Studies Improves the Performance of Grammatical Evolution Neural Networks

scientific article published on 01 April 2007

Machine learning for detecting gene-gene interactions: a review

scientific article

Mechanistic indicators of childhood asthma (MICA) study: piloting an integrative design for evaluating environmental health.

scientific article

Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies

scientific article published on 22 June 2013

Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates

scientific article

Multidimensional in vivo hazard assessment using zebrafish

scientific article published on 17 October 2013

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

scientific article published on 01 April 2019

Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam

scientific article published on 14 November 2018

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

scientific article

Population genetic diversity in zebrafish lines

scientific article

Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 16 August 2019

Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses

scientific article published on 10 July 2014

Predictive model of rat reproductive toxicity from ToxCast high throughput screening

scientific article

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data

scientific article

Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data

scientific article

Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays

scientific article published on 16 May 2013

Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database

scientific article published on 20 October 2008

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

scientific article

Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells

scientific article published on 10 June 2013

Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles

scientific article published on 12 November 2019

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines

scientific article published on 15 October 2019

Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish

scientific article published on 02 April 2019

Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

scientific article published on 02 March 2022

Test driving ToxCast: endocrine profiling for 1858 chemicals included in phase II.

scientific article

The effect of bioactive glass ceramics on the expression of bone-related genes and proteins in vitro

scientific article

The multi-dimensional embryonic zebrafish platform predicts flame retardant bioactivity

scientific article published on 19 August 2020

ToxCast: Predicting Toxicity Potential Through High-Throughput Bioactivity Profiling

article

ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence

scientific article

ToxPi Graphical User Interface 2.0: Dynamic exploration, visualization, and sharing of integrated data models

scientific article published on 5 March 2018

Toxicity testing in the 21st century beyond environmental chemicals

scientific article published in January 2015

Transgenerational inheritance of neurobehavioral and physiological deficits from developmental exposure to benzo[a]pyrene in zebrafish

scientific article published on 02 June 2017

Update on EPA's ToxCast program: providing high throughput decision support tools for chemical risk management.

scientific article published on 15 May 2012

Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

scientific article

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

scientific article

Using in vitro high throughput screening assays to identify potential endocrine-disrupting chemicals.

scientific article published on 28 September 2012

Using nuclear receptor activity to stratify hepatocarcinogens

scientific article

Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals

scientific article published on February 2010

Zebrafish developmental screening of the ToxCast™ Phase I chemical library.

scientific article

List of works by David M. Reif

A New Statistical Approach to Characterize Chemical-Elicited Behavioral Effects in High-Throughput Studies Using Zebrafish

A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

A comparison of analytical methods for genetic association studies

A computational model predicting disruption of blood vessel development

A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades.

Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database

Advancing toxicology research using in vivo high throughput toxicology with small fish models

Aggregate entropy scoring for quantifying activity across endpoints with irregular correlation structure.

Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System

An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines

Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity

Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Associations between access to healthcare, environmental quality, and end-stage renal disease survival time: Proportional-hazards models of over 1,000,000 people over 14 years

Bayesian matrix completion for hypothesis testing

Characterizing the effects of missing data and evaluating imputation methods for chemical prioritization applications using ToxPi.

Children's Environmental Health: A Systems Approach for Anticipating Impacts from Chemicals

Combinatorial pharmacogenetics

Comparative microarray analysis and pulmonary changes in Brown Norway rats exposed to ovalbumin and concentrated air particulates

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging

Comparison of toxicity values across zebrafish early life stages and mammalian studies: Implications for chemical testing

Confirmation of high-throughput screening data and novel mechanistic insights into VDR-xenobiotic interactions by orthogonal assays.

Cytokine expression patterns associated with systemic adverse events following smallpox immunization

Data-driven asthma endotypes defined from blood biomarker and gene expression data

Decision tree-based method for integrating gene expression, demographic, and clinical data to determine disease endotypes.

Determination of chemical-disease risk values to prioritize connections between environmental factors, genetic variants, and human diseases

Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate

Editor's Highlight: Analysis of the Effects of Cell Stress and Cytotoxicity on In Vitro Assay Activity Across a Diverse Chemical and Assay Space.

Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes.

Elucidating Gene-by-Environment Interactions Associated with Differential Susceptibility to Chemical Exposure

Endocrine profiling and prioritization of environmental chemicals using ToxCast data

Environmental impact on vascular development predicted by high-throughput screening

Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay

Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population

Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership

Exploratory Visual Analysis of statistical results from microarray experiments comparing high and low grade glioma

Exploratory visual analysis of pharmacogenomic results.

Feature Selection using a Random Forests Classifier for the Integrated Analysis of Multiple Data Types

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka, Oryzias latipes.

Genetic basis for adverse events after smallpox vaccination

HGBEnviroScreen: Enabling Community Action through Data Integration in the Houston-Galveston-Brazoria Region

Hierarchical dose-response modeling for high-throughput toxicity screening of environmental chemicals

High-throughput characterization of chemical-associated embryonic behavioral changes predicts teratogenic outcomes

High-throughput models for exposure-based chemical prioritization in the ExpoCast project

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study.

Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

Inappropriate Citation of Vaccine Article

Incorporating Biological, Chemical, and Toxicological Knowledge Into Predictive Models of Toxicity

Incorporating ToxCast and Tox21 datasets to rank biological activity of chemicals at Superfund sites in North Carolina.

Incorporating exposure information into the toxicological prioritization index decision support framework

Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening.

Integrated analysis of genetic, genomic and proteomic data

Integrating Morphological and Behavioral Phenotypes in Developing Zebrafish

Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways

Linkage Disequilibrium in Genetic Association Studies Improves the Performance of Grammatical Evolution Neural Networks

Machine learning for detecting gene-gene interactions: a review

Mechanistic indicators of childhood asthma (MICA) study: piloting an integrative design for evaluating environmental health.

Meta-analysis of toxicity and teratogenicity of 133 chemicals from zebrafish developmental toxicity studies

Molecular cloning, functional characterization, and evolutionary analysis of vitamin D receptors isolated from basal vertebrates

Multidimensional in vivo hazard assessment using zebrafish

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

Neonatal mice exposed to a high-fat diet in utero influence the behaviour of their nursing dam

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

Population genetic diversity in zebrafish lines

Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes

Predictive endocrine testing in the 21st century using in vitro assays of estrogen receptor signaling responses

Predictive model of rat reproductive toxicity from ToxCast high throughput screening

Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data

Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data

Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays

Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database

Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway

Real-time growth kinetics measuring hormone mimicry for ToxCast chemicals in T-47D human ductal carcinoma cells

Sex-specific effects of perinatal FireMaster® 550 (FM 550) exposure on socioemotional behavior in prairie voles

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines

Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish

Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish