List of works by Marco Mor

2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists

scientific article published on August 2001

2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.

scientific article published on September 1998

3-Aminoazetidin-2-one derivatives as N-acylethanolamine acid amidase (NAAA) inhibitors suitable for systemic administration

scientific article published on 14 May 2014

5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line

scientific article

5-benzylidene-hydantoins as new EGFR inhibitors with antiproliferative activity.

scientific article published on 19 May 2006

A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation.

scientific article

A catalytic mechanism for cysteine N-terminal nucleophile hydrolases, as revealed by free energy simulations

scientific article

A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivo

scientific article

Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

scientific article

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

scientific article published on 22 March 2013

An endocannabinoid mechanism for stress-induced analgesia.

scientific article

Analysis of illicit dietary supplements sold in the Italian market: identification of a sildenafil thioderivative as adulterant using UPLC-TOF/MS and GC/MS

scientific article published on 14 March 2014

Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models

scientific article published on June 2005

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.

scientific article published on 19 September 2010

Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats

scientific article

Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

scientific article

Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress

scientific article

Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models

scientific article

Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam

scientific article

Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors

scientific article published on 01 November 2005

Application of a SCC-DFTB QM/MM approach to the investigation of the catalytic mechanism of fatty acid amide hydrolase

scientific article published on 02 March 2011

Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs

scientific article

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

scientific article published on 02 December 2019

Biochemical characterization of EphA2 antagonists with improved physico-chemical properties by cell-based assays and surface plasmon resonance analysis

scientific article published on 10 October 2015

Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors

scientific article published on 28 June 2011

Brain pharmacokinetics of non-imidazole biphenyl H3 receptor antagonists: a liquid chromatography/electrospray-mass spectrometry and ex vivo binding study in rats.

scientific article published in July 2012

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety.

scientific article

Catalytic, asymmetric hypervinylogous Mukaiyama aldol reactions of extended furan-based silyl enolates

scientific article published on 11 August 2011

Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation.

scientific article published on 3 December 2004

Chiral NMR discrimination of the diastereoisomeric salts of the H3-antagonist 2-[3-(1H-imidazol-4-ylmethyl)piperidin-1-yl]-1H-benzimidazole.

scientific article published in June 2009

Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria

scientific article published on 04 September 2020

Cholinergic agents structurally related to furtrethonium. 2. Synthesis and antimuscarinic activity of a series of N-[5-[(1'-substituted-acetoxy) methyl]-2-furfuryl]dialkylamines

scientific article published on 01 December 1994

Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.

scientific article published on 4 April 2016

Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction.

scientific article published on 7 October 2014

Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists.

scientific article published on 17 September 2015

Complex product composition generates risks for generic substitution also with dosage forms for intravenous administration.

scientific article published on 27 April 2013

Conformational Propensity and Biological Studies of Proline Mutated LR Peptides Inhibiting Human Thymidylate Synthase and Ovarian Cancer Cell Growth

scientific article published on 13 August 2018

Conformational effects in enzyme catalysis: reaction via a high energy conformation in fatty acid amide hydrolase

scientific article published on 10 November 2006

Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study

scientific article published in June 1997

Correction to Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo

scientific article published on 28 September 2020

Correction to Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8.

scientific article published on 2 February 2017

Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors

scientific article published on 01 December 2007

Covalent inhibitors of fatty acid amide hydrolase: a rationale for the activity of piperidine and piperazine aryl ureas.

scientific article published on 8 September 2011

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

scientific article

Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands.

scientific article

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

scientific article

Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazole H3 antagonist ROS203 in rat plasma

scientific article published on 18 September 2007

Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.

scientific article published on 20 December 2011

Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).

scientific article published on 24 April 2013

Discovery of potent and reversible monoacylglycerol lipase inhibitors.

scientific article

Divergent synthesis of novel 9-deazaxanthine derivatives via late-stage cross-coupling reactions.

scientific article

Dual mechanisms of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines

scientific article published on February 2008

Epidermal growth factor receptor irreversible inhibitors: chemical exploration of the cysteine-trap portion.

scientific article published on October 2011

Epidermal growth factor receptor tyrosine kinase inhibitors: current status and future perspectives in the development of novel irreversible inhibitors for the treatment of mutant non-small cell lung cancer

scientific article published on January 2013

Expanding the Arsenal of FGFR Inhibitors: A Novel Chloroacetamide Derivative as a New Irreversible Agent With Anti-proliferative Activity Against FGFR1-Amplified Lung Cancer Cell Lines

Exploiting Free-Energy Minima to Design Novel EphA2 Protein-Protein Antagonists: From Simulation to Experiment and Return.

scientific article published on 3 May 2016

FGF trapping inhibits multiple myeloma growth through c-Myc degradation-induced mitochondrial oxidative stress

scientific article published on 24 February 2020

Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents

scientific article published on 16 June 2016

Fatty acid amide hydrolase inhibitors: a patent review (2009-2014)

scientific article

Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL.

scientific article published on 8 August 2016

Functional characterization of gefitinib uptake in non-small cell lung cancer cell lines.

scientific article published on 2 April 2010

H3-receptor antagonists: synthesis and structure-activity relationships of para- and meta-substituted 4(5)-phenyl-2-[[2-[4(5)-imidazolyl]ethyl]thio]imidazoles

scientific article published in August 1997

Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines

scientific article published on 3 September 2015

Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit

scientific article published on 04 September 2018

Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754).

scientific article

Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling

scientific article

Imidazole H3-antagonists: relationship between structure and ex vivo binding to rat brain H3-receptors

scientific article

Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities

scientific article published in March 2004

Insights in the mechanism of action and inhibition of N-acylethanolamine acid amidase by means of computational methods

scientific article

Insights into the mechanism and inhibition of fatty acid amide hydrolase from quantum mechanics/molecular mechanics (QM/MM) modelling.

scientific article published on April 2009

Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 7. Synthesis and Pharmacological Evaluation of 4-Quinolone-3-carboxamides and 4-Hydroxy-2-quinolone-3-carboxamides as High Affinity Cannabinoid Receptor 2 (CB2R) Ligands with Improved Aqueou

scientific article published on 12 January 2016

Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.

scientific article published on 17 February 2012

Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase.

scientific article published on 13 January 2016

L718Q Mutation as New Mechanism of Acquired Resistance to AZD9291 in EGFR-Mutated NSCLC.

scientific article published on 30 May 2016

L718Q mutant EGFR escapes covalent inhibition by stabilizing a non-reactive conformation of the lung cancer drug osimertinib.

scientific article

Liquid chromatography-mass spectrometric method for determination of the non-imidazole H3-receptor antagonist UPR1056 in rat plasma

scientific article published on 06 June 2011

Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy

scientific journal article

Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.

scientific article published on 11 August 2013

MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides.

scientific article

Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders

scientific article

Melatonin receptor agonists: new options for insomnia and depression treatment

scientific article published on December 2011

Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study

scientific article published in September 1998

Metabolism of the EGFR tyrosin kinase inhibitor gefitinib by cytochrome P450 1A1 enzyme in EGFR-wild type non small cell lung cancer cell lines.

scientific article

Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8.

scientific article published on 12 January 2017

Modulation of anxiety through blockade of anandamide hydrolysis

scientific article (publication date: 2003)

Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer.

scientific article published on January 2013

Monoglyceride lipase: Structure and inhibitors.

scientific article published on 24 July 2015

N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

scientific article published on 10 May 2012

N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands

scientific article published in October 2009

N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands

scientific article

N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition

scientific article published on 26 March 2020

New classes of potent heparanase inhibitors from ligand-based virtual screening

scientific article published on 01 December 2020

Nonempirical energetic analysis of reactivity and covalent inhibition of fatty acid amide hydrolase

scientific article

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity

scientific article published on 30 July 2018

Novel Symmetrical Benzazolyl Derivatives Endowed with Potent anti-Heparanase Activity

scientific article published on 29 November 2018

Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons

scientific article published on May 2015

Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy

scientific article published on 08 May 2015

Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties.

scientific article

Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity?

scientific article published on 27 April 2016

Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

scientific article published on January 2006

Pharmacological tools in endocannabinoid neurobiology

scientific article published on 01 January 2009

Physical Nature of Fatty Acid Amide Hydrolase Interactions with Its Inhibitors: Testing a Simple Nonempirical Scoring Model

scientific article published on 10 December 2014

Predicting the reactivity of nitrile-carrying compounds with cysteine: a combined computational and experimental study

scientific article

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand

scientific journal article

Pushing the boundaries of vinylogous reactivity: catalytic enantioselective mukaiyama aldol reactions of highly unsaturated 2-silyloxyindoles

scientific article published on 03 March 2015

QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation.

scientific article published on 11 July 2005

Qualitative structure-metabolism relationships in the hydrolysis of carbamates.

scientific article

Quantum mechanics/molecular mechanics modeling of covalent addition between EGFR-cysteine 797 and N-(4-anilinoquinazolin-6-yl) acrylamide.

scientific article

Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors

scientific article published on 7 March 2013

Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

scientific article published on 20 January 2006

Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists.

scientific article published on August 2010

ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors

scientific article

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.

scientific article

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

scientific article

Statistical analysis on a series of glycine antagonists

scientific article published on 01 March 2000

Structural Fluctuations in Enzyme-Catalyzed Reactions: Determinants of Reactivity in Fatty Acid Amide Hydrolase from Multivariate Statistical Analysis of Quantum Mechanics/Molecular Mechanics Paths

scientific article published on 03 August 2010

Structure-affinity relationships of indole-based melatonin analogs.

scientific article

Structure-based virtual screening of MT2 melatonin receptor: influence of template choice and structural refinement.

scientific article

Structure–property relationships on histamine H3-antagonists: binding of phenyl-substituted alkylthioimidazole derivatives to rat plasma proteins

scientific article published in April 2000

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

scientific article published on 01 January 2006

Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

scientific article published on 01 January 2000

Synthesis and biological evaluation of new non-imidazole H3-receptor antagonists of the 2-aminobenzimidazole series

scientific article published on 2 November 2005

Synthesis and characterization of new bivalent agents as melatonin- and histamine H3-ligands

scientific article published on 12 September 2014

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

scientific article published on 29 May 2008

Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor.

scientific article

Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors

scientific article

Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.

scientific article

Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity

scientific article

Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.

scientific article

Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists

scientific article published in September 2003

Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor.

scientific article published on 21 October 2013

Synthesis and three-dimensional quantitative structure-activity relationship analysis of H3 receptor antagonists containing a neutral heterocyclic polar group

scientific article published in January 2003

Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.

scientific article published on 16 January 2013

Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors.

scientific article

Synthesis, antioxidant activity and structure-activity relationships for a new series of 2-(N-acylaminoethyl)indoles with melatonin-like cytoprotective activity.

scientific article published in April 2006

Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists.

scientific article published in February 2004

Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists

scientific article published on December 2007

Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.

scientific article published on April 2001

Synthesis, pharmacological evaluation, and structure-activity relationships of benzopyran derivatives with potent SERM activity

scientific article

Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands.

scientific article published on 29 March 2018

The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

scientific article published on 11 March 2015

The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity

scientific article published on 01 April 2009

The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice

scientific article

The fatty-acid amide hydrolase inhibitor URB597 does not affect triacylglycerol hydrolysis in rat tissues

scientific article

Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.

scientific article published in April 2003

Toward the definition of stereochemical requirements for MT2-selective antagonists and partial agonists by studying 4-phenyl-2-propionamidotetralin derivatives

scientific article published on 18 November 2011

Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties

scientific article published on 13 April 2014

Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.

scientific article

URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.

scientific article

Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling

scientific article published on 14 January 2011

UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations.

scientific article

Validation of a histamine H3 receptor model through structure-activity relationships for classical H3 antagonists

scientific article published in October 2005

pH-partition profiles of 4-(3-oxo-1,2-benzisothiazolin-2-yl)phenyl and phenoxyalkanoic acids

scientific article published in September 2003

Δ(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system

scientific article published on 29 August 2015

β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine

scientific article

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