List of works - Silvia Rivara

2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists

scientific article published on August 2001

2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.

scientific article published on September 1998

Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

scientific article

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

scientific article published on 22 March 2013

Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models

scientific article published on June 2005

Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats

scientific article

Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam

scientific article

Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors

scientific article published on 01 November 2005

Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs

scientific article

Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR

scientific article published on 13 November 2018

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

scientific article published on 02 December 2019

Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: Steric effects of N-alkyl chain on rat plasma and liver stability ⬇️

scientific article published on July 21, 2011

Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors

scientific article published on 28 June 2011

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety.

scientific article

Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria

scientific article published on 04 September 2020

Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction.

scientific article published on 7 October 2014

Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study

scientific article published in June 1997

Correction to Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8.

scientific article published on 2 February 2017

Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors

scientific article published on 01 December 2007

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

scientific article

Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands.

scientific article

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

scientific article

Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.

scientific article published on 20 December 2011

Epidermal growth factor receptor irreversible inhibitors: chemical exploration of the cysteine-trap portion.

scientific article published on October 2011

H3-receptor antagonists: synthesis and structure-activity relationships of para- and meta-substituted 4(5)-phenyl-2-[[2-[4(5)-imidazolyl]ethyl]thio]imidazoles

scientific article published in August 1997

Homology Models of Melatonin Receptors: Challenges and Recent Advances ⬇️

scientific article published on April 12, 2013

Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit

scientific article published on 04 September 2018

Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754).

scientific article

Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling

scientific article

Insights in the mechanism of action and inhibition of N-acylethanolamine acid amidase by means of computational methods

scientific article

Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.

scientific article published on 17 February 2012

Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.

scientific article published on 11 August 2013

MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

scientific article

MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides.

scientific article

Melatonin Receptor Agonists: New Options for Insomnia and Depression Treatment ⬇️

scientific article published on December 1, 2011

Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders

scientific article

Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study

scientific article published in September 1998

Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8.

scientific article published on 12 January 2017

Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor.

scientific article published on 22 December 2016

N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

scientific article published on 10 May 2012

N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands

scientific article published in October 2009

N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands

scientific article

New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform

scientific article published on 30 July 2019

New classes of potent heparanase inhibitors from ligand-based virtual screening

scientific article published on 01 December 2020

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity

scientific article published on 30 July 2018

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

scientific article

Novel Symmetrical Benzazolyl Derivatives Endowed with Potent anti-Heparanase Activity

scientific article published on 29 November 2018

Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy

scientific article published on 08 May 2015

Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties.

scientific article

Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity?

scientific article published on 27 April 2016

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand

scientific journal article

Quantum mechanics/molecular mechanics modeling of covalent addition between EGFR-cysteine 797 and N-(4-anilinoquinazolin-6-yl) acrylamide.

scientific article

Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors

scientific article published on 7 March 2013

Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

scientific article published on 20 January 2006

Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists.

scientific article published on August 2010

ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors

scientific article

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.

scientific article

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

scientific article

Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates

scientific article published on 20 May 2017

Structural Fluctuations in Enzyme-Catalyzed Reactions: Determinants of Reactivity in Fatty Acid Amide Hydrolase from Multivariate Statistical Analysis of Quantum Mechanics/Molecular Mechanics Paths

scientific article published on 03 August 2010

Structure-based virtual screening of MT2 melatonin receptor: influence of template choice and structural refinement.

scientific article

Structure–property relationships on histamine H3-antagonists: binding of phenyl-substituted alkylthioimidazole derivatives to rat plasma proteins

scientific article published in April 2000

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

scientific article published on 01 January 2006

Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

scientific article published on 01 January 2000

Synthesis and characterization of new bivalent agents as melatonin- and histamine H3-ligands

scientific article published on 12 September 2014

Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD).

scientific article published on 16 November 2017

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

scientific article published on 29 May 2008

Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.

scientific article

Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists

scientific article published in September 2003

Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor.

scientific article published on 21 October 2013

Synthesis and three-dimensional quantitative structure-activity relationship analysis of H3 receptor antagonists containing a neutral heterocyclic polar group

scientific article published in January 2003

Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.

scientific article published on 16 January 2013

Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists

scientific article published on December 2007

Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.

scientific article published on April 2001

Synthesis, pharmacological evaluation, and structure-activity relationships of benzopyran derivatives with potent SERM activity

scientific article

Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate

scientific article

Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands

scientific article published on 29 March 2018

The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity

scientific article published on 01 April 2009

Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 - 2014).

scientific article

Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.

scientific article published in April 2003

Toward the definition of stereochemical requirements for MT2-selective antagonists and partial agonists by studying 4-phenyl-2-propionamidotetralin derivatives

scientific article published on 18 November 2011

Towards the development of 5-HT7 ligands combining serotonin-like and arylpiperazine moieties

scientific article published on 13 April 2014

Tricyclic alkylamides as melatonin receptor ligands with antagonist or inverse agonist activity.

scientific article

URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices.

scientific article

Understanding the role of carbamate reactivity in fatty acid amide hydrolase inhibition by QM/MM mechanistic modelling

scientific article published on 14 January 2011

UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations.

scientific article

List of works by Silvia Rivara

2-N-acylaminoalkylindoles: design and quantitative structure-activity relationship studies leading to MT2-selective melatonin antagonists

2-[N-Acylamino(C1-C3)alkyl]indoles as MT1 melatonin receptor partial agonists, antagonists, and putative inverse agonists.

Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models

Antidepressant-like activity and cardioprotective effects of fatty acid amide hydrolase inhibitor URB694 in socially stressed Wistar Kyoto rats

Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam

Application of 3D-QSAR in the Rational Design of Receptor Ligands and Enzyme Inhibitors

Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs

Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: Steric effects of N-alkyl chain on rat plasma and liver stability ⬇️

Bivalent ligand approach on N-{2-[(3-methoxyphenyl)methylamino]ethyl}acetamide: synthesis, binding affinity and intrinsic activity for MT(1) and MT(2) melatonin receptors

Cardioprotective effects of fatty acid amide hydrolase inhibitor URB694, in a rodent model of trait anxiety.

Chiral Recognition of Flexible Melatonin Receptor Ligands Induced by Conformational Equilibria

Combining ligand- and structure-based approaches for the discovery of new inhibitors of the EPHA2-ephrin-A1 interaction.

Conformationally restrained melatonin analogues: synthesis, binding affinity for the melatonin receptor, evaluation of the biological activity, and molecular modeling study

Correction to Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8.

Correlation between energetics of collisionally activated decompositions, interaction energy and biological potency of carbamate FAAH inhibitors

Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies

Design and synthesis of N-(3,3-diphenylpropenyl)alkanamides as a novel class of high-affinity MT2-selective melatonin receptor ligands.

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.

Epidermal growth factor receptor irreversible inhibitors: chemical exploration of the cysteine-trap portion.

H3-receptor antagonists: synthesis and structure-activity relationships of para- and meta-substituted 4(5)-phenyl-2-[[2-[4(5)-imidazolyl]ethyl]thio]imidazoles

Homology Models of Melatonin Receptors: Challenges and Recent Advances ⬇️

Identification of Bivalent Ligands with Melatonin Receptor Agonist and Fatty Acid Amide Hydrolase (FAAH) Inhibitory Activity That Exhibit Ocular Hypotensive Effect in the Rabbit

Identification of a bioactive impurity in a commercial sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754).

Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling

Insights in the mechanism of action and inhibition of N-acylethanolamine acid amidase by means of computational methods

Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.

Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.

MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.

MT1-selective melatonin receptor ligands: synthesis, pharmacological evaluation, and molecular dynamics investigation of N-{[(3-O-substituted)anilino]alkyl}amides.

Melatonin Receptor Agonists: New Options for Insomnia and Depression Treatment ⬇️

Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders

Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study

Metadynamics Simulations Distinguish Short- and Long-Residence-Time Inhibitors of Cyclin-Dependent Kinase 8.

Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor.

N-(2-Oxo-3-oxetanyl)carbamic Acid Esters as N-Acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure–Activity and Structure–Property Relationships

N-(Anilinoethyl)amides: design and synthesis of metabolically stable, selective melatonin receptor ligands

N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands

New Antimicrobials Targeting Bacterial RNA Polymerase Holoenzyme Assembly Identified with an in Vivo BRET-Based Discovery Platform

New classes of potent heparanase inhibitors from ligand-based virtual screening

Novel Benzazole Derivatives Endowed with Potent Antiheparanase Activity

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

Novel Symmetrical Benzazolyl Derivatives Endowed with Potent anti-Heparanase Activity

Pharmacokinetic and pharmacodynamic evaluation of ramelteon : an insomnia therapy

Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties.

Pharmacological inhibition of FAAH activity in rodents: A promising pharmacological approach for psychological-cardiac comorbidity?

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand

Quantum mechanics/molecular mechanics modeling of covalent addition between EGFR-cysteine 797 and N-(4-anilinoquinazolin-6-yl) acrylamide.

Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors

Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

Recent advances in the development of melatonin MT(1) and MT(2) receptor agonists.

ST7612AA1, a thioacetate-ω(γ-lactam carboxamide) derivative selected from a novel generation of oral HDAC inhibitors

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

Social stress contagion in rats: Behavioural, autonomic and neuroendocrine correlates

Structural Fluctuations in Enzyme-Catalyzed Reactions: Determinants of Reactivity in Fatty Acid Amide Hydrolase from Multivariate Statistical Analysis of Quantum Mechanics/Molecular Mechanics Paths

Structure-based virtual screening of MT2 melatonin receptor: influence of template choice and structural refinement.

Structure–property relationships on histamine H3-antagonists: binding of phenyl-substituted alkylthioimidazole derivatives to rat plasma proteins

Synthesis and Structure-Activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring

Synthesis and biological assays of new H3-antagonists with imidazole and imidazoline polar groups

Synthesis and characterization of new bivalent agents as melatonin- and histamine H3-ligands

Synthesis and characterization of the first inhibitor of N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD).

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors.

Synthesis and structure-activity relationships of a series of pyrrole cannabinoid receptor agonists

Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor.

Synthesis and three-dimensional quantitative structure-activity relationship analysis of H3 receptor antagonists containing a neutral heterocyclic polar group

Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.

Synthesis, enantiomeric resolution, and structure-activity relationship study of a series of 10,11-dihydro-5H-dibenzo[a,d]cycloheptene MT2 receptor antagonists

Synthesis, pharmacological characterization and QSAR studies on 2-substituted indole melatonin receptor ligands.

Synthesis, pharmacological evaluation, and structure-activity relationships of benzopyran derivatives with potent SERM activity

Synthesis, structure and inhibitory activity of a stereoisomer of oseltamivir carboxylate

Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands

The collisional behavior of ESI-generated protonated molecules of some carbamate FAAH inhibitors isosteres and its relationships with biological activity

Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012 - 2014).