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List of works by Piero Pollesello

1H NMR spectroscopic studies of lipid extracts from human fatty liver

scientific article published on 01 May 1993

1H-NMR studies of lipid extracts of rat liver mitochondria

scientific article published on 01 September 1991

A cellular UDP-glucose deficiency causes overexpression of glucose/oxygen-regulated proteins independent of the endoplasmic reticulum stress elements.

scientific article published on 12 March 2004

A pragmatic approach to the use of inotropes for the management of acute and advanced heart failure: An expert panel consensus

scientific article published on 06 September 2019

A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart

scientific article published on 25 February 2008

Absence of mitochondrial activation during levosimendan inotropic action in perfused paced guinea pig hearts as demonstrated by modular control analysis.

scientific article published on 30 June 2010

Advanced heart failure: an appraisal of the potential of levosimendan in this end-stage scenario and some related ethical considerations

scientific article

Analysis of lipids in crude extracts by 13C nuclear magnetic resonance

scientific article published on 01 October 1993

Analysis of total lipid extracts from human liver by 13C and 1H nuclear magnetic resonance spectroscopy.

scientific article published on April 1996

Calcium sensitizers: What have we learned over the last 25 years?

scientific article

Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene.

scientific article

Changed Relation between Phosphorylation Potential and Left Ventricular Developed Pressure in Guinea Pig Hearts during Ischemia-Reperfusion a.

scientific article published in June 1994

Complete structure analysis of OR-1746, a complex product of cyclocondensation of arylhydrazomalononitriles containing clusters of protonated and unprotonated nitrogens, by pulsed-field-gradient heteronuclear NMR.

scientific article

Complex electrophysiological remodeling in postinfarction ischemic heart failure.

scientific article published on 12 March 2018

Conformations of the regulatory domain of cardiac troponin C examined by residual dipolar couplings

scientific article

Cost-benefits of incorporating levosimendan into cardiac surgery practice: German base case.

scientific article published on 26 December 2015

Discovery and structural characterization of a phospholamban-binding cyclic peptide and design of novel inhibitors of phospholamban

scientific article

Drug discovery and development for acute heart failure drugs: are expectations too high?

scientific article published on 04 January 2014

Economic evaluation of levosimendan versus dobutamine for the treatment of acute heart failure in Italy

scientific article published on 06 December 2012

Effect of baseline characteristics on mortality in the SURVIVE trial on the effect of levosimendan vs dobutamine in acute heart failure: Sub-analysis of the Finnish patients

scientific article

Effect of levosimendan and milrinone on regional myocardial ischemia/reperfusion-induced arrhythmias in dogs

scientific article published on 01 June 2006

Effect of levosimendan on balance between ATP production and consumption in isolated perfused guinea-pig heart before ischemia or after reperfusion

scientific article published in September 2004

Effects of Levosimendan on Inflammation and Oxidative Stress Pathways in a Lipopolysaccharide-Stimulated Human Endothelial Cell Model

scientific article published on 04 July 2019

Effects of levosimendan and milrinone on oxygen consumption in isolated guinea-pig heart

scientific article published in April 2004

Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats. ⬇️

scientific article published on 26 February 2007

Effects of levosimendan on the energy balance: preclinical and clinical evidence

scientific article published on April 2009

Efficacy of selective NCX inhibition by ORM-10103 during simulated ischemia/reperfusion

scientific article published on 27 June 2014

Energy metabolism, replicative ability, intracellular calcium concentration, and ionic channels of horse articular chondrocytes

scientific article published on 01 January 1994

Energy state of chondrocytes assessed by 31P-NMR studies of preosseous cartilage

scientific article published on 01 October 1991

Haemodynamic Balance in Acute and Advanced Heart Failure: An Expert Perspective on the Role of Levosimendan

scientific article published on 04 November 2019

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology

scientific article published on 01 December 2018

Improved survival with simendan after experimental myocardial infarction in rats

scientific article

Inhibition of lipid peroxidation in isolated rat liver mitochondria by the general anaesthetic propofol

scientific article published in July 1992

Inotropic effect of NCX inhibition depends on the relative activity of the reverse NCX assessed by a novel inhibitor ORM-10962 on canine ventricular myocytes

scientific article published on 21 October 2017

Integrating an artificial intelligence chatbot in scientific communication: Dos and don’ts

scientific article published in 2023

Interaction of levosimendan with cardiac troponin C in the presence of cardiac troponin I peptides

scientific article (publication date: September 2003)

Involvement of Rho kinase pathway in the mechanism of renal vasoconstriction and cardiac hypertrophy in rats with experimental heart failure

scientific article published on 16 December 2005

Lessons from Lisbon on AHF drug treatment: is it really true that all-old-failed-all-new-will-succeed?

scientific article published on 23 July 2013

Levosimendan Efficacy and Safety: 20 years of SIMDAX in Clinical Use

scientific article published on 22 June 2020

Levosimendan Efficacy and Safety: 20 years of SIMDAX in Clinical Use

scientific article published on 01 March 2020

Levosimendan Improves Oxidative Balance in Cardiogenic Shock/Low Cardiac Output Patients

scientific article published on 30 January 2020

Levosimendan alone and in combination with valsartan prevents stroke in Dahl salt-sensitive rats

scientific article published on 29 January 2015

Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper

scientific article

Levosimendan in Acute and Advanced Heart Failure: an Expert Perspective on Posology and Therapeutic Application

scientific article published on 01 December 2018

Levosimendan in acute and advanced heart failure: an appraisal of the clinical database and evaluation of its therapeutic applications.

scientific article

Levosimendan increases diastolic coronary flow in isolated guinea-pig heart by opening ATP-sensitive potassium channels

scientific article published in April 2001

Levosimendan inhibits peroxidation in hepatocytes by modulating apoptosis/autophagy interplay

scientific article published on 16 April 2015

Levosimendan is a mitochondrial K(ATP) channel opener

scientific article published in October 2001

Levosimendan meta-analyses: Is there a pattern in the effect on mortality?

scientific article

Levosimendan protection against kidney ischemia/reperfusion injuries in anesthetized pigs.

scientific article

Long-term effects of Na+ /Ca2+ exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction

scientific article published on 24 November 2019

Modification of plasma membrane of differentiating preosseous chondrocytes: evidence for a degradative process in the mechanism of matrix vesicle formation

scientific article published on 01 June 1990

Noninvasive in vivo quantitative assessment of fat content in human liver

scientific article published on 01 July 1997

Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue

scientific article published on 01 January 2019

ORM-10103, a novel specific inhibitor of the Na+/Ca2+ exchanger, decreases early and delayed afterdepolarizations in the canine heart

scientific article published on October 2013

ORM-3819 promotes cardiac contractility through Ca(2+) sensitization in combination with selective PDE III inhibition, a novel approach to inotropy.

scientific article

Organic solvent systems for 31P nuclear magnetic resonance analysis of lecithin phospholipids: applications to two-dimensional gradient-enhanced 1H-detected heteronuclear multiple quantum coherence experiments.

scientific article published on February 1997

Oxygen-derived free radical (ODFR) action on hyaluronan (HA), on two HA ester derivatives, and on the metabolism of articular chondrocytes

scientific article published on 01 May 1995

Pharmaco-economics of levosimendan in cardiology: a European perspective.

scientific article published on 15 July 2015

Positive inotropic effect of levosimendan is correlated to its stereoselective Ca2+-sensitizing effect but not to stereoselective phosphodiesterase inhibition

scientific article published in January 2006

Possible mechanism of inhibition of cartilage alkaline phosphatase by insulin

scientific article published on 01 October 1989

Potassium-specific effects of levosimendan on heart mitochondria

scientific article

Potential of the Cardiovascular Drug Levosimendan in the Management of Amyotrophic Lateral Sclerosis: An Overview of a Working Hypothesis

scientific article published on 01 November 2019

Preconditioning effects of levosimendan in a rabbit cardiac ischemia-reperfusion model

scientific article published on 01 October 2006

Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion

scientific article

Prolonged antispasmodic effect in isolated radial artery graft and pronounced platelet inhibition induced by the inodilator drug, levosimendan

scientific article published on 21 October 2011

Protective effects elicited by levosimendan against liver ischemia/reperfusion injury in anesthetized rats

scientific article published on 27 January 2014

Rehospitalization after intermittent levosimendan treatment in advanced heart failure patients: a meta-analysis of randomized trials

scientific article

Renal effects of levosimendan: a consensus report

scientific article published on December 2013

Repetitive use of levosimendan for treatment of chronic advanced heart failure: clinical evidence, practical considerations, and perspectives: an expert panel consensus.

scientific article published on 18 April 2014

Repetitive use of levosimendan in advanced heart failure: need for stronger evidence in a field in dire need of a useful therapy.

scientific article published on 23 May 2017

Selective Na(+) /Ca(2+) exchanger inhibition prevents Ca(2+) overload-induced triggered arrhythmias

scientific article

Sensitivity of chondrocytes of growing cartilage to reactive oxygen species

scientific article published in September 1998

Short-Term Therapies for Treatment of Acute and Advanced Heart Failure-Why so Few Drugs Available in Clinical Use, Why Even Fewer in the Pipeline?

scientific article published on 01 November 2019

Solution Structure and Main Chain Dynamics of the Regulatory Domain (Residues 1–91) of Human Cardiac Troponin C ⬇️

scientific article published on June 19, 1998

Stereoselective binding of levosimendan to cardiac troponin C causes Ca2+-sensitization

scientific article published in February 2004

Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure

scientific article published on 01 November 2002

Structural determination of the acidic exopolysaccharide produced by a Pseudomonas sp. strain 1.15

scientific article published on 01 January 1999

Structure of the exopolysaccharide produced by Enterobacter amnigenus.

scientific article

The Effect of a Novel Highly Selective Inhibitor of the Sodium/Calcium Exchanger (NCX) on Cardiac Arrhythmias in In Vitro and In Vivo Experiments

scientific article

The Novel Inodilator ORM-3819 Relaxes Isolated Porcine Coronary Arteries: Role of Voltage-Gated Potassium Channel Activation

scientific article published on 01 September 2019

The autonomic nervous system as a therapeutic target in heart failure: a scientific position statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology

scientific article

The cardioprotective effects of levosimendan: preclinical and clinical evidence

scientific article published on September 2007

The clinical effects of levosimendan are not attenuated by sulfonylureas

scientific article published on 25 September 2012

The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.

scientific article

The effect of levosimendan during long-term amiodarone treatment in dogs

scientific article published on 01 July 2006

The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig

scientific article (publication date: 13 February 2004)

The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles

scientific article published on 22 May 2006

The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling

scientific article published on 13 February 2006

The role of levosimendan in acute heart failure complicating acute coronary syndrome: A review and expert consensus opinion

scientific article

Towards better definition, quantification and treatment of fibrosis in heart failure. A scientific roadmap by the Committee of Translational Research of the Heart Failure Association (HFA) of the European Society of Cardiology

scientific article published on 04 February 2019

Two inotropes with different mechanisms of action: contractile, PDE-inhibitory and direct myofibrillar effects of levosimendan and enoximone

scientific article published in September 2005

Use of Levosimendan in Cardiac Surgery: An Update After the LEVO-CTS, CHEETAH, and LICORN Trials in the Light of Clinical Practice.

scientific article published on 30 October 2017

Use of Levosimendan in Intensive Care Unit Settings: An Opinion Paper

article

Use of levosimendan in acute heart failure

scientific article published on 11 December 2018

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