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List of works by Ken A. Brameld

3-heterocyclyl quinolone inhibitors of the HCV NS5B polymerase

scientific article published on 9 November 2011

Characterization of RO5126946, a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator

scientific article

De novo fragment design: a medicinal chemistry approach to fragment-based lead generation

scientific article

Discovery of N -[4-[6- tert -Butyl-5-methoxy-8-(6-methoxy-2-oxo-1 H -pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a Potent Inhibitor of the Hepatitis C Virus NS5B Polymerase

scientific article

Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.

scientific article

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors.

scientific article published on 30 June 2017

Preclinical Efficacy and Anti-Inflammatory Mechanisms of Action of the Bruton Tyrosine Kinase Inhibitor Rilzabrutinib for Immune-Mediated Disease

scientific article published on 05 March 2021

Prolonged and tunable residence time using reversible covalent kinase inhibitors

scientific article published on 25 May 2015

Quinolones as HCV NS5B polymerase inhibitors

scientific article

Small molecule conformational preferences derived from crystal structure data. A medicinal chemistry focused analysis

scientific article

Substrate assistance in the mechanism of family 18 chitinases: theoretical studies of potential intermediates and inhibitors.

scientific article

Targeting interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) using a novel covalent inhibitor PRN694.

scientific article

The role of enzyme distortion in the single displacement mechanism of family 19 chitinases ⬇️

scientific article published on April 14, 1998

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