List of works by Alan J Williams

A Systemized Approach to Investigate Ca(2+) Synchronization in Clusters of Human Induced Pluripotent Stem-Cell Derived Cardiomyocytes

scientific article

A model for ionic conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum ⬇️

scientific article published on September 1, 1992

A model of the putative pore region of the cardiac ryanodine receptor channel

scientific article

A novel and rapid approach to isolating functional ryanodine receptors

scientific article published in June 2002

A possible molecular mechanism for 'stunning' of the myocardium.

scientific article published on December 1991

A single isotope method for the measurement of the volume of the mitochondrial inner compartment

scientific article published on 01 September 1980

ATP-induced stimulation of calcium binding to cardiac sarcolemma ⬇️

scientific article published on March 30, 1979

Activation of the sheep cardiac Ca2+ release channel by simple heteroaromatics.

scientific article published in April 2004

Activation of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by analogues of sulmazole.

scientific article published in April 1994

Adenosine discriminates between the caffeine and adenine nucleotide sites on the sheep cardiac sarcoplasmic reticulum calcium-release channel

scientific article published on 01 January 1994

An anionic ryanoid, 10-O-succinoylryanodol, provides insights into the mechanisms governing the interaction of ryanoids and the subsequent altered function of ryanodine-receptor channels

scientific article

An assay for inorganic orthophosphate in the presence of alkaloids and related drugs

scientific article published on 01 April 1977

Asymmetric block of a monovalent cation-selective channel of rabbit cardiac sarcoplasmic reticulum by succinyl choline

scientific article published on 01 January 1985

Block of the ryanodine receptor channel by neomycin is relieved at high holding potentials

scientific article

Block of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by tetra-alkyl ammonium cations

scientific article published on 01 April 1992

Calcium-proton exchange in cardiac and liver mitochondria ⬇️

scientific article published on January 15, 1979

Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain.

scientific article published on 08 September 2016

Cardiovascular receptors and calcium

scientific article published on 01 June 1980

Cation conduction in the calcium release channel of the cardiac sarcoplasmic reticulum under physiological and pathophysiological conditions.

scientific article published in October 1993

Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor.

scientific article published on February 2009

Characterization of a Ca(2+)-dependent anion channel from sheep tracheal epithelium incorporated into planar bilayers.

scientific article

Characterization of the ryanodine receptor-Ca2+ release channel from the thoracic tissues of the lepidopteran insect Heliothis virescens

scientific article

Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel.

scientific article

Chicken skeletal muscle ryanodine receptor isoforms: ion channel properties

scientific article

Comparison of the protein constituents of sarcoplasmic reticulum isolated from rat skeletal and cardiac muscle.

scientific article

Contamination of a cardiac sarcolemmal preparation with endothelial plasma membrane.

scientific article published on March 1986

Cyclic ADP-ribose and related compounds activate sheep skeletal sarcoplasmic reticulum Ca2+ release channel

scientific article published on 01 May 1995

Cyclic ADP-ribose competes with ATP for the adenine nucleotide binding site on the cardiac ryanodine receptor Ca(2+)-release channel

scientific article published on 01 September 1994

Dantrolene rescues aberrant N-terminus intersubunit interactions in mutant pro-arrhythmic cardiac ryanodine receptors.

scientific article published on 19 November 2014

Digoxin activates sarcoplasmic reticulum Ca(2+)-release channels: a possible role in cardiac inotropy.

scientific article published in April 1993

Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.

scientific article

Divalent cation conduction in the ryanodine receptor channel of sheep cardiac muscle sarcoplasmic reticulum ⬇️

scientific article published on September 1, 1992

Do inactivation mechanisms rather than adaptation hold the key to understanding ryanodine receptor channel gating?

scientific article

Effect of R56865 on cardiac sarcoplasmic reticulum function and its role as an antagonist of digoxin at the sarcoplasmic reticulum calcium release channel.

scientific article

Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor.

scientific article published on 30 May 2016

Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channel

scientific article

Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2)

scientific article

Evidence for Ca(2+) activation and inactivation sites on the luminal side of the cardiac ryanodine receptor complex

scientific article published on 01 August 2000

Evidence for negative charge in the conduction pathway of the cardiac ryanodine receptor channel provided by the interaction of K+ channel N-type inactivation peptides

scientific article published in June 1998

Evidence for novel caffeine and Ca2+ binding sites on the lobster skeletal ryanodine receptor

scientific article published in February 1999

Excess noise in modified conductance states following the interaction of ryanoids with cardiac ryanodine receptor channels

scientific article published in April 2002

Functional characterisation of the ryanodine receptor purified from sheep cardiac muscle sarcoplasmic reticulum

scientific article published on 01 April 1991

Functional characterization of the cardiac ryanodine receptor pore-forming region.

scientific article

Gating of the native and purified cardiac SR Ca(2+)-release channel with monovalent cations as permeant species

scientific article

Glycolytic pathway intermediates activate cardiac ryanodine receptors

scientific article

How does ryanodine modify ion handling in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel?

scientific article

Hypoxia and calcium ⬇️

scientific article published on July 1, 1979

Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+-release channel (ryanodine receptor 2).

scientific article

Ion conduction and discrimination in the sarcoplasmic reticulum ryanodine receptor/calcium-release channel

scientific article

Ion conduction and selectivity in the ryanodine receptor channel

scientific article

Large tetraalkyl ammonium cations produce a reduced conductance state in the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel ⬇️

scientific article published on May 1, 1992

Light at the end of the Ca(2+)-release channel tunnel: structures and mechanisms involved in ion translocation in ryanodine receptor channels

scientific article

Markovian models of low and high activity levels of cardiac ryanodine receptors

scientific article

Massive Accumulation of Myofibroblasts in the Critical Isthmus Is Associated With Ventricular Tachycardia Inducibility in Post-Infarct Swine Heart.

scientific article

Measurement of ionic exchange in organelle suspensions with ion-selective electrodes [proceedings]

scientific article published on April 1, 1979

Measuring the length of the pore of the sheep cardiac sarcoplasmic reticulum calcium-release channel using related trimethylammonium ions as molecular calipers

scientific article

Mechanisms of caffeine activation of single calcium-release channels of sheep cardiac sarcoplasmic reticulum

scientific article

Modification of gating of an airway epithelial chloride channel by 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB)

scientific article published on 01 June 1992

Modification of the conductance and gating properties of ryanodine receptors by suramin.

scientific article

Modification of the gating of the cardiac sarcoplasmic reticulum Ca(2+)-release channel by H2O2 and dithiothreitol.

scientific article

Modulation of single Ca2+-dependent K+-channel activity by protein phosphorylation

scientific article published on 01 June 1985

Molecular cloning, characterisation and mRNA expression of the ryanodine receptor from the peach-potato aphid, Myzus persicae.

scientific article

Monovalent cation conductance in the ryanodine receptor-channel of sheep cardiac muscle sarcoplasmic reticulum

scientific article published on 01 August 1991

Myocardial calcium signalling and arrhythmia pathogenesis.

scientific article published in October 2004

Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum.

scientific article published on 25 June 2009

N-terminus oligomerization regulates the function of cardiac ryanodine receptors

scientific article published on 13 August 2013

Ouabain-induced contractures in mammalian heart muscle [proceedings]

scientific article published on 01 February 1978

Patterns of interaction between anthraquinone drugs and the calcium-release channel from cardiac sarcoplasmic reticulum

scientific article published on 01 August 1990

Pharmacological regulators of intracellular calcium release channels.

scientific article published on January 2007

Phosphodiesterase inhibitors and the cardiac sarcoplasmic reticulum calcium release channel: differential effects of milrinone and enoximone.

scientific article

Probing luminal negative charge in the type 3 ryanodine receptor.

scientific article published on 5 October 2005

Protective effect of pretreatment with verapamil, nifedipine and propranolol on mitochondrial function in the ischemic and reperfused myocardium

scientific article published on 01 August 1980

Quantification of the effects of a ryanodine receptor channel mutation on interaction with a ryanoid

scientific article published on 01 May 2007

Questioning flecainide's mechanism of action in the treatment of catecholaminergic polymorphic ventricular tachycardia

scientific article published on November 2016

Reactive oxygen species modify the structure and function of the cardiac sarcoplasmic reticulum calcium-release channel.

scientific article

Reconstitution of cardiac sarcoplasmic reticulum calcium channels

scientific article published on 01 January 1989

Regulation of cardiac mitochondrial potassium-ion movements

scientific article published on 01 December 1980

Regulation of current flow through ryanodine receptors by luminal Ca2+.

scientific article published on October 1997

Regulation of the gating of the sheep cardiac sarcoplasmic reticulum Ca(2+)-release channel by luminal Ca2+.

scientific article published in February 1994

Relaxation in heart muscle: some morphological and biochemical considerations

scientific article published on June 1, 1978

Removal of clustered positive charge from dihydropyridine receptor II-III loop peptide augments activation of ryanodine receptors

scientific article published on February 2004

Residue Gln4863 within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction

scientific article published on 13 October 2003

Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate.

scientific article

Ryanodine receptor interaction with the SNARE-associated protein snapin

scientific journal article

Ryanodine receptor mutations in arrhythmia: The continuing mystery of channel dysfunction.

scientific article published on 02 February 2010

Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.

scientific article

Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains.

scientific article

Ryanodine-induced structural alterations in the RyR channel suggested by neomycin block.

scientific article

Sarcolemmal calcium transport and drug action

scientific article published on 01 January 1980

Separation of isolated cardiac sarcolemma into inside-out and right-side-out vesicles by affinity chromatography [proceedings]

scientific article published on 01 October 1979

Sheep cardiac sarcoplasmic reticulum calcium-release channels: modification of conductance and gating by temperature

scientific article published on 01 March 1991

Single channel recordings from human cardiac sarcoplasmic reticulum

scientific article published on 01 November 1989

Solubilisation and reconstitution of the rabbit skeletal muscle sarcoplasmic reticulum K+ channel into liposomes suitable for patch clamp studies

scientific article published on 01 September 1986

Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides

scientific article (publication date: October 2015)

Structural components of ryanodine responsible for modulation of sarcoplasmic reticulum calcium channel function

scientific article published on 01 March 1997

Structural insights into Ca(2+)-activated long-range allosteric channel gating of RyR1.

scientific article published on 30 August 2016

Sulmazole (AR-L 115BS) activates the sheep cardiac muscle sarcoplasmic reticulum calcium-release channel in the presence and absence of calcium

scientific article published on 01 May 1990

Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level.

scientific article published on January 2012

Temperature effects on the kinetics of calcium transport by cardiac mitochondria

scientific article published in September 1978

The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance

scientific article published on 14 June 2005

The calcium-release channel from cardiac sarcoplasmic reticulum: function in the failing and acutely ischaemic heart.

scientific article

The cardiac ryanodine receptor (calcium release channel): emerging role in heart failure and arrhythmia pathogenesis.

scientific article

The characterization of a monovalent cation-selective channel of mammalian cardiac muscle sarcoplasmic reticulum

scientific article published on 01 January 1984

The gating of the sheep skeletal sarcoplasmic reticulum Ca(2+)-release channel is regulated by luminal Ca2+.

scientific article

The interaction of an impermeant cation with the sheep cardiac RyR channel alters ryanoid association

scientific article published on 15 March 2006

The interaction of ryanoids with individual ryanodine receptor channels.

scientific article

The interactions of ATP, ADP, and inorganic phosphate with the sheep cardiac ryanodine receptor.

scientific article

The isolation and characterization of cardiac mitochondrial fractions from isoprenaline treated rats

scientific article published on 01 August 1981

The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2.

scientific article published on 3 February 2015

The ryanodine receptor pore: is there a consensus view?

scientific article published on 25 July 2010

The therapeutic potential of new insights into myocardial excitation-contraction coupling.

scientific article

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply.

scientific article published on 27 March 2013

Two orientations of isolated cardiac sarcolemmal vesicles separated by affinity chromatography

scientific article published on 01 April 1980

Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating

scientific article published on 05 October 2016

Using large organic cations to probe the nature of ryanodine modification in the sheep cardiac sarcoplasmic reticulum calcium release channel

scientific article

Voltage-sensitive equilibrium between two states within a ryanoid-modified conductance state of the ryanodine receptor channel

scientific article

Paulina is supported by:

About Paulina

Help