List of works - Fumitaka Kudo

A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics

scientific article published on 25 October 2011

A Unique Amino Transfer Mechanism for Constructing the β-Amino Fatty Acid Starter Unit in the Biosynthesis of the Macrolactam Antibiotic Cremimycin

scientific article published on 06 September 2013

A Unique Pathway for the 3-Aminobutyrate Starter Unit from l-Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine

scientific article published on 28 August 2012

A new family of glucose-1-phosphate/glucosamine-1-phosphate nucleotidylyltransferase in the biosynthetic pathways for antibiotics.

scientific article

A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin.

scientific article published on 6 June 2013

Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs

scientific article published on 12 October 2015

An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

scientific article published on 23 April 2019

Biochemical and Structural Analysis of a Dehydrogenase, KanD2, and an Aminotransferase, KanS2, That Are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis

scientific article published on 06 April 2020

Biochemical characterization and structural insight into aliphatic β-amino acid adenylation enzymes IdnL1 and CmiS6.

scientific article

Biosynthesis of 2-deoxystreptamine-containing antibiotics in Streptoalloteichus hindustanus JCM 3268: characterization of 2-deoxy-scyllo-inosose synthase. ⬇️

scientific article published in June 2006

Biosynthesis of natural products containing β-amino acids.

scientific article

C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-adenosyl-l-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration

scientific article published on 12 July 2018

C-Methylation of S-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium

scientific article published on 16 May 2020

Carbon-free production of 2-deoxy-scyllo-inosose (DOI) in cyanobacterium Synechococcus elongatus PCC 7942.

scientific article published on 3 January 2018

Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin

scientific article published on 01 January 2009

Characterization of Radical SAM Adenosylhopane Synthase, HpnH, which Catalyzes the 5'-Deoxyadenosyl Radical Addition to Diploptene in the Biosynthesis of C35 Bacteriohopanepolyols

scientific article published on 19 November 2019

Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis

scholarly article by Fumitaka Kudo et al published 17 September 2014 in Journal of the American Chemical Society

Characterization of polyphosphate glucokinase SCO5059 from Streptomyces coelicolor A3(2).

scientific article published on 7 November 2013

Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation

scientific article published in July 2010

Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256.

scientific article published on 24 November 2010

Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation.

scientific article published in August 2007

Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.

scientific article

Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster

article

Enzymatic preparation of neomycin C from ribostamycin.

scientific article published on 28 August 2009

Epimerization at C-3′′ in Butirosin Biosynthesis by an NAD+-Dependent Dehydrogenase BtrE and an NADPH-Dependent Reductase BtrF

scientific article published on 19 January 2015

Five-Membered Cyclitol Phosphate Formation by a myo-Inositol Phosphate Synthase Orthologue in the Biosynthesis of the Carbocyclic Nucleoside Antibiotic Aristeromycin.

scientific article published on 31 August 2016

Functional Characterization of 3-Aminobenzoic Acid Adenylation Enzyme PctU and UDP-N-Acetyl-d-Glucosamine: 3-Aminobenzoyl-ACP Glycosyltransferase PctL in Pactamycin Biosynthesis

scientific article published on 20 August 2019

Functional and Structural Analyses of the Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin

scientific article published on 18 November 2019

Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis

scientific article published on 02 April 2019

Generation of incednine derivatives by mutasynthesis

scientific article published on 04 June 2020

Genome Mining Reveals Two Novel Bacterial Sesquiterpene Cyclases: (−)-Germacradien-4-ol and (−)-epi-α-Bisabolol Synthases from Streptomyces citricolor

scientific article published on 01 October 2011

Genome Mining of the Hitachimycin Biosynthetic Gene Cluster: Involvement of a Phenylalanine-2,3-aminomutase in Biosynthesis

article

Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase ⬇️

article

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.

scientific article published on 13 June 2017

Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadura fulva subsp. indica ATCC 53714: substrate Specificity of the β-Amino Acid Selective Adenylating Enzyme FlvN.

scientific article

Identification of the incednine biosynthetic gene cluster: characterization of novel β-glutamate-β-decarboxylase IdnL3.

scientific article published on 7 August 2013

Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.

scientific article

Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin

scientific article

Mechanisms of β-amino acid incorporation in polyketide macrolactam biosynthesis.

scientific article published on 9 September 2016

NAD+ -Dependent Dehydrogenase PctP and Pyridoxal 5'-Phosphate Dependent Aminotransferase PctC Catalyze the First Postglycosylation Modification of the Sugar Intermediate in Pactamycin Biosynthesis

scientific article published on 17 November 2017

New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6.

scientific article published on 26 February 2009

Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis inStreptomyces graminofaciensA-8890

scientific article published on 08 January 2016

Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides

scientific article published in January 2002

Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

scientific article published on 01 November 2018

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

scientific article published on 21 May 2019

Role of glutamate 243 in the active site of 2-deoxy-scyllo-inosose synthase from Bacillus circulans

scientific article published on 10 October 2006

Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis.

scientific article

Stereochemistry in the Reaction of the myo-Inositol Phosphate Synthase Ortholog Ari2 during Aristeromycin Biosynthesis

scientific article published on 13 December 2019

Structural Analysis of the Glycine Oxidase Homologue CmiS2 Reveals a Unique Substrate Recognition Mechanism for Formation of a β-Amino Acid Starter Unit in Cremimycin Biosynthesis

scientific article published on 04 June 2019

Structural Basis of Protein–Protein Interactions between a trans-Acting Acyltransferase and Acyl Carrier Protein in Polyketide Disorazole Biosynthesis

scientific article published on 13 June 2018

Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products

Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.

scientific article published on February 2016

Substrate Recognition by a Dual-Function P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis.

scientific article published on 4 September 2017

Substrate Specificity of 2-Deoxy-scyllo-inosose Synthase, the Starter Enzyme for 2-Deoxystreptamine Biosynthesis, toward Deoxyglucose-6-phosphates and Proposed Mechanism

scientific article published on 01 December 1998

Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3'-deoxygenation of aminoglycoside antibiotics.

scientific article

Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells

scientific article published on 27 January 2016

The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism.

scientific article published on 22 September 2014

The crystal structure of the amidohydrolase VinJ shows a unique hydrophobic tunnel for its interaction with polyketide substrates

scientific article

The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.

scientific article published on 28 February 2012

Vicenistatin induces early endosome-derived vacuole formation in mammalian cells

scientific article published on February 2016

List of works by Fumitaka Kudo

A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics

A Unique Amino Transfer Mechanism for Constructing the β-Amino Fatty Acid Starter Unit in the Biosynthesis of the Macrolactam Antibiotic Cremimycin

A Unique Pathway for the 3-Aminobutyrate Starter Unit from l-Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine

A new family of glucose-1-phosphate/glucosamine-1-phosphate nucleotidylyltransferase in the biosynthetic pathways for antibiotics.

A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin.

Aminoglycoside Antibiotics: New Insights into the Biosynthetic Machinery of Old Drugs

An Engineered Aryl Acid Adenylation Domain with an Enlarged Substrate Binding Pocket

Biochemical and Structural Analysis of a Dehydrogenase, KanD2, and an Aminotransferase, KanS2, That Are Responsible for the Construction of the Kanosamine Moiety in Kanamycin Biosynthesis

Biochemical characterization and structural insight into aliphatic β-amino acid adenylation enzymes IdnL1 and CmiS6.

Biosynthesis of 2-deoxystreptamine-containing antibiotics in Streptoalloteichus hindustanus JCM 3268: characterization of 2-deoxy-scyllo-inosose synthase. ⬇️

Biosynthesis of natural products containing β-amino acids.

C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-adenosyl-l-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration

C-Methylation of S-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium

Carbon-free production of 2-deoxy-scyllo-inosose (DOI) in cyanobacterium Synechococcus elongatus PCC 7942.

Chapter 20 Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin

Characterization of Radical SAM Adenosylhopane Synthase, HpnH, which Catalyzes the 5'-Deoxyadenosyl Radical Addition to Diploptene in the Biosynthesis of C35 Bacteriohopanepolyols

Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis

Characterization of polyphosphate glucokinase SCO5059 from Streptomyces coelicolor A3(2).

Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation

Cloning of the biosynthetic gene cluster for naphthoxanthene antibiotic FD-594 from Streptomyces sp. TA-0256.

Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation.

Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics.

Enzymatic activity of a glycosyltransferase KanM2 encoded in the kanamycin biosynthetic gene cluster

Enzymatic preparation of neomycin C from ribostamycin.

Epimerization at C-3′′ in Butirosin Biosynthesis by an NAD+-Dependent Dehydrogenase BtrE and an NADPH-Dependent Reductase BtrF

Five-Membered Cyclitol Phosphate Formation by a myo-Inositol Phosphate Synthase Orthologue in the Biosynthesis of the Carbocyclic Nucleoside Antibiotic Aristeromycin.

Functional Characterization of 3-Aminobenzoic Acid Adenylation Enzyme PctU and UDP-N-Acetyl-d-Glucosamine: 3-Aminobenzoyl-ACP Glycosyltransferase PctL in Pactamycin Biosynthesis

Functional and Structural Analyses of the Split-Dehydratase Domain in the Biosynthesis of Macrolactam Polyketide Cremimycin

Functional and structural characterization of IdnL7, an adenylation enzyme involved in incednine biosynthesis

Generation of incednine derivatives by mutasynthesis

Genome Mining Reveals Two Novel Bacterial Sesquiterpene Cyclases: (−)-Germacradien-4-ol and (−)-epi-α-Bisabolol Synthases from Streptomyces citricolor

Genome Mining of the Hitachimycin Biosynthetic Gene Cluster: Involvement of a Phenylalanine-2,3-aminomutase in Biosynthesis

Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase ⬇️

Identification of a gene cluster for telomestatin biosynthesis and heterologous expression using a specific promoter in a clean host.

Identification of the Fluvirucin B2 (Sch 38518) Biosynthetic Gene Cluster from Actinomadura fulva subsp. indica ATCC 53714: substrate Specificity of the β-Amino Acid Selective Adenylating Enzyme FlvN.

Identification of the incednine biosynthetic gene cluster: characterization of novel β-glutamate-β-decarboxylase IdnL3.

Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis.

Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin

Mechanisms of β-amino acid incorporation in polyketide macrolactam biosynthesis.

NAD+ -Dependent Dehydrogenase PctP and Pyridoxal 5'-Phosphate Dependent Aminotransferase PctC Catalyze the First Postglycosylation Modification of the Sugar Intermediate in Pactamycin Biosynthesis

New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6.

Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis inStreptomyces graminofaciensA-8890

Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides

Protein–protein interactions in polyketide synthase–nonribosomal peptide synthetase hybrid assembly lines

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

Role of glutamate 243 in the active site of 2-deoxy-scyllo-inosose synthase from Bacillus circulans

Stereochemical recognition of doubly functional aminotransferase in 2-deoxystreptamine biosynthesis.

Stereochemistry in the Reaction of the myo-Inositol Phosphate Synthase Ortholog Ari2 during Aristeromycin Biosynthesis

Structural Analysis of the Glycine Oxidase Homologue CmiS2 Reveals a Unique Substrate Recognition Mechanism for Formation of a β-Amino Acid Starter Unit in Cremimycin Biosynthesis

Structural Basis of Protein–Protein Interactions between a trans-Acting Acyltransferase and Acyl Carrier Protein in Polyketide Disorazole Biosynthesis

Structural basis of the nonribosomal codes for nonproteinogenic amino acid selective adenylation enzymes in the biosynthesis of natural products

Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.

Substrate Recognition by a Dual-Function P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis.

Substrate Specificity of 2-Deoxy-scyllo-inosose Synthase, the Starter Enzyme for 2-Deoxystreptamine Biosynthesis, toward Deoxyglucose-6-phosphates and Proposed Mechanism

Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3'-deoxygenation of aminoglycoside antibiotics.

Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells

The crystal structure of the adenylation enzyme VinN reveals a unique β-amino acid recognition mechanism.

The crystal structure of the amidohydrolase VinJ shows a unique hydrophobic tunnel for its interaction with polyketide substrates

The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the α-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.

Vicenistatin induces early endosome-derived vacuole formation in mammalian cells